FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4223905997> ?p ?o ?g. }

• W4223905997 endingPage "341" @default.
• W4223905997 startingPage "340" @default.
• W4223905997 abstract "Central MessageTricuspid regurgitation is significantly morbid in hypoplastic left heart syndrome. Advanced image reconstruction may facilitate development of better surgical techniques to yield a durable repair.See Article page 324. In this issue of JTCVS Open, Ross and coworkers1Ross C.J. Trimble E.J. Johnson E.L. Baumwart R. Jolley M.A. Mir A. et al.A pilot investigation of the tricuspid valve annulus in newborns with hypoplastic left heart syndrome.J Thorac Cardiovasc Surg Open. 2022; 10: 324-339Scopus (1) Google Scholar examined the mechanics of the tricuspid valve annulus in 8 infants with hypoplastic left heart syndrome (HLHS) and compared it with that of 4 normal newborns. Among other findings, annular circumference in patients with HLHS was 20% to 30% larger and anteroposterior diameter 35% to 45% greater than in normal hearts. Normal annuli remained elliptical throughout the cardiac cycle, with major axis in the septal–lateral direction. In HLHS, the major axis was instead in the anteroposterior direction and decreased during isovolumic contraction, ie, the annulus became more circular. The annulus was flatter in mid-diastole and more “bent” (off-plane) at valve closure. Significant tricuspid regurgitation (TR) develops in approximately 30% of HLHS. Using conventional imaging, the most common reported preoperative pathology is anterior leaflet prolapse, followed by septal leaflet tethering, septal leaflet prolapse, annular dilation, and cleft anterior leaflet.2Mah K. Khoo N.S. Martin B.J. Maruyama M. Alvarez S. Rebeyka I.M. et al.Insights from 3D echocardiography in hypoplastic left heart syndrome patients undergoing TV repair.Pediatr Cardiol. 2022; 43: 735-743https://doi.org/10.1007/s00246-021-02780-1Crossref PubMed Scopus (2) Google Scholar,3Ono M. Mayr B. Burri M. Piber N. Rohlig C. Strbad M. et al.Tricuspid valve repair in children with hypoplastic left heart syndrome: impact of timing and mechanism on outcome.Eur J Cardiothorac Surg. 2020; 57: 1083-1090Crossref PubMed Scopus (6) Google Scholar Effective repair has been challenging. Combining the results from 3 studies published within the past year, the unadjusted incidence of moderate-to-severe TR after valvuloplasty was 52 of 96 patients (54%).2Mah K. Khoo N.S. Martin B.J. Maruyama M. Alvarez S. Rebeyka I.M. et al.Insights from 3D echocardiography in hypoplastic left heart syndrome patients undergoing TV repair.Pediatr Cardiol. 2022; 43: 735-743https://doi.org/10.1007/s00246-021-02780-1Crossref PubMed Scopus (2) Google Scholar, 3Ono M. Mayr B. Burri M. Piber N. Rohlig C. Strbad M. et al.Tricuspid valve repair in children with hypoplastic left heart syndrome: impact of timing and mechanism on outcome.Eur J Cardiothorac Surg. 2020; 57: 1083-1090Crossref PubMed Scopus (6) Google Scholar, 4Wamala I. Friedman K.G. Saeed M.Y. Gauvreau K. Gellis L. Borisuk M. et al.Tricuspid valve repair concomitant with the Norwood operation among babies with hypoplastic left heart syndrome.Eur J Cardiothorac Surg. February 13, 2022; ([Epub ahead of print])Crossref PubMed Scopus (1) Google Scholar At 10 years, transplant-free survival is lowest (38%) when valvuloplasty is performed at stage 1 for single-ventricle defects.5Sinha R. Altin H.F. McCracken C. Well A. Rosenblum J. Kanter K. et al.Effect of atrioventricular valve repair on multistage palliation results of single-ventricle defects.Ann Thorac Surg. 2021; 111: 662-670Abstract Full Text Full Text PDF PubMed Scopus (5) Google Scholar The pathophysiologic pathway to TR likely begins in utero, because some babies with HLHS are born with TR. In utero, the right ventricle (RV) already has a 50% excess volume load that lasts for months. After birth, when pulmonary vascular resistance drops, the volume load is 2 to 3 times normal. After the stage 1 operation, several more months pass with the volume and pressure load. (The pressure load likely contributes but not dominantly, ie, patients with tetralogy normally don't get progressive TR). TR itself adds more to the volume load; so does RV dysfunction. The volume load deforms the RV geometry, dilates the annulus, changes its shape, and alters papillary muscle orientations. While biological adaptation has been shown to occur in the mitral valve, it is unclear whether the tricuspid valve in HLHS does so and does so sufficiently.6Chaput M. Handschumacher M.D. Tournoux F. Hua L. Guerrero J.L. Vlahakes G.J. et al.Mitral leaflet adaptation to ventricular remodeling: occurrence and adequacy in patients with functional mitral regurgitation.Circulation. 