Matches in SemOpenAlex for { <https://semopenalex.org/work/W4223955204> ?p ?o ?g. }
- W4223955204 endingPage "8730" @default.
- W4223955204 startingPage "8719" @default.
- W4223955204 abstract "Poor water solubility and low bioavailability are considered as two main factors restricting therapeutic applications of natural polyphenols in relation to various disorders including amyloid-related diseases. Among various strategies developed to overcome these limitations, nanonization has attracted considerable attention. Herein, we compared the potency of bulk and nano forms of the polyphenolic fraction of pomegranate seed (PFPS) for modulating Hen Egg White Lysozyme (HEWL) amyloid fibril formation. Prepared PFPS nanosheets using direct oxidative pyrolysis were characterized by employing a range of spectroscopic and microscopic techniques. We found that the nano form can inhibit the assembly process and disintegrate preformed fibrils of HEWL much more effective than the bulk form of PFPS. Moreover, MTT-based cell viability and hemolysis assays showed the capacity of both bulk and nano forms of PFPS in attenuating HEWL amyloid fibril-induced toxicity, where the nano form was more effective. On the basis of thioflavin T results, a delay in the initiation of amyloid fibril assembly of HEWL appears to be the mechanism of action of PFPS nanosheets. We suggest that the improved efficiency of PFPS nanosheets in modulating the HEWL fibrillation process may be attributed to their increased surface area in accord with the surface-assistance model. Our results may present polyphenol-based nanosheets as a powerful approach for drug design against amyloid-related diseases." @default.
- W4223955204 created "2022-04-19" @default.
- W4223955204 creator A5056016354 @default.
- W4223955204 creator A5058917539 @default.
- W4223955204 creator A5063324502 @default.
- W4223955204 creator A5088955774 @default.
- W4223955204 date "2022-01-01" @default.
- W4223955204 modified "2023-09-26" @default.
- W4223955204 title "Pomegranate seed polyphenol-based nanosheets as an efficient inhibitor of amyloid fibril assembly and cytotoxicity of HEWL" @default.
- W4223955204 cites W1851265111 @default.
- W4223955204 cites W1887597376 @default.
- W4223955204 cites W1968964438 @default.
- W4223955204 cites W1975492392 @default.
- W4223955204 cites W1976632394 @default.
- W4223955204 cites W1978781288 @default.
- W4223955204 cites W1988927894 @default.
- W4223955204 cites W1991659188 @default.
- W4223955204 cites W2000610936 @default.
- W4223955204 cites W2000889074 @default.
- W4223955204 cites W2001099546 @default.
- W4223955204 cites W2010462701 @default.
- W4223955204 cites W2016513174 @default.
- W4223955204 cites W2020069228 @default.
- W4223955204 cites W2021488853 @default.
- W4223955204 cites W2027491539 @default.
- W4223955204 cites W2032255372 @default.
- W4223955204 cites W2038656308 @default.
- W4223955204 cites W2054992172 @default.
- W4223955204 cites W2056324592 @default.
- W4223955204 cites W2057910069 @default.
- W4223955204 cites W2064828983 @default.
- W4223955204 cites W2072639609 @default.
- W4223955204 cites W2084674813 @default.
- W4223955204 cites W2095028064 @default.
- W4223955204 cites W2099655698 @default.
- W4223955204 cites W2103629466 @default.
- W4223955204 cites W2107135234 @default.
- W4223955204 cites W2115808063 @default.
- W4223955204 cites W2128009612 @default.
- W4223955204 cites W2130916419 @default.
- W4223955204 cites W2138741130 @default.
- W4223955204 cites W2139549149 @default.
- W4223955204 cites W2152278845 @default.
- W4223955204 cites W2163196876 @default.
- W4223955204 cites W2163736026 @default.
- W4223955204 cites W2226753360 @default.
- W4223955204 cites W2499136986 @default.
- W4223955204 cites W2499684496 @default.
- W4223955204 cites W2515540488 @default.
- W4223955204 cites W2557067924 @default.
- W4223955204 cites W2597054437 @default.
- W4223955204 cites W2802994153 @default.
- W4223955204 cites W2894335672 @default.
- W4223955204 cites W2897644818 @default.
- W4223955204 cites W2901516737 @default.
- W4223955204 cites W2952223541 @default.
- W4223955204 cites W2998057409 @default.
- W4223955204 cites W3015599023 @default.
- W4223955204 cites W3015967600 @default.
- W4223955204 cites W3021540505 @default.
- W4223955204 cites W3035882682 @default.
- W4223955204 cites W3084190969 @default.
- W4223955204 cites W3091929513 @default.
- W4223955204 cites W3110564622 @default.
- W4223955204 cites W3136526409 @default.
- W4223955204 cites W3156282764 @default.
- W4223955204 cites W3203688532 @default.
- W4223955204 cites W960706032 @default.
- W4223955204 doi "https://doi.org/10.1039/d1ra05820g" @default.
- W4223955204 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35424834" @default.
- W4223955204 hasPublicationYear "2022" @default.
- W4223955204 type Work @default.
- W4223955204 citedByCount "1" @default.
- W4223955204 countsByYear W42239552042023 @default.
- W4223955204 crossrefType "journal-article" @default.
- W4223955204 hasAuthorship W4223955204A5056016354 @default.
- W4223955204 hasAuthorship W4223955204A5058917539 @default.
- W4223955204 hasAuthorship W4223955204A5063324502 @default.
- W4223955204 hasAuthorship W4223955204A5088955774 @default.
- W4223955204 hasBestOaLocation W42239552041 @default.
- W4223955204 hasConcept C109316439 @default.
- W4223955204 hasConcept C12554922 @default.
- W4223955204 hasConcept C142724271 @default.
- W4223955204 hasConcept C179104552 @default.
- W4223955204 hasConcept C181389837 @default.
- W4223955204 hasConcept C185592680 @default.
- W4223955204 hasConcept C202751555 @default.
- W4223955204 hasConcept C27523624 @default.
- W4223955204 hasConcept C2776966407 @default.
- W4223955204 hasConcept C2777633098 @default.
- W4223955204 hasConcept C2778004101 @default.
- W4223955204 hasConcept C2778896982 @default.
- W4223955204 hasConcept C2779134260 @default.
- W4223955204 hasConcept C2994168385 @default.
- W4223955204 hasConcept C3019447875 @default.
- W4223955204 hasConcept C502032728 @default.
- W4223955204 hasConcept C53227056 @default.
- W4223955204 hasConcept C55493867 @default.