Matches in SemOpenAlex for { <https://semopenalex.org/work/W4223903886> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W4223903886 abstract "Neurovascular coupling (NVC) is a mechanism that, amongst other known and latent critical functions, ensures activated brain regions are adequately supplied with oxygen and glucose. This biological phenomenon underpins non-invasive perfusion-related neuroimaging techniques and recent reports have implicated NVC impairment in several neurodegenerative disorders. Yet, much remains unknown regarding NVC in health and disease, and only recently has there been burgeoning recognition of a close interplay with brain thermodynamics. Accordingly, we developed a novel multi-modal approach to systematically modulate cortical temperature and interrogate the spatiotemporal dynamics of sensory-evoked NVC. We show that changes in cortical temperature profoundly and intricately modulate NVC, with low temperatures associated with diminished oxygen delivery, and high temperatures inducing a distinct vascular oscillation. These observations provide novel insights into the relationship between NVC and brain thermodynamics, with important implications for brain temperature related therapies, functional biomarkers of elevated brain temperature, and in-vivo methods to study neurovascular coupling." @default.
- W4223903886 created "2022-04-19" @default.
- W4223903886 creator A5010250498 @default.
- W4223903886 creator A5013005945 @default.
- W4223903886 creator A5040680926 @default.
- W4223903886 creator A5044287711 @default.
- W4223903886 creator A5063924897 @default.
- W4223903886 creator A5078818236 @default.
- W4223903886 creator A5091623945 @default.
- W4223903886 date "2022-04-15" @default.
- W4223903886 modified "2023-10-16" @default.
- W4223903886 title "Bidirectional alterations in brain temperature profoundly modulate spatiotemporal neurovascular responses in-vivo: Implications for theragnostics" @default.
- W4223903886 doi "https://doi.org/10.1101/2022.04.14.488315" @default.
- W4223903886 hasPublicationYear "2022" @default.
- W4223903886 type Work @default.
- W4223903886 citedByCount "0" @default.
- W4223903886 crossrefType "posted-content" @default.
- W4223903886 hasAuthorship W4223903886A5010250498 @default.
- W4223903886 hasAuthorship W4223903886A5013005945 @default.
- W4223903886 hasAuthorship W4223903886A5040680926 @default.
- W4223903886 hasAuthorship W4223903886A5044287711 @default.
- W4223903886 hasAuthorship W4223903886A5063924897 @default.
- W4223903886 hasAuthorship W4223903886A5078818236 @default.
- W4223903886 hasAuthorship W4223903886A5091623945 @default.
- W4223903886 hasBestOaLocation W42239038861 @default.
- W4223903886 hasConcept C105572291 @default.
- W4223903886 hasConcept C105702510 @default.
- W4223903886 hasConcept C120843803 @default.
- W4223903886 hasConcept C131584629 @default.
- W4223903886 hasConcept C15744967 @default.
- W4223903886 hasConcept C169760540 @default.
- W4223903886 hasConcept C191897082 @default.
- W4223903886 hasConcept C192562407 @default.
- W4223903886 hasConcept C522805319 @default.
- W4223903886 hasConcept C58693492 @default.
- W4223903886 hasConcept C71924100 @default.
- W4223903886 hasConceptScore W4223903886C105572291 @default.
- W4223903886 hasConceptScore W4223903886C105702510 @default.
- W4223903886 hasConceptScore W4223903886C120843803 @default.
- W4223903886 hasConceptScore W4223903886C131584629 @default.
- W4223903886 hasConceptScore W4223903886C15744967 @default.
- W4223903886 hasConceptScore W4223903886C169760540 @default.
- W4223903886 hasConceptScore W4223903886C191897082 @default.
- W4223903886 hasConceptScore W4223903886C192562407 @default.
- W4223903886 hasConceptScore W4223903886C522805319 @default.
- W4223903886 hasConceptScore W4223903886C58693492 @default.
- W4223903886 hasConceptScore W4223903886C71924100 @default.
- W4223903886 hasLocation W42239038861 @default.
- W4223903886 hasOpenAccess W4223903886 @default.
- W4223903886 hasPrimaryLocation W42239038861 @default.
- W4223903886 hasRelatedWork W1998588297 @default.
- W4223903886 hasRelatedWork W2046104092 @default.
- W4223903886 hasRelatedWork W2101375808 @default.
- W4223903886 hasRelatedWork W2105220251 @default.
- W4223903886 hasRelatedWork W2120476994 @default.
- W4223903886 hasRelatedWork W2128226393 @default.
- W4223903886 hasRelatedWork W2318288481 @default.
- W4223903886 hasRelatedWork W2417335326 @default.
- W4223903886 hasRelatedWork W3182085149 @default.
- W4223903886 hasRelatedWork W48499914 @default.
- W4223903886 isParatext "false" @default.
- W4223903886 isRetracted "false" @default.
- W4223903886 workType "article" @default.