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• W4223916790 startingPage "119211" @default.
• W4223916790 abstract "We demonstrate a data-driven approach for calculating a causal connectome of directed connectivity from resting-state fMRI data using a greedy adjacency search and pairwise non-Gaussian edge orientations. We used this approach to construct n = 442 causal connectomes. These connectomes were very sparse in comparison to typical Pearson correlation-based graphs (roughly 2.25% edge density) yet were fully connected in nearly all cases. Prominent highly connected hubs of the causal connectome were situated in attentional (dorsal attention) and executive (frontoparietal and cingulo-opercular) networks. These hub networks had distinctly different connectivity profiles: attentional networks shared incoming connections with sensory regions and outgoing connections with higher cognitive networks, while executive networks primarily connected to other higher cognitive networks and had a high degree of bidirected connectivity. Virtual lesion analyses accentuated these findings, demonstrating that attentional and executive hub networks are points of critical vulnerability in the human causal connectome. These data highlight the central role of attention and executive control networks in the human cortical connectome and set the stage for future applications of data-driven causal connectivity analysis in psychiatry." @default.
• W4223916790 created "2022-04-19" @default.
• W4223916790 creator A5023398276 @default.
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• W4223916790 creator A5069686854 @default.
• W4223916790 creator A5091663573 @default.
• W4223916790 creator A5091753355 @default.
• W4223916790 date "2022-07-01" @default.
• W4223916790 modified "2023-10-18" @default.
• W4223916790 title "The resting-state causal human connectome is characterized by hub connectivity of executive and attentional networks" @default.
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