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• W4223922647 abstract "The coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has been affecting the world since January 2020 and has caused millions of deaths. To gain a better insight into molecular changes underlying the COVID-19 disease, we investigated here the N -glycosylation of three immunoglobulin G (IgG) fractions isolated from plasma of 35 severe COVID-19 patients, namely total IgG 1 , total IgG 2 , and anti-Spike IgG, by means of MALDI-TOF-MS. All analyses were performed at the glycopeptide level to assure subclass- and site-specific information. For each COVID-19 patient, the analyses included three blood withdrawals at different time-points of hospitalization, which allowed profiling longitudinal alterations in IgG glycosylation. The COVID-19 patients presented altered IgG N -glycosylation profiles in all investigated IgG fractions. The most pronounced COVID-19-related changes were observed in the glycosylation profiles of antigen-specific anti-Spike IgG 1 . Anti-Spike IgG 1 fucosylation and galactosylation showed the strongest variation during the disease course, with the difference in anti-Spike IgG 1 fucosylation being significantly correlated with patients’ age. Decreases in anti-Spike IgG 1 galactosylation and sialylation in the course of the disease were found to be significantly correlated with the difference in anti-Spike IgG plasma concentration. The present findings suggest that patients’ age and anti-S IgG abundance might influence IgG N -glycosylation alterations occurring in COVID-19." @default.
• W4223922647 created "2022-04-19" @default.
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• W4223922647 date "2022-04-15" @default.
• W4223922647 modified "2023-10-09" @default.
• W4223922647 title "Coronavirus Disease 2019-Related Alterations of Total and Anti-Spike IgG Glycosylation in Relation to Age and Anti-Spike IgG Titer" @default.
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• W4223922647 doi "https://doi.org/10.3389/fmicb.2022.775186" @default.
• W4223922647 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35495660" @default.
• W4223922647 hasPublicationYear "2022" @default.
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