FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4223646071> ?p ?o ?g. }

• W4223646071 endingPage "370.e10" @default.
• W4223646071 startingPage "370.e1" @default.
• W4223646071 abstract "Reduced-intensity conditioning (RIC) regimens frequently provide insufficient disease control in patients with high-risk hematologic malignancies undergoing allogeneic hematopoietic stem cell transplantation (HSCT). We evaluated intensification of fludarabine/busulfan (Flu/Bu) RIC with targeted marrow irradiation (TMI) in a dose escalation with expansion phase I clinical trial. TMI doses were delivered at 1.5 Gy in twice daily fractions on days -10 through -7 (dose levels: 3 Gy, 4.5 Gy, and 6 Gy), Flu (30 mg/m2 for 5 days) and Bu (area under the curve, 4800 µM*minute for 2 days). Eligible patients were age ≥18 years with high-risk hematologic malignancy and compromised organ function ineligible for myeloablative transplantation (n = 26). The median patient age was 64 years (range, 25 to 76 years). Nineteen patients (73%) had active or measurable residual disease at transplantation. One-year disease-free survival and overall survival were 55% (95% confidence interval [CI], 34% to 76%) and 65% (95% CI, 46% to 85%), respectively. Day +100 and 1 year transplantation-related mortality were 4% (95% CI, 0.6% to 27%) and 8.5% (95% CI, 2% to 32%), respectively. The 1-year cumulative incidence of relapse was 43% (95% CI, 27% to 69%). Rates of grade II-IV and III-IV acute GVHD rates were 57% (95% CI, 39% to 84%) and 22% (95% CI, 9% to 53%), respectively. Whole blood immune profiling demonstrated enrichment of central/transitional memory-like T cells with higher TMI doses, which correlated with improved survival compared with control samples from patients undergoing allogeneic HSCT. Intensification of a Flu/Bu RIC regimen with TMI is feasible with a low incidence of transplantation-related mortality in medically frail patients with advanced malignancies. The recommended phase 2 TMI dose is 6 Gy." @default.
• W4223646071 created "2022-04-15" @default.
• W4223646071 creator A5000161940 @default.
• W4223646071 creator A5007528796 @default.
• W4223646071 creator A5011076004 @default.
• W4223646071 creator A5012945339 @default.
• W4223646071 creator A5013926915 @default.
• W4223646071 creator A5016048836 @default.
• W4223646071 creator A5026179638 @default.
• W4223646071 creator A5027184862 @default.
• W4223646071 creator A5030876153 @default.
• W4223646071 creator A5034264716 @default.
• W4223646071 creator A5036285568 @default.
• W4223646071 creator A5036830739 @default.
• W4223646071 creator A5039525847 @default.
• W4223646071 creator A5040099496 @default.
• W4223646071 creator A5047453846 @default.
• W4223646071 creator A5048819974 @default.
• W4223646071 creator A5058077332 @default.
• W4223646071 creator A5062918970 @default.
• W4223646071 creator A5072224075 @default.
• W4223646071 creator A5075134379 @default.
• W4223646071 creator A5076264633 @default.
• W4223646071 creator A5082911627 @default.
• W4223646071 creator A5083283435 @default.
• W4223646071 creator A5083773941 @default.
• W4223646071 date "2022-07-01" @default.
• W4223646071 modified "2023-10-02" @default.
• W4223646071 title "Targeted Marrow Irradiation Intensification of Reduced-Intensity Fludarabine/Busulfan Conditioning for Allogeneic Hematopoietic Stem Cell Transplantation" @default.
• W4223646071 cites W1959073718 @default.
• W4223646071 cites W1973177688 @default.
• W4223646071 cites W1980501529 @default.
• W4223646071 cites W1982836586 @default.
• W4223646071 cites W1991026693 @default.
• W4223646071 cites W2014751151 @default.
• W4223646071 cites W2022015347 @default.
• W4223646071 cites W2024290860 @default.
• W4223646071 cites W2028851768 @default.
• W4223646071 cites W2035502715 @default.
• W4223646071 cites W2064085613 @default.
• W4223646071 cites W2071206691 @default.
• W4223646071 cites W2075154508 @default.
• W4223646071 cites W2078356851 @default.
• W4223646071 cites W2086891287 @default.
• W4223646071 cites W2092740805 @default.
• W4223646071 cites W2101358405 @default.
• W4223646071 cites W2102124437 @default.
• W4223646071 cites W2104848762 @default.
• W4223646071 cites W2106947293 @default.
• W4223646071 cites W2107810465 @default.
• W4223646071 cites W2115852541 @default.
• W4223646071 cites W2126661483 @default.
• W4223646071 cites W2128812336 @default.
• W4223646071 cites W2140829768 @default.
• W4223646071 cites W2143034151 @default.
• W4223646071 cites W2143200412 @default.
• W4223646071 cites W2161230154 @default.
• W4223646071 cites W2162845310 @default.
• W4223646071 cites W2167685544 @default.
• W4223646071 cites W2171116665 @default.
• W4223646071 cites W2214515641 @default.
• W4223646071 cites W2493676730 @default.
• W4223646071 cites W2543219029 @default.
• W4223646071 cites W2561452209 @default.
• W4223646071 cites W2571279353 @default.
• W4223646071 cites W2590030902 @default.
• W4223646071 cites W2604874530 @default.
• W4223646071 cites W2618073389 @default.
• W4223646071 cites W2763634893 @default.
• W4223646071 cites W2796692697 @default.
• W4223646071 cites W2804242740 @default.
• W4223646071 cites W2808340953 @default.
• W4223646071 cites W2888263010 @default.
• W4223646071 cites W2892949113 @default.
• W4223646071 cites W2902321899 @default.
• W4223646071 cites W2970683397 @default.
• W4223646071 cites W2980217969 @default.
• W4223646071 cites W2996657019 @default.
• W4223646071 cites W3022929575 @default.
• W4223646071 cites W4241113165 @default.
• W4223646071 cites W4244166141 @default.
• W4223646071 cites W66769540 @default.
• W4223646071 cites W71007469 @default.
• W4223646071 doi "https://doi.org/10.1016/j.jtct.2022.04.001" @default.
• W4223646071 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35421620" @default.
• W4223646071 hasPublicationYear "2022" @default.
• W4223646071 type Work @default.
• W4223646071 citedByCount "1" @default.
• W4223646071 countsByYear W42236460712023 @default.
• W4223646071 crossrefType "journal-article" @default.
• W4223646071 hasAuthorship W4223646071A5000161940 @default.
• W4223646071 hasAuthorship W4223646071A5007528796 @default.
• W4223646071 hasAuthorship W4223646071A5011076004 @default.
• W4223646071 hasAuthorship W4223646071A5012945339 @default.
• W4223646071 hasAuthorship W4223646071A5013926915 @default.
• W4223646071 hasAuthorship W4223646071A5016048836 @default.
• W4223646071 hasAuthorship W4223646071A5026179638 @default.
• W4223646071 hasAuthorship W4223646071A5027184862 @default.

• next