2008; 118: 845-852Crossref PubMed Scopus (208) Google Scholar While the stage II operation removes much of the volume load, by then “the cat's out of the bag,” ie, some of the changes are permanent. Simplistic procedures such as posterior annuloplasty and commissuroplasty often do not yield a lasting result. The current work by Ross and coworkers adds important information to the behavior of the tricuspid apparatus in infants with HLHS. For image acquisition, they used “4-dimensional” echocardiography, then performed manual segmentation at 5 time points to reconstruct the time-related shape of the annulus. Similar studies had been performed in the past, but at only 1 or 2 time points.7Kutty S. Colen T. Thompson R.B. Tham E. Li L. Vigarnsorn C. et al.Tricuspid regurgitation in hypoplastic left heart syndrome: mechanistic insights from 3-dimensional echocardiography and relationship with outcomes.Circ Cardiovasc Imaging. 2014; 7: 765-772Crossref PubMed Scopus (37) Google Scholar The current study effectively shows us how the annulus behaves throughout the cardiac cycle. The process is time-intensive and was limited to the annulus. As mentioned by the authors, a study published just months ago accelerates the workflow using a deep learning technique (fully convolutional network) and reconstructs individual leaflet anatomy (Figure 1).8Herz C. Pace D.F. Nam H.H. Lasso A. Dinh L.A. Flynn M. et al.Segmentation of tricuspid valve leaflets from transthoracic 3D echocardiograms of children with hypoplastic left heart syndrome using deep learning.Front Cardiovasc Med. 2021; 8: 1-12https://doi.org/10.3389/fcvm.2021.735587Crossref Google Scholar Once this technique is improved and extended to analyzing the subvalvar apparatus and RV, one may hope to use the findings to design surgical techniques to intelligently refashion the tricuspid valve in HLHS, rather than just putting a finger in the dyke. A pilot investigation of the tricuspid valve annulus in newborns with hypoplastic left heart syndromeJTCVS OpenVol. 10PreviewHypoplastic left heart syndrome (HLHS) is a congenital disease characterized by an underdevelopment of the anatomical components inside the left heart. Approximately 30% of newborns with HLHS will develop tricuspid regurgitation, and it is currently unknown how the valve annulus mechanics and geometry are associated with regurgitation. Thus, we present an engineering mechanics-based analysis approach to quantify the mechanics and geometry of the HLHS-afflicted tricuspid valve (TV), using 4-dimensional echocardiograms. Full-Text PDF Open Access" @default.
• W4223905997 created "2022-04-19" @default.
• W4223905997 creator A5030596147 @default.
• W4223905997 date "2022-06-01" @default.
• W4223905997 modified "2023-09-26" @default.
• W4223905997 title "Commentary: Tricuspid regurgitation in hypoplastic left heart syndrome: Getting beyond a finger in the dyke" @default.
• W4223905997 cites W2042265764 @default.
• W4223905997 cites W2127821952 @default.
• W4223905997 cites W3005418106 @default.
• W4223905997 cites W3027538150 @default.
• W4223905997 cites W3216342857 @default.
• W4223905997 cites W4200027634 @default.
• W4223905997 cites W4210821089 @default.
• W4223905997 cites W4213453064 @default.
• W4223905997 doi "https://doi.org/10.1016/j.xjon.2022.04.004" @default.
• W4223905997 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36004252" @default.
• W4223905997 hasPublicationYear "2022" @default.
• W4223905997 type Work @default.
• W4223905997 citedByCount "0" @default.
• W4223905997 crossrefType "journal-article" @default.
• W4223905997 hasAuthorship W4223905997A5030596147 @default.
• W4223905997 hasBestOaLocation W42239059971 @default.
• W4223905997 hasConcept C126322002 @default.
• W4223905997 hasConcept C164705383 @default.
• W4223905997 hasConcept C2779545397 @default.
• W4223905997 hasConcept C2780074459 @default.
• W4223905997 hasConcept C2780168065 @default.
• W4223905997 hasConcept C71924100 @default.
• W4223905997 hasConceptScore W4223905997C126322002 @default.
• W4223905997 hasConceptScore W4223905997C164705383 @default.
• W4223905997 hasConceptScore W4223905997C2779545397 @default.
• W4223905997 hasConceptScore W4223905997C2780074459 @default.
• W4223905997 hasConceptScore W4223905997C2780168065 @default.
• W4223905997 hasConceptScore W4223905997C71924100 @default.
• W4223905997 hasLocation W42239059971 @default.
• W4223905997 hasLocation W42239059972 @default.
• W4223905997 hasLocation W42239059973 @default.
• W4223905997 hasOpenAccess W4223905997 @default.
• W4223905997 hasPrimaryLocation W42239059971 @default.
• W4223905997 hasRelatedWork W1982374250 @default.
• W4223905997 hasRelatedWork W2078107890 @default.
• W4223905997 hasRelatedWork W2084928317 @default.
• W4223905997 hasRelatedWork W2325575566 @default.
• W4223905997 hasRelatedWork W2326553220 @default.
• W4223905997 hasRelatedWork W2530681970 @default.
• W4223905997 hasRelatedWork W2789570761 @default.
• W4223905997 hasRelatedWork W3022955224 @default.
• W4223905997 hasRelatedWork W4255968011 @default.
• W4223905997 hasRelatedWork W4322727868 @default.
• W4223905997 hasVolume "10" @default.
• W4223905997 isParatext "false" @default.
• W4223905997 isRetracted "false" @default.
• W4223905997 workType "article" @default.