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- W4223607106 abstract "Tumor-associated macrophages (TAMs) are a major cellular component in the tumor microenvironment (TME). However, the relationship between the phenotype and metabolic pattern of TAMs remains poorly understood. We performed single-cell transcriptome profiling on hepatic TAMs from mice bearing liver metastatic tumors. We find that TAMs manifest high heterogeneity at the levels of transcription, development, metabolism, and function. Integrative analyses and validation experiments indicate that increased purine metabolism is a feature of TAMs with pro-tumor and terminal differentiation phenotypes. Like mouse TAMs, human TAMs are highly heterogeneous. Human TAMs with increased purine metabolism exhibit a pro-tumor phenotype and correlate with poor therapeutic efficacy to immune checkpoint blockade. Altogether, our work demonstrates that TAMs are developmentally, metabolically, and functionally heterogeneous and purine metabolism may be a key metabolic feature of a pro-tumor macrophage population." @default.
- W4223607106 created "2022-04-15" @default.
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- W4223607106 date "2022-04-01" @default.
- W4223607106 modified "2023-10-18" @default.
- W4223607106 title "Metabolism drives macrophage heterogeneity in the tumor microenvironment" @default.
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- W4223607106 cites W2058648826 @default.
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- W4223607106 cites W2070855360 @default.
- W4223607106 cites W2072462631 @default.
- W4223607106 cites W2076743146 @default.
- W4223607106 cites W2095485692 @default.
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- W4223607106 cites W2110256992 @default.
- W4223607106 cites W2112940058 @default.
- W4223607106 cites W2123105952 @default.
- W4223607106 cites W2130410032 @default.
- W4223607106 cites W2135703618 @default.
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- W4223607106 cites W2806265592 @default.
- W4223607106 cites W2810097927 @default.
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- W4223607106 cites W2932965638 @default.
- W4223607106 cites W2943726497 @default.
- W4223607106 cites W2950372712 @default.
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- W4223607106 cites W2952990620 @default.
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- W4223607106 cites W2966465234 @default.
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- W4223607106 cites W2988464219 @default.
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- W4223607106 doi "https://doi.org/10.1016/j.celrep.2022.110609" @default.
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