Matches in SemOpenAlex for { <https://semopenalex.org/work/W4223893755> ?p ?o ?g. }
- W4223893755 abstract "Humans are spending an increasing amount of time in space, where exposure to conditions of microgravity causes 1-2% bone loss per month in astronauts. Through data collected from astronauts, as well as animal and cellular experiments conducted in space, it is evident that microgravity induces skeletal deconditioning in weight-bearing bones. This review identifies contentions in current literature describing the effect of microgravity on non-weight-bearing bones, different bone compartments, as well as the skeletal recovery process in human and animal spaceflight data. Experiments in space are not readily available, and experimental designs are often limited due to logistical and technical reasons. This review introduces a plethora of on-ground research that elucidate the intricate process of bone loss, utilising technology that simulates microgravity. Observations from these studies are largely congruent to data obtained from spaceflight experiments, while offering more insights behind the molecular mechanisms leading to microgravity-induced bone loss. These insights are discussed herein, as well as how that knowledge has contributed to studies of current therapeutic agents. This review also points out discrepancies in existing data, highlighting knowledge gaps in our current understanding. Further dissection of the exact mechanisms of microgravity-induced bone loss will enable the development of more effective preventative and therapeutic measures to protect against bone loss, both in space and possibly on ground." @default.
- W4223893755 created "2022-04-19" @default.
- W4223893755 creator A5040388285 @default.
- W4223893755 creator A5051164414 @default.
- W4223893755 creator A5064144722 @default.
- W4223893755 creator A5087795224 @default.
- W4223893755 date "2022-04-05" @default.
- W4223893755 modified "2023-10-13" @default.
- W4223893755 title "The effects of microgravity on bone structure and function" @default.
- W4223893755 cites W1514359295 @default.
- W4223893755 cites W1535883647 @default.
- W4223893755 cites W1565135627 @default.
- W4223893755 cites W1583006503 @default.
- W4223893755 cites W1656320297 @default.
- W4223893755 cites W1802201872 @default.
- W4223893755 cites W1891721997 @default.
- W4223893755 cites W1913314773 @default.
- W4223893755 cites W1943458378 @default.
- W4223893755 cites W1955559333 @default.
- W4223893755 cites W1965666109 @default.
- W4223893755 cites W1966550557 @default.
- W4223893755 cites W1967733058 @default.
- W4223893755 cites W1972069068 @default.
- W4223893755 cites W1973853894 @default.
- W4223893755 cites W1974388390 @default.
- W4223893755 cites W1976048853 @default.
- W4223893755 cites W1977489392 @default.
- W4223893755 cites W1978795695 @default.
- W4223893755 cites W1981069600 @default.
- W4223893755 cites W1981100674 @default.
- W4223893755 cites W1982180891 @default.
- W4223893755 cites W1982370874 @default.
- W4223893755 cites W1985153461 @default.
- W4223893755 cites W1988170766 @default.
- W4223893755 cites W1991060237 @default.
- W4223893755 cites W1992401482 @default.
- W4223893755 cites W1992567157 @default.
- W4223893755 cites W1994174491 @default.
- W4223893755 cites W1994206981 @default.
- W4223893755 cites W1997364815 @default.
- W4223893755 cites W1997921434 @default.
- W4223893755 cites W1999487669 @default.
- W4223893755 cites W2000647744 @default.
- W4223893755 cites W2001655022 @default.
- W4223893755 cites W2004383794 @default.
- W4223893755 cites W2005603603 @default.
- W4223893755 cites W2007451978 @default.
- W4223893755 cites W2014313490 @default.
- W4223893755 cites W2014833779 @default.
- W4223893755 cites W2015102924 @default.
- W4223893755 cites W2018109687 @default.
- W4223893755 cites W2026424365 @default.
- W4223893755 cites W20286842 @default.
- W4223893755 cites W2029259548 @default.
- W4223893755 cites W2030106417 @default.
- W4223893755 cites W2032242363 @default.
- W4223893755 cites W2035119391 @default.
- W4223893755 cites W2037324935 @default.
- W4223893755 cites W2037866214 @default.
- W4223893755 cites W2038965450 @default.
- W4223893755 cites W2043991983 @default.
- W4223893755 cites W2048259913 @default.
- W4223893755 cites W2048299560 @default.
- W4223893755 cites W2051114659 @default.
- W4223893755 cites W2051545868 @default.
- W4223893755 cites W2053696441 @default.
- W4223893755 cites W2055658787 @default.
- W4223893755 cites W2061379246 @default.
- W4223893755 cites W2065699183 @default.
- W4223893755 cites W2068682682 @default.
- W4223893755 cites W2069068175 @default.
- W4223893755 cites W2072067396 @default.
- W4223893755 cites W2074494444 @default.
- W4223893755 cites W2076372662 @default.
- W4223893755 cites W2076827064 @default.
- W4223893755 cites W2078536317 @default.
- W4223893755 cites W2080199971 @default.
- W4223893755 cites W2081263377 @default.
- W4223893755 cites W2083960671 @default.
- W4223893755 cites W2085882515 @default.
- W4223893755 cites W2087560312 @default.
- W4223893755 cites W2087665466 @default.
- W4223893755 cites W2092188139 @default.
- W4223893755 cites W2093433426 @default.
- W4223893755 cites W2093476254 @default.
- W4223893755 cites W2094009347 @default.
- W4223893755 cites W2095857644 @default.
- W4223893755 cites W2102592206 @default.
- W4223893755 cites W2104556914 @default.
- W4223893755 cites W2105834654 @default.
- W4223893755 cites W2106440946 @default.
- W4223893755 cites W2108403721 @default.
- W4223893755 cites W2108409970 @default.
- W4223893755 cites W2110113238 @default.
- W4223893755 cites W2114349208 @default.
- W4223893755 cites W2121610198 @default.
- W4223893755 cites W2125520219 @default.
- W4223893755 cites W2130716026 @default.
- W4223893755 cites W2135671879 @default.
- W4223893755 cites W2139865845 @default.