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- W4223914374 abstract "Macropinocytosis is a type of endocytosis accompanied by actin rearrangement-driven membrane deformation, such as lamellipodia formation and membrane ruffling, followed by the formation of large vesicles, macropinosomes. Ras-transformed cancer cells efficiently acquire exogenous amino acids for their survival through macropinocytosis. Thus, inhibition of macropinocytosis is a promising strategy for cancer therapy. To date, few specific agents that inhibit macropinocytosis have been developed. Here, focusing on the mechanosensitive ion channel Piezo1, we found that Yoda1, a Piezo1 agonist, potently inhibits macropinocytosis induced by epidermal growth factor (EGF). The inhibition of ruffle formation by Yoda1 was dependent on the extracellular Ca2+ influx through Piezo1 and on the activation of the calcium-activated potassium channel KCa3.1. This suggests that Ca2+ ions can regulate EGF-stimulated macropinocytosis. We propose the potential for macropinocytosis inhibition through the regulation of a mechanosensitive channel activity using chemical tools." @default.
- W4223914374 created "2022-04-19" @default.
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- W4223914374 date "2022-04-15" @default.
- W4223914374 modified "2023-10-13" @default.
- W4223914374 title "Piezo1 activation using Yoda1 inhibits macropinocytosis in A431 human epidermoid carcinoma cells" @default.
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- W4223914374 doi "https://doi.org/10.1038/s41598-022-10153-8" @default.
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