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• W4223912263 abstract "Increasing evidence has indicated that circular RNAs (circRNAs) act as competing endogenous RNAs (ceRNAs) regulatory network to regulate the expression of target genes by sponging microRNAs (miRNAs), and therefore play an essential role in many neuropsychiatric disorders, including cocaine use disorder. However, the functional roles and regulatory mechanisms of circRNAs as ceRNAs in dorsolateral prefrontal cortex (dlPFC) of patients with cocaine use disorder remain to be determined. In this study, an expression profiling for dlPFC in 19 patients with cocaine use disorder and 17 controls from Gene Expression Omnibus datasets was used for the differentially expressed circRNAs analysis and the differentially expressed mRNAs analysis. Several tools were used to predict the miRNAs targeted by the circRNAs and the miRNAs targeted mRNAs, which then overlapped with the cocaine-associated differentially expressed mRNAs to determine the functional roles of circRNAs. Functional analysis for the obtained mRNAs was performed via Gene Ontology (GO) in Metascape database. Integrated bioinformatics analysis was conducted to further characterize the circRNA–miRNA–mRNA regulatory network and identify the functions of distinct circRNAs. We found a total of 41 differentially expressed circRNAs, and 98 miRNAs were targeted by these circRNAs. The overlapped mRNAs targeted by the miRNAs and the differentially expressed mRNAs constructed a circRNA–miRNA–mRNA regulation network including 24 circRNAs, 43 miRNAs, and 82 mRNAs in the dlPFC of patients with cocaine use disorder. Functional analysis indicated the regulation network mainly participated in cell response-related, receptor signaling-related, protein modification-related and axonogenesis-related pathways, which might be involved with cocaine use disorder. Additionally, we determined four hub genes ( HSP90AA1 , HSPA1B , YWHAG , and RAB8A ) from the protein–protein interaction network and constructed a circRNA–miRNA-hub gene subnetwork based on the four hub genes. In conclusion, our findings provide a deeper understanding of the circRNAs-related ceRNAs regulatory mechanisms in the pathogenesis of cocaine use disorder." @default.
• W4223912263 created "2022-04-19" @default.
• W4223912263 creator A5005240419 @default.
• W4223912263 creator A5008347263 @default.
• W4223912263 creator A5019840354 @default.
• W4223912263 creator A5030426436 @default.
• W4223912263 creator A5035612207 @default.
• W4223912263 creator A5061402622 @default.
• W4223912263 date "2022-04-14" @default.
• W4223912263 modified "2023-10-09" @default.
• W4223912263 title "Identification of Functional CircRNA–miRNA–mRNA Regulatory Network in Dorsolateral Prefrontal Cortex Neurons of Patients With Cocaine Use Disorder" @default.
• W4223912263 cites W1601347600 @default.
• W4223912263 cites W1807334039 @default.
• W4223912263 cites W1966411071 @default.
• W4223912263 cites W1967064280 @default.
• W4223912263 cites W1971701977 @default.
• W4223912263 cites W1976070593 @default.
• W4223912263 cites W1991082489 @default.
• W4223912263 cites W1995082021 @default.
• W4223912263 cites W2004492484 @default.
• W4223912263 cites W2012852001 @default.
• W4223912263 cites W2013152806 @default.
• W4223912263 cites W2013536737 @default.
• W4223912263 cites W2021990305 @default.
• W4223912263 cites W2036897871 @default.
• W4223912263 cites W2039160638 @default.
• W4223912263 cites W2055920203 @default.
• W4223912263 cites W2058835062 @default.
• W4223912263 cites W2059965149 @default.
• W4223912263 cites W2060324739 @default.
• W4223912263 cites W2064165694 @default.
• W4223912263 cites W2065335807 @default.
• W4223912263 cites W2067005683 @default.
• W4223912263 cites W2072967696 @default.
• W4223912263 cites W2075527287 @default.
• W4223912263 cites W2079279420 @default.
• W4223912263 cites W2079645560 @default.
• W4223912263 cites W2079781983 @default.
• W4223912263 cites W2082141946 @default.
• W4223912263 cites W2091200481 @default.
• W4223912263 cites W2092435552 @default.
• W4223912263 cites W2103912979 @default.
• W4223912263 cites W2109577325 @default.
• W4223912263 cites W2109923675 @default.
• W4223912263 cites W2114104545 @default.
• W4223912263 cites W2115662330 @default.
• W4223912263 cites W2134629862 @default.
• W4223912263 cites W2139590804 @default.
• W4223912263 cites W2140600148 @default.
• W4223912263 cites W2159675211 @default.
• W4223912263 cites W2170551349 @default.
• W4223912263 cites W2171398108 @default.
• W4223912263 cites W2189323543 @default.
• W4223912263 cites W2266356262 @default.
• W4223912263 cites W2268827448 @default.
• W4223912263 cites W2285247593 @default.
• W4223912263 cites W2290820108 @default.
• W4223912263 cites W2299610769 @default.
• W4223912263 cites W2336528486 @default.
• W4223912263 cites W2401548643 @default.
• W4223912263 cites W2418027953 @default.
• W4223912263 cites W2460780103 @default.
• W4223912263 cites W2474303280 @default.
• W4223912263 cites W2511152819 @default.
• W4223912263 cites W2531297636 @default.
• W4223912263 cites W2537623931 @default.
• W4223912263 cites W2559904677 @default.
• W4223912263 cites W2587893207 @default.
• W4223912263 cites W2599812844 @default.
• W4223912263 cites W2600581473 @default.
• W4223912263 cites W2600842080 @default.
• W4223912263 cites W2601436215 @default.
• W4223912263 cites W2623552909 @default.
• W4223912263 cites W2736161898 @default.
• W4223912263 cites W2743353724 @default.
• W4223912263 cites W2744268790 @default.
• W4223912263 cites W2782518874 @default.
• W4223912263 cites W2791954023 @default.
• W4223912263 cites W2883062882 @default.
• W4223912263 cites W2891487738 @default.
• W4223912263 cites W2896194715 @default.
• W4223912263 cites W2899654445 @default.
• W4223912263 cites W2903734029 @default.
• W4223912263 cites W2913221496 @default.
• W4223912263 cites W2915433652 @default.
• W4223912263 cites W2916709262 @default.
• W4223912263 cites W2917858317 @default.
• W4223912263 cites W2923052285 @default.
• W4223912263 cites W2928665623 @default.
• W4223912263 cites W2931032935 @default.
• W4223912263 cites W2946035471 @default.
• W4223912263 cites W2947016784 @default.
• W4223912263 cites W2950451976 @default.
• W4223912263 cites W2950764390 @default.
• W4223912263 cites W2951344785 @default.
• W4223912263 cites W2955011788 @default.
• W4223912263 cites W2969952861 @default.
• W4223912263 cites W2970358232 @default.
• W4223912263 cites W2972625781 @default.
• W4223912263 cites W2999542134 @default.

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