Matches in SemOpenAlex for { <https://semopenalex.org/work/W4223584929> ?p ?o ?g. }
- W4223584929 endingPage "778" @default.
- W4223584929 startingPage "769" @default.
- W4223584929 abstract "Pulmonary nodules (PNs) are documented in up to 30% of computed tomography (CT) reports. PNs of indeterminate nature (IPN) have been reported to be associated with increased psychological distress and deterioration of the quality of life. Despite lack of solid evidence, severe anxiety or depression has been proposed to be one of the surgical indications in expert consensus for IPN management. So far, there is no established criterion to guide the decision-making process, or to ensure evidence-based management. This study aims to evaluate whether psychological distress could be a surgical indication for IPN, and to establish an evidence-based distress threshold for necessary surgical intervention.This prospective observational study in real-world setting will involve an expected sample size of 1,253 IPN patients from the thoracic clinic of Guangdong Provincial People's Hospital. Web-based questionnaires powered by Wen Juan Xing (WJX) platform will be delivered to the patients for baseline data collection and psychological screening. Based on our pilot study, a total of 376 IPN patients with abnormal or borderline abnormal psychological states, as assessed by the Hospital Anxiety and Depression Scale (HADS), will be followed for 1 year before proceeding to the final analysis. The planned study period is from Jan 1, 2021, to Sept 30, 2022, and will entail two HADS assessments at baseline and follow-up. Sleep quality and indicators of healthcare-seeking behavior, such as the number of unplanned clinic visits or CT scans per year, will be used as anchors of psychological state. Patients who undergo surgical resection against the follow-up plan will be enrolled into a surgical group (expected n=94), while those who adhere to their plan will be automatically classified as a follow-up group after 1-year follow-up (expected n=282). Statistical measures such as independent-samples t-test and receiver operating characteristics (ROC) analysis will be used to assess the difference in psychological changes between the groups, and to generate an optimal threshold alerting surgical need. A Chi-square test or nonparametric test will be used to compare the baseline characteristics. Contributors to psychological burden and their effect sizes will be evaluated using general linear regression.To date, data on the psychological benefits of surgical resection of IPN remains scanty. Evidence-based procedure of patient selection using appropriate psychological screening tools is crucial in improving the quality of care and preventing overtreatment. This protocol describes the rationale and methodology to address this unmet clinical need using real-world data, aiming to bridge the gap between clinical guidelines and real-world practice.ClinicalTrials.gov Identifier: NCT04857333. Registered April 23, 2021." @default.
- W4223584929 created "2022-04-15" @default.
- W4223584929 creator A5000048962 @default.
- W4223584929 creator A5000473685 @default.
- W4223584929 creator A5005425760 @default.
- W4223584929 creator A5012513899 @default.
- W4223584929 creator A5023873266 @default.
- W4223584929 creator A5035174542 @default.
- W4223584929 creator A5042317139 @default.
- W4223584929 creator A5047755795 @default.
- W4223584929 creator A5048669025 @default.
- W4223584929 creator A5049649457 @default.
- W4223584929 creator A5063874612 @default.
- W4223584929 creator A5066741300 @default.
- W4223584929 creator A5070237275 @default.
- W4223584929 creator A5075152106 @default.
- W4223584929 creator A5085824200 @default.
- W4223584929 creator A5086878702 @default.
- W4223584929 creator A5090911840 @default.
- W4223584929 date "2022-03-01" @default.
- W4223584929 modified "2023-10-10" @default.
- W4223584929 title "Should psychological distress be listed as a surgical indication for indeterminate pulmonary nodules: protocol for a prospective cohort study in real-world settings" @default.
- W4223584929 cites W1982212980 @default.
- W4223584929 cites W1987732343 @default.
- W4223584929 cites W2054108549 @default.
- W4223584929 cites W2054231342 @default.
- W4223584929 cites W2085704954 @default.
- W4223584929 cites W2091376304 @default.
- W4223584929 cites W2100533308 @default.
