Matches in SemOpenAlex for { <https://semopenalex.org/work/W4223614665> ?p ?o ?g. }
- W4223614665 abstract "Cochlea macrophages regulate cochlea inflammation and may harbors the potentials to protect hearing function from injury, including acoustic overstimulation. Cochlea macrophage numbers increase at 3-7 days after acoustic stimulation. However, the exact timing of macrophage infiltration and maturation from inflammatory monocytes is unclear. Furthermore, neutrophils may also be involved in this process. Therefore, in this study, we investigated time-dependent immune cell infiltration, macrophage transformation, and neutrophil involvement following acoustic stimulation. Flow cytometry and immunofluorescence were conducted in C-X3-C motif chemokine receptor 1 (CX3CR1)+/GFP mice after acoustic overstimulation (at baseline and at 1, 2, 3, and 5 days after exposure to 120 dB for 1 h) to identify inflammatory monocytes in the cochlea. RNA-sequencing and quantitative polymerase chain reaction were performed to identify differentially expressed genes. Inflammatory monocytes infiltrated into the lower portion of the lateral wall within 2 days after acoustic overstimulation (dpn), followed by transformation into macrophages at 3-5 dpn via CX3CR1 upregulation and Ly6C downregulation. In addition, inflammatory monocytes were aggregated inside the collecting venule only at 1 dpn. Neutrophils were not a major type of phagocyte during this response. The gene encoding C-C motif chemokine ligand 2 gene was significantly upregulated as early as 3 h after acoustic overstimulation. Given these results, treatment to control immune response after a noise-induced hearing loss should be applied as soon as possible." @default.
- W4223614665 created "2022-04-15" @default.
- W4223614665 creator A5007208270 @default.
- W4223614665 creator A5007871609 @default.
- W4223614665 creator A5011007448 @default.
- W4223614665 creator A5031519656 @default.
- W4223614665 creator A5067696930 @default.
- W4223614665 creator A5086373555 @default.
- W4223614665 date "2022-04-12" @default.
- W4223614665 modified "2023-09-25" @default.
- W4223614665 title "The Time Course of Monocytes Infiltration After Acoustic Overstimulation" @default.
- W4223614665 cites W1486677432 @default.
- W4223614665 cites W1602437032 @default.
- W4223614665 cites W1976549834 @default.
- W4223614665 cites W1984115097 @default.
- W4223614665 cites W1990687389 @default.
- W4223614665 cites W1993677761 @default.
- W4223614665 cites W1993979020 @default.
- W4223614665 cites W2005154068 @default.
- W4223614665 cites W2009884378 @default.
- W4223614665 cites W2014173361 @default.
- W4223614665 cites W2022443457 @default.
- W4223614665 cites W2026578487 @default.
- W4223614665 cites W2048579894 @default.
- W4223614665 cites W2053943239 @default.
- W4223614665 cites W2067829514 @default.
- W4223614665 cites W2071340776 @default.
- W4223614665 cites W2075264981 @default.
- W4223614665 cites W2078291178 @default.
- W4223614665 cites W2081374651 @default.
- W4223614665 cites W2115825738 @default.
- W4223614665 cites W2132864045 @default.
- W4223614665 cites W2141512146 @default.
- W4223614665 cites W2161991472 @default.
- W4223614665 cites W2174476282 @default.
- W4223614665 cites W2344245973 @default.
- W4223614665 cites W2555639984 @default.
- W4223614665 cites W2564979550 @default.
- W4223614665 cites W2567233995 @default.
- W4223614665 cites W2606650217 @default.
- W4223614665 cites W2609733407 @default.
- W4223614665 cites W2773092691 @default.
- W4223614665 cites W2781241074 @default.
- W4223614665 cites W2862412211 @default.
- W4223614665 cites W2949892392 @default.
- W4223614665 cites W2989683066 @default.
- W4223614665 cites W2999187295 @default.
- W4223614665 cites W3024931479 @default.
- W4223614665 cites W3025099282 @default.
- W4223614665 cites W3033697948 @default.
- W4223614665 cites W3034008931 @default.
- W4223614665 cites W3044650920 @default.
- W4223614665 cites W3087290246 @default.
- W4223614665 cites W3120349897 @default.
- W4223614665 cites W3199123727 @default.
- W4223614665 cites W3205055874 @default.
- W4223614665 cites W3210246157 @default.
- W4223614665 cites W619479224 @default.
- W4223614665 doi "https://doi.org/10.3389/fncel.2022.844480" @default.
- W4223614665 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35496904" @default.
- W4223614665 hasPublicationYear "2022" @default.
- W4223614665 type Work @default.
- W4223614665 citedByCount "4" @default.
- W4223614665 countsByYear W42236146652022 @default.
- W4223614665 countsByYear W42236146652023 @default.
- W4223614665 crossrefType "journal-article" @default.
- W4223614665 hasAuthorship W4223614665A5007208270 @default.
- W4223614665 hasAuthorship W4223614665A5007871609 @default.
- W4223614665 hasAuthorship W4223614665A5011007448 @default.
- W4223614665 hasAuthorship W4223614665A5031519656 @default.
- W4223614665 hasAuthorship W4223614665A5067696930 @default.
- W4223614665 hasAuthorship W4223614665A5086373555 @default.
- W4223614665 hasBestOaLocation W42236146651 @default.
- W4223614665 hasConcept C104317684 @default.
- W4223614665 hasConcept C127561419 @default.
- W4223614665 hasConcept C12823836 @default.
- W4223614665 hasConcept C13373296 @default.
- W4223614665 hasConcept C134018914 @default.
- W4223614665 hasConcept C164027704 @default.
- W4223614665 hasConcept C169760540 @default.
- W4223614665 hasConcept C185592680 @default.
- W4223614665 hasConcept C203014093 @default.
- W4223614665 hasConcept C24998067 @default.
- W4223614665 hasConcept C2776914184 @default.
- W4223614665 hasConcept C2779356876 @default.
- W4223614665 hasConcept C2780130748 @default.
- W4223614665 hasConcept C2780493683 @default.
- W4223614665 hasConcept C3018332767 @default.
- W4223614665 hasConcept C31179232 @default.
- W4223614665 hasConcept C548259974 @default.
- W4223614665 hasConcept C55493867 @default.
- W4223614665 hasConcept C71924100 @default.
- W4223614665 hasConcept C86803240 @default.
- W4223614665 hasConcept C8891405 @default.
- W4223614665 hasConcept C95444343 @default.
- W4223614665 hasConcept C99971728 @default.
- W4223614665 hasConceptScore W4223614665C104317684 @default.
- W4223614665 hasConceptScore W4223614665C127561419 @default.
- W4223614665 hasConceptScore W4223614665C12823836 @default.
- W4223614665 hasConceptScore W4223614665C13373296 @default.