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• W4223636700 abstract "IFN-1 responses during viral infections activate host-protective immunity, but it may also trigger autoimmune cascades in lupus erythematosus and psoriasis ( Illescas-Montes et al., 2019 Illescas-Montes R. Corona-Castro C.C. Melguizo-Rodríguez L. Ruiz C. Costela-Ruiz V.J. Infectious processes and systemic lupus erythematosus. Immunology. 2019; 158: 153-160 Crossref PubMed Scopus (52) Google Scholar ; Wang et al., 2021 Wang W.M. Li F. Jin H.Z. Role of interferon regulatory factor-mediated signaling in psoriasis. Int J Med Sci. 2021; 18: 3794-3799 Crossref PubMed Google Scholar ). Aspects of antiviral immunity can be modeled in mice through the intraperitoneal injection of the double-stranded RNA analog, poly(I:C), which provokes systemic IFN-1 production ( Kühn et al., 1995 Kühn R. Schwenk F. Aguet M. Rajewsky K. Inducible gene targeting in mice. Science. 1995; 269: 1427-1429 Crossref PubMed Scopus (1546) Google Scholar ). Utilizing this approach, we recently reported that innate epithelial barrier during a IFN-1 response was bolstered by ADAM10‒Notch signaling pathway in upper hair follicles, infundibulum (IFD), and isthmus (ISM) ( Sakamoto et al., 2021 Sakamoto K. Jin S.P. Goel S. Jo J.H. Voisin B. Kim D. et al. Disruption of the endopeptidase ADAM10-Notch signaling axis leads to skin dysbiosis and innate lymphoid cell-mediated hair follicle destruction. Immunity. 2021; 54: 2321-2337 Abstract Full Text Full Text PDF PubMed Scopus (22) Google Scholar ). However, the transcriptomic landscape of keratinocyte (KC) subsets during IFN-1 responses has not been systematically explored, the understanding of which could deepen our insight into how KCs contribute to inflammation. Thus, we subjected C57BL/6 mice to a one-time intraperitoneal injection with 200 μg of poly(I:C) or saline, prepared epidermal single-cell suspensions ( Sakamoto et al., 2022 Sakamoto K. Goel S. Funakoshi A. Honda T. Nagao K. Flow cytometry analysis of the subpopulations of mouse keratinocytes and skin immune cells. Star Protoc. 2022; 3: 101052 Crossref PubMed Scopus (3) Google Scholar ), and sorted interfollicular epidermis and the bulge (Figure 1a) to perform RNA sequencing. Obtained data were analyzed with our recently reported RNA-sequencing data on the IFD and ISM, GSE18083 ( Sakamoto et al., 2021 Sakamoto K. Jin S.P. Goel S. Jo J.H. Voisin B. Kim D. et al. Disruption of the endopeptidase ADAM10-Notch signaling axis leads to skin dysbiosis and innate lymphoid cell-mediated hair follicle destruction. Immunity. 2021; 54: 2321-2337 Abstract Full Text Full Text PDF PubMed Scopus (22) Google Scholar ). GSE180803 and GSE180435 from this study were sequenced simultaneously. All experiments procedures were approved by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (Bethesda, MD) Animal Care and Use Committee. Data processing and gene expression analyses were performed utilizing Partek Flow." @default.
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• W4223636700 date "2022-10-01" @default.
• W4223636700 modified "2023-10-09" @default.
• W4223636700 title "The Double-Stranded RNA Analog, Poly(I:C), Triggers Distinct Transcriptomic Shifts in Keratinocyte Subsets" @default.
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• W4223636700 doi "https://doi.org/10.1016/j.jid.2022.03.015" @default.
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