Matches in SemOpenAlex for { <https://semopenalex.org/work/W4223908036> ?p ?o ?g. }
- W4223908036 endingPage "758" @default.
- W4223908036 startingPage "748" @default.
- W4223908036 abstract "Methyltransferase-like 3 (METTL3) catalyses N6-methyladenosine (m6 A) modification on messenger RNA (mRNA) and participates in a wide range of biological functions via epigenetically regulating gene expression. Recent studies suggested that dysregulation of METTL3 is associated with multiple human cancers; however, the role of METTL3 in lung cancer remains unclear. In the present study, through transcriptome analysis of lung cancer patients, we found that METTL3 is overexpressed in lung cancer patients and is associated with poor patient survival. More importantly, combining both in vitro and in vivo models, we revealed that in lung cancer cells, METTL3 overexpression activates PI3K/AKT/mTOR pathway and mTOR-mediated protein synthesis. Mechanistically, METTL3 promotes PI3K expression by introducing m6 A modification in PI3K 3' untranslated region (3' UTR). Elevated PI3K level then activates downstream AKT and mTOR signalling pathway and results in rapid cancer cell proliferation and metastasis. Taken together, our study reveals that METTL3-mediated m6 A methylation promotes lung cancer progression via activating PI3K/AKT/mTOR pathway." @default.
- W4223908036 created "2022-04-19" @default.
- W4223908036 creator A5006671485 @default.
- W4223908036 creator A5009334952 @default.
- W4223908036 creator A5069778682 @default.
- W4223908036 date "2022-05-23" @default.
- W4223908036 modified "2023-09-29" @default.
- W4223908036 title "Methyltransferase‐like 3 promotes the progression of lung cancer via activating <scp>PI3K</scp>/<scp>AKT</scp>/<scp>mTOR</scp> pathway" @default.
- W4223908036 cites W1972774425 @default.
- W4223908036 cites W1991533202 @default.
- W4223908036 cites W2000263590 @default.
- W4223908036 cites W2007749789 @default.
- W4223908036 cites W2014080468 @default.
- W4223908036 cites W2019240356 @default.
- W4223908036 cites W2044545697 @default.
- W4223908036 cites W2088460013 @default.
- W4223908036 cites W2104442096 @default.
- W4223908036 cites W2125149303 @default.
- W4223908036 cites W2146734285 @default.
- W4223908036 cites W2154572127 @default.
- W4223908036 cites W2156918228 @default.
- W4223908036 cites W2629851442 @default.
- W4223908036 cites W2761180922 @default.
- W4223908036 cites W2762830435 @default.
- W4223908036 cites W2895926103 @default.
- W4223908036 cites W2917695674 @default.
- W4223908036 cites W2942683196 @default.
- W4223908036 cites W2979436219 @default.
- W4223908036 cites W2984861736 @default.
- W4223908036 cites W2990016380 @default.
- W4223908036 cites W2993675487 @default.
- W4223908036 cites W3001859997 @default.
- W4223908036 cites W3003807413 @default.
- W4223908036 cites W3005240107 @default.
- W4223908036 cites W3009703063 @default.
- W4223908036 cites W3014891010 @default.
- W4223908036 cites W3045459672 @default.
- W4223908036 cites W3081921226 @default.
- W4223908036 cites W3087526211 @default.
- W4223908036 cites W3092497389 @default.
- W4223908036 cites W3093757759 @default.
- W4223908036 cites W3119005666 @default.
- W4223908036 cites W3168290835 @default.
- W4223908036 cites W3171247460 @default.
- W4223908036 cites W3191670648 @default.
- W4223908036 cites W3200561261 @default.
- W4223908036 cites W4294214970 @default.
- W4223908036 doi "https://doi.org/10.1111/1440-1681.13647" @default.
- W4223908036 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35434840" @default.
- W4223908036 hasPublicationYear "2022" @default.
- W4223908036 type Work @default.
- W4223908036 citedByCount "5" @default.
- W4223908036 countsByYear W42239080362022 @default.
- W4223908036 countsByYear W42239080362023 @default.
- W4223908036 crossrefType "journal-article" @default.
- W4223908036 hasAuthorship W4223908036A5006671485 @default.
- W4223908036 hasAuthorship W4223908036A5009334952 @default.
- W4223908036 hasAuthorship W4223908036A5069778682 @default.
- W4223908036 hasConcept C104317684 @default.
- W4223908036 hasConcept C121608353 @default.
- W4223908036 hasConcept C143998085 @default.
- W4223908036 hasConcept C185592680 @default.
- W4223908036 hasConcept C2776256026 @default.
- W4223908036 hasConcept C33288867 @default.
- W4223908036 hasConcept C502942594 @default.
- W4223908036 hasConcept C54355233 @default.
- W4223908036 hasConcept C55493867 @default.
- W4223908036 hasConcept C62478195 @default.
- W4223908036 hasConcept C71924100 @default.
- W4223908036 hasConcept C75217442 @default.
- W4223908036 hasConcept C86554907 @default.
- W4223908036 hasConcept C86803240 @default.
- W4223908036 hasConcept C91965660 @default.
- W4223908036 hasConcept C95444343 @default.
- W4223908036 hasConceptScore W4223908036C104317684 @default.
- W4223908036 hasConceptScore W4223908036C121608353 @default.
- W4223908036 hasConceptScore W4223908036C143998085 @default.
- W4223908036 hasConceptScore W4223908036C185592680 @default.
- W4223908036 hasConceptScore W4223908036C2776256026 @default.
- W4223908036 hasConceptScore W4223908036C33288867 @default.
- W4223908036 hasConceptScore W4223908036C502942594 @default.
- W4223908036 hasConceptScore W4223908036C54355233 @default.
- W4223908036 hasConceptScore W4223908036C55493867 @default.
- W4223908036 hasConceptScore W4223908036C62478195 @default.
- W4223908036 hasConceptScore W4223908036C71924100 @default.
- W4223908036 hasConceptScore W4223908036C75217442 @default.
- W4223908036 hasConceptScore W4223908036C86554907 @default.
- W4223908036 hasConceptScore W4223908036C86803240 @default.
- W4223908036 hasConceptScore W4223908036C91965660 @default.
- W4223908036 hasConceptScore W4223908036C95444343 @default.
- W4223908036 hasIssue "7" @default.
- W4223908036 hasLocation W42239080361 @default.
- W4223908036 hasLocation W42239080362 @default.
- W4223908036 hasOpenAccess W4223908036 @default.
- W4223908036 hasPrimaryLocation W42239080361 @default.
- W4223908036 hasRelatedWork W1988747615 @default.
- W4223908036 hasRelatedWork W2145454786 @default.
- W4223908036 hasRelatedWork W2376211306 @default.