FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4223587133> ?p ?o ?g. }

• W4223587133 abstract "Abstract Background Social impairments are core features of multiple neurodevelopmental disorders. Previous neuroimaging studies have focused on elucidating associations between brain function and social impairments within disorders but have not predicted these impairments from brain connectivity in a transdiagnostic manner, across several diagnostic categories. This study used a machine learning approach to examine functional connectivity that predicts elevated social impairments in a transdiagnostic sample of youths. We hypothesized that predictive edges would be from brain regions involved in social cognition. Methods Connectome-based predictive modeling (CPM) was used to build a transdiagnostic model of social impairments as measured by the Social Responsiveness Scale (SRS-2, raw score >75). We used functional connectivity data during a social movie-watching task from the Healthy Brain Network data (N=144, mean age=11.68 (3.52), 32% male). The average number of diagnoses was 3.4 (SD = 1.82, range = 0–11), including ASD (40.9%), ADHD (79%), mood disorders (15.9%), and anxiety disorders (43%). A similar transdiagnostic sample high SRS-2 scores (n=41) was used for replication. Result SRS-2 scores were predicted from functional connectivity data using both 10-fold cross-validation (median q 2 =0.32, r =0.57, p <.001) and leave-one-group-out cross-validation (median q 2 ’s >0.04, r’s >0.36, p’s <.001). Predictive connections were widely distributed across the brain but were rooted in regions involved in social cognition, the subcortex, and the salience network. The model successfully predicted SRS-2 scores in the replication sample ( r= 0.33, p <.035, df =39). Conclusion We identified connectivity patterns predictive of social impairments in a transdiagnostic sample. These networks have the potential to provide insight into development novel targeted interventions for social impairments across traditional diagnostic categories." @default.
• W4223587133 created "2022-04-15" @default.
• W4223587133 creator A5020064980 @default.
• W4223587133 creator A5028606627 @default.
• W4223587133 creator A5044673394 @default.
• W4223587133 creator A5055510275 @default.
• W4223587133 creator A5069233580 @default.
• W4223587133 creator A5072534297 @default.
• W4223587133 creator A5086037619 @default.
• W4223587133 date "2022-04-12" @default.
• W4223587133 modified "2023-09-26" @default.
• W4223587133 title "Predicting Transdiagnostic Social Impairments in Childhood using Connectome-based Predictive Modeling" @default.
• W4223587133 cites W1486726446 @default.
• W4223587133 cites W1973140577 @default.
• W4223587133 cites W1977465442 @default.
• W4223587133 cites W2009631611 @default.
• W4223587133 cites W2018667648 @default.
• W4223587133 cites W2053231114 @default.
• W4223587133 cites W2116442163 @default.
• W4223587133 cites W2118796430 @default.
• W4223587133 cites W2128595931 @default.
• W4223587133 cites W2131009185 @default.
• W4223587133 cites W2133247969 @default.
• W4223587133 cites W2148396375 @default.
• W4223587133 cites W2148605740 @default.
• W4223587133 cites W2154201160 @default.
• W4223587133 cites W2155698011 @default.
• W4223587133 cites W2158063953 @default.
• W4223587133 cites W2180389740 @default.
• W4223587133 cites W2206641237 @default.
• W4223587133 cites W2301452501 @default.
• W4223587133 cites W2568162413 @default.
• W4223587133 cites W2587272693 @default.
• W4223587133 cites W2738943346 @default.
• W4223587133 cites W2792637345 @default.
• W4223587133 cites W2801938373 @default.
• W4223587133 cites W2811487837 @default.
• W4223587133 cites W2902466381 @default.
• W4223587133 cites W2921949803 @default.
• W4223587133 cites W2926911984 @default.
• W4223587133 cites W2945728732 @default.
• W4223587133 cites W2965306458 @default.
• W4223587133 cites W2966020520 @default.
• W4223587133 cites W2989872196 @default.
• W4223587133 cites W3004537750 @default.
• W4223587133 cites W3009343398 @default.
• W4223587133 cites W3011943352 @default.
• W4223587133 cites W3045001646 @default.
• W4223587133 cites W3062208440 @default.
• W4223587133 cites W3151549332 @default.
• W4223587133 cites W4250982419 @default.
• W4223587133 doi "https://doi.org/10.1101/2022.04.07.22273518" @default.
• W4223587133 hasPublicationYear "2022" @default.
• W4223587133 type Work @default.
• W4223587133 citedByCount "2" @default.
• W4223587133 countsByYear W42235871332022 @default.
• W4223587133 crossrefType "posted-content" @default.
• W4223587133 hasAuthorship W4223587133A5020064980 @default.
• W4223587133 hasAuthorship W4223587133A5028606627 @default.
• W4223587133 hasAuthorship W4223587133A5044673394 @default.
• W4223587133 hasAuthorship W4223587133A5055510275 @default.
• W4223587133 hasAuthorship W4223587133A5069233580 @default.
• W4223587133 hasAuthorship W4223587133A5072534297 @default.
• W4223587133 hasAuthorship W4223587133A5086037619 @default.
• W4223587133 hasBestOaLocation W42235871331 @default.
• W4223587133 hasConcept C118552586 @default.
• W4223587133 hasConcept C138496976 @default.
• W4223587133 hasConcept C15744967 @default.
• W4223587133 hasConcept C169760540 @default.
• W4223587133 hasConcept C169900460 @default.
• W4223587133 hasConcept C2777545354 @default.
• W4223587133 hasConcept C2780733359 @default.
• W4223587133 hasConcept C3018011982 @default.
• W4223587133 hasConcept C45715564 @default.
• W4223587133 hasConcept C558461103 @default.
• W4223587133 hasConcept C58693492 @default.
• W4223587133 hasConcept C70410870 @default.
• W4223587133 hasConcept C97820695 @default.
• W4223587133 hasConceptScore W4223587133C118552586 @default.
• W4223587133 hasConceptScore W4223587133C138496976 @default.
• W4223587133 hasConceptScore W4223587133C15744967 @default.
• W4223587133 hasConceptScore W4223587133C169760540 @default.
• W4223587133 hasConceptScore W4223587133C169900460 @default.
• W4223587133 hasConceptScore W4223587133C2777545354 @default.
• W4223587133 hasConceptScore W4223587133C2780733359 @default.
• W4223587133 hasConceptScore W4223587133C3018011982 @default.
• W4223587133 hasConceptScore W4223587133C45715564 @default.
• W4223587133 hasConceptScore W4223587133C558461103 @default.
• W4223587133 hasConceptScore W4223587133C58693492 @default.
• W4223587133 hasConceptScore W4223587133C70410870 @default.
• W4223587133 hasConceptScore W4223587133C97820695 @default.
• W4223587133 hasLocation W42235871331 @default.
• W4223587133 hasOpenAccess W4223587133 @default.
• W4223587133 hasPrimaryLocation W42235871331 @default.
• W4223587133 hasRelatedWork W2008607322 @default.
• W4223587133 hasRelatedWork W2507387536 @default.
• W4223587133 hasRelatedWork W2597400155 @default.
• W4223587133 hasRelatedWork W2734603135 @default.
• W4223587133 hasRelatedWork W2797497970 @default.
• W4223587133 hasRelatedWork W2952871955 @default.

• next