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- W4223655035 startingPage "147904" @default.
- W4223655035 abstract "Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with multiple complex mechanisms involved. Among them, mitochondrial dysfunction plays an important role in ALS. Multiple studies have shown that mitochondria are closely associated with reactive oxygen species production and oxidative stress and exhibit different functional states in different genetic backgrounds. In this review we explored the roles of Ca2+, autophagy, mitochondrial quality control in the regulation of mitochondrial homeostasis and their relationship with ALS. In addition, we also summarized and analyzed the roles of protein misfolding and abnormal aggregation in the pathogenesis of ALS. Moreover, we also discussed how epigenetic mechanisms such as DNA methylation and protein post-translational modification affect initiation and progression of ALS. Nevertheless, existing events still cannot fully explain the pathogenesis of ALS at present, more studies are required to explore pathological mechanisms of ALS." @default.
- W4223655035 created "2022-04-15" @default.
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- W4223655035 creator A5037215917 @default.
- W4223655035 creator A5047738011 @default.
- W4223655035 creator A5053892310 @default.
- W4223655035 date "2022-07-01" @default.
- W4223655035 modified "2023-10-15" @default.
- W4223655035 title "The pathogenesis of amyotrophic lateral sclerosis: Mitochondrial dysfunction, protein misfolding and epigenetics" @default.
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