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- W4223635489 endingPage "1912" @default.
- W4223635489 startingPage "1912" @default.
- W4223635489 abstract "Primary liver cancers (PLCs) are steadily increasing in incidence and mortality in the world. They have a poor prognosis due to their silent nature, late discovery and resistance to common chemotherapy. At present, there are limited treatment alternatives, and the understanding of PLC molecular aspects is essential to develop more efficient drugs and therapeutic surgical and loco-regional strategies. A clear causal link with liver damage, inflammation, and regeneration has been found in the occurrence of PLC over the last few decades. Physiologically, Wingless/It (Wnt)-β-catenin signaling plays a key role in liver development, metabolic zonation and regeneration. Loss of functional homeostasis of this pathway appears to be a major driver of carcinogenesis in the liver parenchyma. In the hepatic microenvironment, molecular deregulations that exceed the Wnt signaling biological capacity can induce tumor initiation and progression. Indeed, somatic mutations are identified in key components of canonical and non-canonical Wnt signaling and in PLCs and precancerous lesions. In this review, the altered functions of Wnt/β-catenin signaling are considered in human PLCs, with emphasis on hepatocellular carcinomas (HCC), cholangiocarcinomas (CCA) and hepatoblastomas (HB). Based on recent literature, we also focused on liver cancerogenesis through Wnt deregulation. An overview of preclinical and clinical studies on approved and experimental drugs, targeting the Wnt/β-catenin cascade in PLCs, is proposed. In addition, the clinical implication of molecule inhibitors that have been shown to possess activity against the Wnt pathway in association with conventional surgical and loco-regional therapies are reviewed." @default.
- W4223635489 created "2022-04-15" @default.
- W4223635489 creator A5004690018 @default.
- W4223635489 creator A5031528101 @default.
- W4223635489 creator A5064539408 @default.
- W4223635489 creator A5078931577 @default.
- W4223635489 date "2022-04-10" @default.
- W4223635489 modified "2023-10-14" @default.
- W4223635489 title "Targeting Wnt/β-Catenin Pathways in Primary Liver Tumours: From Microenvironment Signaling to Therapeutic Agents" @default.
- W4223635489 cites W1569503463 @default.
- W4223635489 cites W1615764257 @default.
- W4223635489 cites W1931328355 @default.
- W4223635489 cites W1966248848 @default.
- W4223635489 cites W1966897236 @default.
- W4223635489 cites W1968598003 @default.
- W4223635489 cites W1974342793 @default.
- W4223635489 cites W1974532695 @default.
- W4223635489 cites W1974549459 @default.
- W4223635489 cites W1975866042 @default.
- W4223635489 cites W1976106807 @default.
- W4223635489 cites W1977613525 @default.
- W4223635489 cites W1983712244 @default.
- W4223635489 cites W1984374641 @default.
- W4223635489 cites W1990563353 @default.
- W4223635489 cites W1995158022 @default.
- W4223635489 cites W1996583924 @default.
- W4223635489 cites W1998040747 @default.
- W4223635489 cites W2006152089 @default.
- W4223635489 cites W2006419043 @default.
- W4223635489 cites W2009519656 @default.
- W4223635489 cites W2010888934 @default.
- W4223635489 cites W2011532943 @default.
- W4223635489 cites W2013708418 @default.
- W4223635489 cites W2013891209 @default.
- W4223635489 cites W2024432674 @default.
- W4223635489 cites W2027243817 @default.
- W4223635489 cites W2029492851 @default.
- W4223635489 cites W2035809306 @default.
- W4223635489 cites W2041812469 @default.
- W4223635489 cites W2045459429 @default.
- W4223635489 cites W2054307087 @default.
- W4223635489 cites W2054368385 @default.
- W4223635489 cites W2058456997 @default.
- W4223635489 cites W2059509996 @default.
- W4223635489 cites W2060997676 @default.
- W4223635489 cites W2071168599 @default.
- W4223635489 cites W2074616967 @default.
- W4223635489 cites W2084477289 @default.
- W4223635489 cites W2088629624 @default.
- W4223635489 cites W2091258025 @default.
- W4223635489 cites W2095366840 @default.
- W4223635489 cites W2096181900 @default.
- W4223635489 cites W2114003084 @default.
- W4223635489 cites W2118230770 @default.
- W4223635489 cites W2130462759 @default.
- W4223635489 cites W2131787067 @default.
- W4223635489 cites W2135835127 @default.
- W4223635489 cites W2140030329 @default.
- W4223635489 cites W2142474397 @default.
- W4223635489 cites W2148305615 @default.
- W4223635489 cites W2157843415 @default.
- W4223635489 cites W2157971450 @default.
- W4223635489 cites W2158021558 @default.
- W4223635489 cites W2164193415 @default.
- W4223635489 cites W2170388160 @default.
- W4223635489 cites W2170839518 @default.
- W4223635489 cites W2265312242 @default.
- W4223635489 cites W2310289511 @default.
- W4223635489 cites W2330642742 @default.
- W4223635489 cites W2400960638 @default.
- W4223635489 cites W2414061285 @default.
- W4223635489 cites W2419193153 @default.
- W4223635489 cites W2422294114 @default.
- W4223635489 cites W2520347413 @default.
- W4223635489 cites W2520632143 @default.
- W4223635489 cites W2520824012 @default.
- W4223635489 cites W2553776432 @default.
- W4223635489 cites W2559600465 @default.
- W4223635489 cites W2562696573 @default.
- W4223635489 cites W2575236525 @default.
- W4223635489 cites W2579027992 @default.
- W4223635489 cites W2611778286 @default.
- W4223635489 cites W2621721411 @default.
- W4223635489 cites W2753111692 @default.
- W4223635489 cites W2757400234 @default.
- W4223635489 cites W2767823610 @default.
- W4223635489 cites W2768987871 @default.
- W4223635489 cites W2772869455 @default.
- W4223635489 cites W2788930273 @default.
- W4223635489 cites W2797499614 @default.
- W4223635489 cites W2810415790 @default.
- W4223635489 cites W2888230285 @default.
- W4223635489 cites W2892219868 @default.
- W4223635489 cites W2900958958 @default.
- W4223635489 cites W2902276810 @default.
- W4223635489 cites W2916432893 @default.
- W4223635489 cites W2922620113 @default.
- W4223635489 cites W2930419027 @default.