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- W4223944281 abstract "Endogenous and exogenous tumor-related microRNAs (miRNAs) are considered promising tumor biomarkers and tumor therapeutic agents. In this work, we propose a miRNA self-responsive drug delivery system (miR-SR DDS), which enables the association between endogenous and exogenous miRNAs, so as to achieve a smart responsive and synergistic drug delivery. The miR-SR DDS consists of DNA-miRNA hybrids of let-7a and the complementary DNA of miR-155, which was packaged in exosomes. In response to the overexpressed miR-155 in breast cancer cells, the hybrids disintegrate and release let-7a and the complementary DNA of miR-155 to inhibit the expression of HMGA1 and relieve the inhibition of SOX1, respectively. Under the dual-targeted gene regulation, results show that the growth, migration and invasion of breast cancer cells can be synergistically inhibited through the Wnt/β-catenin signaling pathway. The concept and successful practice of the miR-SR DDS can be used as a reference for the development of miRNA drugs." @default.
- W4223944281 created "2022-04-19" @default.
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- W4223944281 date "2022-01-01" @default.
- W4223944281 modified "2023-10-16" @default.
- W4223944281 title "Smartly responsive DNA–miRNA hybrids packaged in exosomes for synergistic enhancement of cancer cell apoptosis" @default.
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- W4223944281 doi "https://doi.org/10.1039/d1nr08539e" @default.
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