- W4223584929 cites W2112520440 @default.
- W4223584929 cites W2121203541 @default.
- W4223584929 cites W2129598353 @default.
- W4223584929 cites W2143039053 @default.
- W4223584929 cites W2164472128 @default.
- W4223584929 cites W2331458320 @default.
- W4223584929 cites W2506990800 @default.
- W4223584929 cites W2507995480 @default.
- W4223584929 cites W2516664799 @default.
- W4223584929 cites W2521374415 @default.
- W4223584929 cites W2594318146 @default.
- W4223584929 cites W2792857977 @default.
- W4223584929 cites W2800262248 @default.
- W4223584929 cites W2995137269 @default.
- W4223584929 cites W3094117229 @default.
- W4223584929 cites W3153216719 @default.
- W4223584929 cites W3172431965 @default.
- W4223584929 doi "https://doi.org/10.21037/jtd-21-1423" @default.
- W4223584929 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35399240" @default.
- W4223584929 hasPublicationYear "2022" @default.
- W4223584929 type Work @default.
- W4223584929 citedByCount "2" @default.
- W4223584929 countsByYear W42235849292022 @default.
- W4223584929 countsByYear W42235849292023 @default.
- W4223584929 crossrefType "journal-article" @default.
- W4223584929 hasAuthorship W4223584929A5000048962 @default.
- W4223584929 hasAuthorship W4223584929A5000473685 @default.
- W4223584929 hasAuthorship W4223584929A5005425760 @default.
- W4223584929 hasAuthorship W4223584929A5012513899 @default.
- W4223584929 hasAuthorship W4223584929A5023873266 @default.
- W4223584929 hasAuthorship W4223584929A5035174542 @default.
- W4223584929 hasAuthorship W4223584929A5042317139 @default.
- W4223584929 hasAuthorship W4223584929A5047755795 @default.
- W4223584929 hasAuthorship W4223584929A5048669025 @default.
- W4223584929 hasAuthorship W4223584929A5049649457 @default.
- W4223584929 hasAuthorship W4223584929A5063874612 @default.
- W4223584929 hasAuthorship W4223584929A5066741300 @default.
- W4223584929 hasAuthorship W4223584929A5070237275 @default.
- W4223584929 hasAuthorship W4223584929A5075152106 @default.
- W4223584929 hasAuthorship W4223584929A5085824200 @default.
- W4223584929 hasAuthorship W4223584929A5086878702 @default.
- W4223584929 hasAuthorship W4223584929A5090911840 @default.
- W4223584929 hasBestOaLocation W42235849291 @default.
- W4223584929 hasConcept C118552586 @default.
- W4223584929 hasConcept C126322002 @default.
- W4223584929 hasConcept C139265228 @default.
- W4223584929 hasConcept C139719470 @default.
- W4223584929 hasConcept C141071460 @default.
- W4223584929 hasConcept C142724271 @default.
- W4223584929 hasConcept C159110408 @default.
- W4223584929 hasConcept C162324750 @default.
- W4223584929 hasConcept C1862650 @default.
- W4223584929 hasConcept C188816634 @default.
- W4223584929 hasConcept C194828623 @default.
- W4223584929 hasConcept C204787440 @default.
- W4223584929 hasConcept C23131810 @default.
- W4223584929 hasConcept C27415008 @default.
- W4223584929 hasConcept C2776867660 @default.
- W4223584929 hasConcept C2778739829 @default.
- W4223584929 hasConcept C2779951463 @default.
- W4223584929 hasConcept C2780385302 @default.
- W4223584929 hasConcept C2780665704 @default.
- W4223584929 hasConcept C3020031316 @default.
- W4223584929 hasConcept C558461103 @default.
- W4223584929 hasConcept C70410870 @default.
- W4223584929 hasConcept C71924100 @default.
- W4223584929 hasConcept C72563966 @default.
- W4223584929 hasConceptScore W4223584929C118552586 @default.
- W4223584929 hasConceptScore W4223584929C126322002 @default.