Matches in SemOpenAlex for { <https://semopenalex.org/work/W4223896145> ?p ?o ?g. }
- W4223896145 endingPage "742" @default.
- W4223896145 startingPage "731" @default.
- W4223896145 abstract "ATP citrate lyase (ACLY) is a key enzyme in cellular metabolism, being the main source of acetyl-Coenzyme A, an important precursor for fatty acid, cholesterol, and isoprenoid biosynthesis, and it is also involved in protein acetylation. Its expression changes are related to hyperlipidemia and cardiovascular diseases. Other studies have shown that ACLY is closely related to the occurrence of cancer: the increase in lipid synthesis provides the necessary building blocks for cell growth and division. Therefore, finding effective ACLY inhibitors has very important application prospects for lipid-related pathologies and cancer.This review covers patents concerning ACLY inhibitors and alternative strategies to modulate ACLY activity, with their potential therapeutic applications.In recent years, ACLY as a drug target has become a hot spot in the research of innovative drugs for disorders of glucose and lipid metabolism. Many types of small-molecule ACLY inhibitors have been discovered, but few ACLY inhibitors proved to be highly effective in vitro and in vivo, since their main limitations were low cell penetration and low affinity to ACLY. The search for new effective ACLY inhibitors is of great significance and has broad application prospects for the treatment of hyperlipidemia and cancer." @default.
- W4223896145 created "2022-04-19" @default.
- W4223896145 creator A5070335184 @default.
- W4223896145 date "2022-04-25" @default.
- W4223896145 modified "2023-10-06" @default.
- W4223896145 title "ATP-citrate lyase (ACLY) inhibitors as therapeutic agents: a patenting perspective" @default.
- W4223896145 cites W136372353 @default.
- W4223896145 cites W1511256877 @default.
- W4223896145 cites W1530265295 @default.
- W4223896145 cites W1569698669 @default.
- W4223896145 cites W1595100801 @default.
- W4223896145 cites W1973054593 @default.
- W4223896145 cites W1985124617 @default.
- W4223896145 cites W1996782134 @default.
- W4223896145 cites W2011750387 @default.
- W4223896145 cites W2021740841 @default.
- W4223896145 cites W2028874440 @default.
- W4223896145 cites W2037502917 @default.
- W4223896145 cites W2056780561 @default.
- W4223896145 cites W2058498754 @default.
- W4223896145 cites W2064318855 @default.
- W4223896145 cites W2072451938 @default.
- W4223896145 cites W2086222405 @default.
- W4223896145 cites W2086546138 @default.
- W4223896145 cites W2103292784 @default.
- W4223896145 cites W2138110344 @default.
- W4223896145 cites W2144575277 @default.
- W4223896145 cites W2151216008 @default.
- W4223896145 cites W2160518775 @default.
- W4223896145 cites W2345198528 @default.
- W4223896145 cites W2397446494 @default.
- W4223896145 cites W2558991743 @default.
- W4223896145 cites W2568968070 @default.
- W4223896145 cites W2584841803 @default.
- W4223896145 cites W2786064307 @default.
- W4223896145 cites W2889204304 @default.
- W4223896145 cites W2911157836 @default.
- W4223896145 cites W2921130252 @default.
- W4223896145 cites W2922997410 @default.
- W4223896145 cites W2930346360 @default.
- W4223896145 cites W2932952736 @default.
- W4223896145 cites W2944583391 @default.
- W4223896145 cites W2951249907 @default.
- W4223896145 cites W2952892773 @default.
- W4223896145 cites W2969489705 @default.
- W4223896145 cites W2971953119 @default.
- W4223896145 cites W2973169637 @default.
- W4223896145 cites W2974230592 @default.
- W4223896145 cites W2984799663 @default.
- W4223896145 cites W2992219911 @default.
- W4223896145 cites W2994296129 @default.
- W4223896145 cites W3004605738 @default.
- W4223896145 cites W3013314107 @default.
- W4223896145 cites W3023850866 @default.
- W4223896145 cites W3037068505 @default.
- W4223896145 cites W3097152157 @default.
- W4223896145 cites W3104502335 @default.
- W4223896145 cites W3111307620 @default.
- W4223896145 cites W3111562266 @default.
- W4223896145 cites W3118835083 @default.
- W4223896145 cites W3123926396 @default.
- W4223896145 cites W3160721338 @default.
- W4223896145 cites W3162043625 @default.
- W4223896145 cites W3173894971 @default.
- W4223896145 cites W3189486135 @default.
- W4223896145 cites W3198977051 @default.
- W4223896145 cites W3205369390 @default.
- W4223896145 cites W3209395172 @default.
- W4223896145 cites W3217532327 @default.
- W4223896145 cites W4241247951 @default.
- W4223896145 doi "https://doi.org/10.1080/13543776.2022.2067478" @default.
- W4223896145 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35436171" @default.
- W4223896145 hasPublicationYear "2022" @default.
- W4223896145 type Work @default.
- W4223896145 citedByCount "14" @default.
- W4223896145 countsByYear W42238961452022 @default.
- W4223896145 countsByYear W42238961452023 @default.
- W4223896145 crossrefType "journal-article" @default.
- W4223896145 hasAuthorship W4223896145A5070335184 @default.
- W4223896145 hasConcept C111133373 @default.
- W4223896145 hasConcept C181199279 @default.
- W4223896145 hasConcept C185592680 @default.
- W4223896145 hasConcept C204999636 @default.
- W4223896145 hasConcept C2776941171 @default.
- W4223896145 hasConcept C2777269803 @default.
- W4223896145 hasConcept C4733338 @default.
- W4223896145 hasConcept C48289651 @default.
- W4223896145 hasConcept C55493867 @default.
- W4223896145 hasConcept C86803240 @default.
- W4223896145 hasConceptScore W4223896145C111133373 @default.
- W4223896145 hasConceptScore W4223896145C181199279 @default.
- W4223896145 hasConceptScore W4223896145C185592680 @default.
- W4223896145 hasConceptScore W4223896145C204999636 @default.
- W4223896145 hasConceptScore W4223896145C2776941171 @default.
- W4223896145 hasConceptScore W4223896145C2777269803 @default.
- W4223896145 hasConceptScore W4223896145C4733338 @default.
- W4223896145 hasConceptScore W4223896145C48289651 @default.
- W4223896145 hasConceptScore W4223896145C55493867 @default.