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- W4223949368 endingPage "655.e7" @default.
- W4223949368 startingPage "639" @default.
- W4223949368 abstract "Adaptive CD4+ T helper cells and their innate counterparts, innate lymphoid cells, utilize an identical set of transcription factors (TFs) for their differentiation and functions. However, similarities and differences in the induction of these TFs in related lymphocytes are still elusive. Here, we show that T helper-1 (Th1) cells and natural killer (NK) cells displayed distinct epigenomes at the Tbx21 locus, which encodes T-bet, a critical TF for regulating type 1 immune responses. The initial induction of T-bet in NK precursors was dependent on the NK-specific DNase I hypersensitive site Tbx21-CNS-3, and the expression of the interleukin-18 (IL-18) receptor; IL-18 induced T-bet expression through the transcription factor RUNX3, which bound to Tbx21-CNS-3. By contrast, signal transducer and activator of transcription (STAT)-binding motifs within Tbx21-CNS-12 were critical for IL-12-induced T-bet expression during Th1 cell differentiation both in vitro and in vivo. Thus, type 1 innate and adaptive lymphocytes utilize distinct enhancer elements for their development and differentiation." @default.
- W4223949368 created "2022-04-19" @default.
- W4223949368 creator A5016487212 @default.
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- W4223949368 creator A5082435601 @default.
- W4223949368 date "2022-04-01" @default.
- W4223949368 modified "2023-10-16" @default.
- W4223949368 title "Differential regulation of transcription factor T-bet induction during NK cell development and T helper-1 cell differentiation" @default.
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