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• W4223968052 abstract "Pancreatic ductal adenocarcinoma (PDAC) is notorious for high mortality due to limited options of appropriate chemotherapy drugs. Here we report that Aurora kinase-A expression is elevated in both human and mouse PDAC samples. MLN8237, an inhibitor of Aurora kinase-A, efficiently reduced the proliferation and motility of PDAC cells in vitro as well as tumor growth in orthotropic xenograft model and genetic pancreatic cancer animal models (p53/LSL/Pdx-Cre mice) in vivo. MLN8237 exhibited tumor inhibitory effect through inhibiting proliferation and migration, and inducing apoptosis and senescence. These results provide the molecular basis for a novel chemotherapy strategy for PDAC patients." @default.
• W4223968052 created "2022-04-19" @default.
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• W4223968052 date "2022-06-01" @default.
• W4223968052 modified "2023-10-18" @default.
• W4223968052 title "Aurora kinase a inhibitor MLN8237 suppresses pancreatic cancer growth" @default.
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• W4223968052 doi "https://doi.org/10.1016/j.pan.2022.03.019" @default.
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