FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4223588478> ?p ?o ?g. }

• W4223588478 endingPage "3807" @default.
• W4223588478 startingPage "3798" @default.
• W4223588478 abstract "The co-delivery of multiple drugs using one drug carrier is a viable strategy to optimize drug dosage and reduce the side effects in chemotherapy. Herein, a hydrophilic animal protein (silk fibroin) and a hydrophobic plant protein (zein) were selected for preparing a composite drug carrier. Adapting our previously developed method for the preparation of regenerated silk fibroin (RSF) nanospheres, we prepared RSF/zein nanospheres that displayed an interesting structure including a single central hole. The particle size of the RSF/zein nanospheres was regulated from 150 to 460 nm by varying the preparation conditions, implying that such a drug carrier is suitable for both intravenous administration and lymphatic chemotherapy. Two anti-cancer drugs with different target sites, paclitaxel (PTX) and curcumin (CUR), were selected for the preparation of dual-drug-loaded CUR/PTX@RSF/zein nanospheres. Both drugs achieved a high loading capacity in the RSF/zein nanospheres, i.e., 8.2% for PTX and 12.1% for CUR. Subsequently, the encapsulated PTX and CUR were released from the RSF/zein nanospheres in a sustained manner for at least 7 days. Importantly, these dual-drug-loaded RSF/zein nanospheres exhibited a considerable synergistic therapeutic effect, showing more efficient suppression of in vitro cancer cell growth than free PTX or CUR, a combination of free PTX and CUR, or single-drug-loaded nanospheres. Therefore, the CUR/PTX@RSF/zein nanospheres developed in this study hold great potential for combination chemotherapy in future clinical applications." @default.
• W4223588478 created "2022-04-15" @default.
• W4223588478 creator A5021481144 @default.
• W4223588478 creator A5059720145 @default.
• W4223588478 creator A5063988555 @default.
• W4223588478 creator A5076512663 @default.
• W4223588478 creator A5076547809 @default.
• W4223588478 creator A5078763413 @default.
• W4223588478 date "2022-01-01" @default.
• W4223588478 modified "2023-09-26" @default.
• W4223588478 title "Animal protein-plant protein composite nanospheres for dual-drug loading and synergistic cancer therapy" @default.
• W4223588478 cites W1831251608 @default.
• W4223588478 cites W1968212891 @default.
• W4223588478 cites W1970470336 @default.
• W4223588478 cites W1973486900 @default.
• W4223588478 cites W1981599964 @default.
• W4223588478 cites W1989195046 @default.
• W4223588478 cites W1990703828 @default.
• W4223588478 cites W2001067434 @default.
• W4223588478 cites W2012867962 @default.
• W4223588478 cites W2021876818 @default.
• W4223588478 cites W2031968219 @default.
• W4223588478 cites W2032760352 @default.
• W4223588478 cites W2052116137 @default.
• W4223588478 cites W2062029885 @default.
• W4223588478 cites W2064674946 @default.
• W4223588478 cites W2072997205 @default.
• W4223588478 cites W2082262145 @default.
• W4223588478 cites W2082511916 @default.
• W4223588478 cites W2103892358 @default.
• W4223588478 cites W2148324547 @default.
• W4223588478 cites W2161015285 @default.
• W4223588478 cites W2164920060 @default.
• W4223588478 cites W2195943854 @default.
• W4223588478 cites W2296389641 @default.
• W4223588478 cites W2339271230 @default.
• W4223588478 cites W2470233012 @default.
• W4223588478 cites W2531916724 @default.
• W4223588478 cites W2547186658 @default.
• W4223588478 cites W2554094598 @default.
• W4223588478 cites W2561853431 @default.
• W4223588478 cites W2598259506 @default.
• W4223588478 cites W2605434989 @default.
• W4223588478 cites W2615993918 @default.
• W4223588478 cites W2738054243 @default.
• W4223588478 cites W2741349883 @default.
• W4223588478 cites W2748359040 @default.
• W4223588478 cites W2752543711 @default.
• W4223588478 cites W2785037592 @default.
• W4223588478 cites W2790163415 @default.
• W4223588478 cites W2794954838 @default.
• W4223588478 cites W2807410315 @default.
• W4223588478 cites W2889814971 @default.
• W4223588478 cites W2902209340 @default.
• W4223588478 cites W2920648489 @default.
• W4223588478 cites W2944726119 @default.
• W4223588478 cites W2951099089 @default.
• W4223588478 cites W3014625972 @default.
• W4223588478 cites W3093134820 @default.
• W4223588478 doi "https://doi.org/10.1039/d2tb00368f" @default.
• W4223588478 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35416829" @default.
• W4223588478 hasPublicationYear "2022" @default.
• W4223588478 type Work @default.
• W4223588478 citedByCount "10" @default.
• W4223588478 countsByYear W42235884782022 @default.
• W4223588478 countsByYear W42235884782023 @default.
• W4223588478 crossrefType "journal-article" @default.
• W4223588478 hasAuthorship W4223588478A5021481144 @default.
• W4223588478 hasAuthorship W4223588478A5059720145 @default.
• W4223588478 hasAuthorship W4223588478A5063988555 @default.
• W4223588478 hasAuthorship W4223588478A5076512663 @default.
• W4223588478 hasAuthorship W4223588478A5076547809 @default.
• W4223588478 hasAuthorship W4223588478A5078763413 @default.
• W4223588478 hasConcept C104779481 @default.
• W4223588478 hasConcept C122302759 @default.
• W4223588478 hasConcept C12554922 @default.
• W4223588478 hasConcept C13245373 @default.
• W4223588478 hasConcept C141071460 @default.
• W4223588478 hasConcept C159985019 @default.
• W4223588478 hasConcept C171250308 @default.
• W4223588478 hasConcept C192562407 @default.
• W4223588478 hasConcept C2776694085 @default.
• W4223588478 hasConcept C2777292972 @default.
• W4223588478 hasConcept C2778250585 @default.
• W4223588478 hasConcept C2779820397 @default.
• W4223588478 hasConcept C2780035454 @default.
• W4223588478 hasConcept C2780431358 @default.
• W4223588478 hasConcept C71924100 @default.
• W4223588478 hasConcept C86803240 @default.
• W4223588478 hasConcept C98274493 @default.
• W4223588478 hasConceptScore W4223588478C104779481 @default.
• W4223588478 hasConceptScore W4223588478C122302759 @default.
• W4223588478 hasConceptScore W4223588478C12554922 @default.
• W4223588478 hasConceptScore W4223588478C13245373 @default.
• W4223588478 hasConceptScore W4223588478C141071460 @default.
• W4223588478 hasConceptScore W4223588478C159985019 @default.
• W4223588478 hasConceptScore W4223588478C171250308 @default.
• W4223588478 hasConceptScore W4223588478C192562407 @default.

• next