FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4223894449> ?p ?o ?g. }

• W4223894449 endingPage "1320" @default.
• W4223894449 startingPage "1320" @default.
• W4223894449 abstract "Neurons are highly polarized cells requiring precise regulation of trafficking and targeting of membrane proteins to generate and maintain different and specialized compartments, such as axons and dendrites. Disruption of the Golgi apparatus (GA) secretory pathway in developing neurons alters axon/dendritic formation. Therefore, detailed knowledge of the mechanisms underlying vesicles exiting from the GA is crucial for understanding neuronal polarity. In this study, we analyzed the role of Brefeldin A-Ribosylated Substrate (CtBP1-S/BARS), a member of the C-terminal-binding protein family, in the regulation of neuronal morphological polarization and the exit of membrane proteins from the Trans Golgi Network. Here, we show that BARS is expressed during neuronal development in vitro and that RNAi suppression of BARS inhibits axonal and dendritic elongation in hippocampal neuronal cultures as well as largely perturbed neuronal migration and multipolar-to-bipolar transition during cortical development in situ. In addition, using plasma membrane (PM) proteins fused to GFP and engineered with reversible aggregation domains, we observed that expression of fission dominant-negative BARS delays the exit of dendritic and axonal membrane protein-containing carriers from the GA. Taken together, these data provide the first set of evidence suggesting a role for BARS in neuronal development by regulating post-Golgi membrane trafficking." @default.
• W4223894449 created "2022-04-19" @default.
• W4223894449 creator A5012979018 @default.
• W4223894449 creator A5022723432 @default.
• W4223894449 creator A5038386950 @default.
• W4223894449 creator A5040282035 @default.
• W4223894449 creator A5046167549 @default.
• W4223894449 creator A5050387519 @default.
• W4223894449 creator A5054041610 @default.
• W4223894449 creator A5058705198 @default.
• W4223894449 creator A5077839950 @default.
• W4223894449 creator A5087807774 @default.
• W4223894449 date "2022-04-13" @default.
• W4223894449 modified "2023-10-06" @default.
• W4223894449 title "BARS Influences Neuronal Development by Regulation of Post-Golgi Trafficking" @default.
• W4223894449 cites W1946564394 @default.
• W4223894449 cites W1983869713 @default.
• W4223894449 cites W1990753351 @default.
• W4223894449 cites W2001888120 @default.
• W4223894449 cites W2007617487 @default.
• W4223894449 cites W2023013803 @default.
• W4223894449 cites W2025030210 @default.
• W4223894449 cites W2025868352 @default.
• W4223894449 cites W2031525292 @default.
• W4223894449 cites W2037091801 @default.
• W4223894449 cites W2043270630 @default.
• W4223894449 cites W2047447549 @default.
• W4223894449 cites W2060705097 @default.
• W4223894449 cites W2070865523 @default.
• W4223894449 cites W2074395695 @default.
• W4223894449 cites W2075705981 @default.
• W4223894449 cites W2076616447 @default.
• W4223894449 cites W2095711264 @default.
• W4223894449 cites W2099903706 @default.
• W4223894449 cites W2110221241 @default.
• W4223894449 cites W2110728570 @default.
• W4223894449 cites W2115457039 @default.
• W4223894449 cites W2115549977 @default.
• W4223894449 cites W2124813164 @default.
• W4223894449 cites W2133087541 @default.
• W4223894449 cites W2136329192 @default.
• W4223894449 cites W2142826449 @default.
• W4223894449 cites W2149290739 @default.
• W4223894449 cites W2156214261 @default.
• W4223894449 cites W2171577293 @default.
• W4223894449 cites W2334015356 @default.
• W4223894449 cites W2412227306 @default.
• W4223894449 cites W2469216125 @default.
• W4223894449 cites W2511994987 @default.
• W4223894449 cites W2591536154 @default.
• W4223894449 cites W2625494551 @default.
• W4223894449 cites W2753051071 @default.
• W4223894449 cites W2767171326 @default.
• W4223894449 cites W2810270082 @default.
• W4223894449 cites W2941495623 @default.
• W4223894449 cites W2958571635 @default.
• W4223894449 cites W2970929780 @default.
• W4223894449 cites W2988371302 @default.
• W4223894449 cites W3000016685 @default.
• W4223894449 doi "https://doi.org/10.3390/cells11081320" @default.
• W4223894449 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35455998" @default.
• W4223894449 hasPublicationYear "2022" @default.
• W4223894449 type Work @default.
• W4223894449 citedByCount "1" @default.
• W4223894449 countsByYear W42238944492023 @default.
• W4223894449 crossrefType "journal-article" @default.
• W4223894449 hasAuthorship W4223894449A5012979018 @default.
• W4223894449 hasAuthorship W4223894449A5022723432 @default.
• W4223894449 hasAuthorship W4223894449A5038386950 @default.
• W4223894449 hasAuthorship W4223894449A5040282035 @default.
• W4223894449 hasAuthorship W4223894449A5046167549 @default.
• W4223894449 hasAuthorship W4223894449A5050387519 @default.
• W4223894449 hasAuthorship W4223894449A5054041610 @default.
• W4223894449 hasAuthorship W4223894449A5058705198 @default.
• W4223894449 hasAuthorship W4223894449A5077839950 @default.
• W4223894449 hasAuthorship W4223894449A5087807774 @default.
• W4223894449 hasBestOaLocation W42238944491 @default.
• W4223894449 hasConcept C119062480 @default.
• W4223894449 hasConcept C124682485 @default.
• W4223894449 hasConcept C148762608 @default.
• W4223894449 hasConcept C158617107 @default.
• W4223894449 hasConcept C169760540 @default.
• W4223894449 hasConcept C185592680 @default.
• W4223894449 hasConcept C2781373781 @default.
• W4223894449 hasConcept C6492254 @default.
• W4223894449 hasConcept C86803240 @default.
• W4223894449 hasConcept C95444343 @default.
• W4223894449 hasConceptScore W4223894449C119062480 @default.
• W4223894449 hasConceptScore W4223894449C124682485 @default.
• W4223894449 hasConceptScore W4223894449C148762608 @default.
• W4223894449 hasConceptScore W4223894449C158617107 @default.
• W4223894449 hasConceptScore W4223894449C169760540 @default.
• W4223894449 hasConceptScore W4223894449C185592680 @default.
• W4223894449 hasConceptScore W4223894449C2781373781 @default.
• W4223894449 hasConceptScore W4223894449C6492254 @default.
• W4223894449 hasConceptScore W4223894449C86803240 @default.
• W4223894449 hasConceptScore W4223894449C95444343 @default.
• W4223894449 hasFunder F4320320891 @default.

• next