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• W4223586146 endingPage "9276" @default.
• W4223586146 startingPage "9263" @default.
• W4223586146 abstract "It has been shown previously in protonated, deprotonated and ionized guanine-cytosine base pairs that intra-base pair proton transfer from the N1-H at the Watson-Crick edge of guanine to the complementary nucleobase prompts non-statistical dissociation of the base-pair system, and the dissociation of a proton-transferred base-pair structure is kinetically more favored than that of the starting, conventional base-pair structure. However, the fundamental chemistry underlying this anomalous and intriguing kinetics has not been completely revealed, which warrants the examination of more base-pair systems in different structural contexts in order to derive a generalized base-pair structure-kinetics correlation. The purpose of the present work is to expand the investigation to the non-canonical homodimeric and heterodimeric radical cations of 9-methylguanine (9MG) and 9-methyl-8-oxoguanine (9MOG), i.e., [9MG·9MG]˙+, [9MOG·9MG]˙+ and [9MOG·9MOG]˙+. Experimentally, collision-induced dissociation tandem mass spectrometry coupled with an electrospray ionization (ESI) source was used for the formation of base-pair radical cations, followed by detection of dissociation product ions and cross sections in the collisions with Xe gas under single ion-molecule collision conditions and as a function of the center-of-mass collision energy. Computationally, density functional theory and coupled cluster theory were used to calculate and identify probable base-pair structures and intra-base pair proton transfer and hydrogen transfer reactions, followed by kinetics modeling to explore the properties of dissociation transition states and kinetic factors. The significance of this work is twofold: it provides insight into base-pair opening kinetics in three biologically-important, non-canonical systems upon oxidative and ionization damage; and it links non-statistical dissociation to intra-base pair proton-transfer originating from the N1-H at the Watson-Crick edge of 8-oxoguanine, enhancing understanding towards the base-pair fragmentation assisted by proton transfer." @default.
• W4223586146 created "2022-04-15" @default.
• W4223586146 creator A5053680628 @default.
• W4223586146 creator A5060054293 @default.
• W4223586146 creator A5085326525 @default.
• W4223586146 date "2022-01-01" @default.
• W4223586146 modified "2023-10-09" @default.
• W4223586146 title "Collision-induced dissociation of homodimeric and heterodimeric radical cations of 9-methylguanine and 9-methyl-8-oxoguanine: correlation between intra-base pair proton transfer originating from the N1–H at a Watson–Crick edge and non-statistical dissociation" @default.
• W4223586146 cites W1425326304 @default.
• W4223586146 cites W1489882701 @default.
• W4223586146 cites W1556072913 @default.
• W4223586146 cites W1568298646 @default.
• W4223586146 cites W1765683821 @default.
• W4223586146 cites W1861159163 @default.
• W4223586146 cites W1967482965 @default.
• W4223586146 cites W1967493502 @default.
• W4223586146 cites W1967664531 @default.
• W4223586146 cites W1971339396 @default.
• W4223586146 cites W1973957656 @default.
• W4223586146 cites W1976774792 @default.
• W4223586146 cites W1979137822 @default.
• W4223586146 cites W1983673827 @default.
• W4223586146 cites W1984181406 @default.
• W4223586146 cites W1984736034 @default.
• W4223586146 cites W1985543045 @default.
• W4223586146 cites W1986216535 @default.
• W4223586146 cites W1991370075 @default.
• W4223586146 cites W1991662337 @default.
• W4223586146 cites W1993091782 @default.
• W4223586146 cites W1993130797 @default.
• W4223586146 cites W1996877293 @default.
• W4223586146 cites W1998127752 @default.
• W4223586146 cites W1999997192 @default.
• W4223586146 cites W2001908539 @default.
• W4223586146 cites W2002874596 @default.
• W4223586146 cites W2004138506 @default.
• W4223586146 cites W2004791384 @default.
• W4223586146 cites W2005298772 @default.
• W4223586146 cites W2007059960 @default.
• W4223586146 cites W2008086050 @default.
• W4223586146 cites W2008480228 @default.
• W4223586146 cites W2008901532 @default.
• W4223586146 cites W2012694883 @default.
• W4223586146 cites W2014168546 @default.
• W4223586146 cites W2014639126 @default.
• W4223586146 cites W2017062823 @default.
• W4223586146 cites W2017120569 @default.
• W4223586146 cites W2021094219 @default.
• W4223586146 cites W2021920164 @default.
• W4223586146 cites W2022889126 @default.
• W4223586146 cites W2026533605 @default.
• W4223586146 cites W2031167250 @default.
• W4223586146 cites W2033248502 @default.
• W4223586146 cites W2035179065 @default.
• W4223586146 cites W2036358440 @default.
• W4223586146 cites W2037647371 @default.
• W4223586146 cites W2037647914 @default.
• W4223586146 cites W2039127202 @default.
• W4223586146 cites W2040843368 @default.
• W4223586146 cites W2043578603 @default.
• W4223586146 cites W2045727840 @default.
• W4223586146 cites W2048847153 @default.
• W4223586146 cites W2050423762 @default.
• W4223586146 cites W2051531745 @default.
• W4223586146 cites W2053223828 @default.
• W4223586146 cites W2055689696 @default.
• W4223586146 cites W2061078869 @default.
• W4223586146 cites W2062147011 @default.
• W4223586146 cites W2063646620 @default.
• W4223586146 cites W2064863303 @default.
• W4223586146 cites W2064916912 @default.
• W4223586146 cites W2066889162 @default.
• W4223586146 cites W2067278836 @default.
• W4223586146 cites W2071884305 @default.
• W4223586146 cites W2077193663 @default.
• W4223586146 cites W2077450957 @default.
• W4223586146 cites W2078014028 @default.
• W4223586146 cites W2078356260 @default.
• W4223586146 cites W2078748820 @default.
• W4223586146 cites W2078803436 @default.
• W4223586146 cites W2078843151 @default.
• W4223586146 cites W2081562442 @default.
• W4223586146 cites W2084315600 @default.
• W4223586146 cites W2085134918 @default.
• W4223586146 cites W2085953571 @default.
• W4223586146 cites W2087099549 @default.
• W4223586146 cites W2087187906 @default.
• W4223586146 cites W2089759714 @default.
• W4223586146 cites W2090685881 @default.
• W4223586146 cites W2091337681 @default.
• W4223586146 cites W2092930273 @default.
• W4223586146 cites W2094980984 @default.
• W4223586146 cites W2106096530 @default.
• W4223586146 cites W2112850441 @default.
• W4223586146 cites W2122160010 @default.
• W4223586146 cites W2123657895 @default.
• W4223586146 cites W2126466006 @default.
• W4223586146 cites W2129181638 @default.

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