Matches in SemOpenAlex for { <https://semopenalex.org/work/W4223939026> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W4223939026 abstract "The cerebral cortex is responsible for higher cognitive functions. Its correct development depends on coordinated asymmetric division cycles by polarized radial glial progenitor cells. Mitotic defects in neuronal stem cells are linked to the aetiology of microcephaly, but the underlying mechanisms remain incompletely understood. Here we describe a novel role of the membrane deforming cytoskeletal regulator protein Abba (MTSS1L/MTSS2) in cortical development. Loss of Abba in the developing brain resulted in radial glia proliferation arrest, disorganized radial fibers and abnormal migration of neuronal progenitors. During cell division, Abba localized to the cleavage furrow where it recruited the scaffolding protein Nedd9 and positively regulated RhoA activity. Importantly, we identified a human variant Abba (R671W) in a patient with microcephaly and intellectual disability. Ectopic expression of this mutant protein in mice phenocopied Abba knockdown. Taken together, these data provide novel mechanistic insight into human microcephaly and cortical development by identifying ABBA as a novel regulator of faithful mitotic progression of neuronal progenitor cells." @default.
- W4223939026 created "2022-04-19" @default.
- W4223939026 creator A5002109405 @default.
- W4223939026 creator A5013579145 @default.
- W4223939026 creator A5021192161 @default.
- W4223939026 creator A5029677862 @default.
- W4223939026 creator A5030914122 @default.
- W4223939026 creator A5034136713 @default.
- W4223939026 creator A5055477594 @default.
- W4223939026 creator A5061846956 @default.
- W4223939026 creator A5068806587 @default.
- W4223939026 creator A5084227305 @default.
- W4223939026 creator A5089901203 @default.
- W4223939026 date "2022-04-04" @default.
- W4223939026 modified "2023-10-16" @default.
- W4223939026 title "Identification of novel microcephaly-linked protein ABBA that mediates cortical progenitor cell division and corticogenesis through NEDD9-RhoA" @default.
- W4223939026 doi "https://doi.org/10.1101/2022.03.28.22272122" @default.
- W4223939026 hasPublicationYear "2022" @default.
- W4223939026 type Work @default.
- W4223939026 citedByCount "0" @default.
- W4223939026 crossrefType "posted-content" @default.
- W4223939026 hasAuthorship W4223939026A5002109405 @default.
- W4223939026 hasAuthorship W4223939026A5013579145 @default.
- W4223939026 hasAuthorship W4223939026A5021192161 @default.
- W4223939026 hasAuthorship W4223939026A5029677862 @default.
- W4223939026 hasAuthorship W4223939026A5030914122 @default.
- W4223939026 hasAuthorship W4223939026A5034136713 @default.
- W4223939026 hasAuthorship W4223939026A5055477594 @default.
- W4223939026 hasAuthorship W4223939026A5061846956 @default.
- W4223939026 hasAuthorship W4223939026A5068806587 @default.
- W4223939026 hasAuthorship W4223939026A5084227305 @default.
- W4223939026 hasAuthorship W4223939026A5089901203 @default.
- W4223939026 hasBestOaLocation W42239390261 @default.
- W4223939026 hasConcept C104317684 @default.
- W4223939026 hasConcept C108619961 @default.
- W4223939026 hasConcept C136834591 @default.
- W4223939026 hasConcept C1491633281 @default.
- W4223939026 hasConcept C15729860 @default.
- W4223939026 hasConcept C201750760 @default.
- W4223939026 hasConcept C2776395126 @default.
- W4223939026 hasConcept C2777093181 @default.
- W4223939026 hasConcept C28328180 @default.
- W4223939026 hasConcept C54355233 @default.
- W4223939026 hasConcept C62478195 @default.
- W4223939026 hasConcept C6929976 @default.
- W4223939026 hasConcept C81885089 @default.
- W4223939026 hasConcept C85813293 @default.
- W4223939026 hasConcept C86803240 @default.
- W4223939026 hasConcept C93304396 @default.
- W4223939026 hasConcept C95444343 @default.
- W4223939026 hasConcept C97037327 @default.
- W4223939026 hasConceptScore W4223939026C104317684 @default.
- W4223939026 hasConceptScore W4223939026C108619961 @default.
- W4223939026 hasConceptScore W4223939026C136834591 @default.
- W4223939026 hasConceptScore W4223939026C1491633281 @default.
- W4223939026 hasConceptScore W4223939026C15729860 @default.
- W4223939026 hasConceptScore W4223939026C201750760 @default.
- W4223939026 hasConceptScore W4223939026C2776395126 @default.
- W4223939026 hasConceptScore W4223939026C2777093181 @default.
- W4223939026 hasConceptScore W4223939026C28328180 @default.
- W4223939026 hasConceptScore W4223939026C54355233 @default.
- W4223939026 hasConceptScore W4223939026C62478195 @default.
- W4223939026 hasConceptScore W4223939026C6929976 @default.
- W4223939026 hasConceptScore W4223939026C81885089 @default.
- W4223939026 hasConceptScore W4223939026C85813293 @default.
- W4223939026 hasConceptScore W4223939026C86803240 @default.
- W4223939026 hasConceptScore W4223939026C93304396 @default.
- W4223939026 hasConceptScore W4223939026C95444343 @default.
- W4223939026 hasConceptScore W4223939026C97037327 @default.
- W4223939026 hasLocation W42239390261 @default.
- W4223939026 hasOpenAccess W4223939026 @default.
- W4223939026 hasPrimaryLocation W42239390261 @default.
- W4223939026 hasRelatedWork W1978306051 @default.
- W4223939026 hasRelatedWork W1982662535 @default.
- W4223939026 hasRelatedWork W2078275670 @default.
- W4223939026 hasRelatedWork W2157794983 @default.
- W4223939026 hasRelatedWork W2158546099 @default.
- W4223939026 hasRelatedWork W2300366807 @default.
- W4223939026 hasRelatedWork W2594271141 @default.
- W4223939026 hasRelatedWork W2913146219 @default.
- W4223939026 hasRelatedWork W3193317966 @default.
- W4223939026 hasRelatedWork W4223939026 @default.
- W4223939026 isParatext "false" @default.
- W4223939026 isRetracted "false" @default.
- W4223939026 workType "article" @default.