Matches in SemOpenAlex for { <https://semopenalex.org/work/W4223969062> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W4223969062 endingPage "3328" @default.
- W4223969062 startingPage "3325" @default.
- W4223969062 abstract "Parabiosis is a well-established method to facilitate a shared blood supply between two conjoined animals. In particular, the pairing of mice of dissimilar ages, termed heterochronic parabiosis, has been used extensively for differentiating cell autonomous and non-autonomous mechanisms of aging. Analysis of heterochronic parabionts also has helped to identify individual circulating factors that may act as either pro- or anti-geronics. Heterochronic parabiosis also has proven to be a valuable experimental system to evaluate the effects of specific hallmarks of aging on the process of aging. For example, heterochronic parabiosis was used recently to examine whether cellular senescence was driven via cell autonomous and/or non-autonomous mechanisms. As anticipated, markers of cellular senescence were elevated in old isochronically-paired mice relative to young controls. However, compared to old isochronically paired mice, the senescent cell burden was reduced in multiple tissues of old parabionts joined with young mice. This suggests that the rejuvenation of cells and tissues in old mice by exposure to young blood could be mediated, in part, through suppression or immune clearance of senescent cells. Conversely, young heterochronic parabionts showed increased markers of cellular senescence, demonstrating that exposure to an old circulation is able to drive senescence through a cell non-autonomous mechanism(s), likely contributing to accelerated aging in the young mice. Thus, heterochronic parabiosis is still an important methodology that should continue to be leveraged for evaluating other hallmarks of aging and their mechanisms." @default.
- W4223969062 created "2022-04-19" @default.
- W4223969062 creator A5040467127 @default.
- W4223969062 creator A5075346656 @default.
- W4223969062 creator A5078174238 @default.
- W4223969062 date "2022-04-13" @default.
- W4223969062 modified "2023-10-18" @default.
- W4223969062 title "Heterochronic parabiosis: a valuable tool to investigate cellular senescence and other hallmarks of aging" @default.
- W4223969062 cites W1647542124 @default.
- W4223969062 cites W1832678746 @default.
- W4223969062 cites W1969905245 @default.
- W4223969062 cites W1978927200 @default.
- W4223969062 cites W2022487205 @default.
- W4223969062 cites W2046208657 @default.
- W4223969062 cites W2096575615 @default.
- W4223969062 cites W2124153237 @default.
- W4223969062 cites W2126525177 @default.
- W4223969062 cites W2264805444 @default.
- W4223969062 cites W2308474731 @default.
- W4223969062 cites W2330493936 @default.
- W4223969062 cites W2550166770 @default.
- W4223969062 cites W2589668141 @default.
- W4223969062 cites W2778607002 @default.
- W4223969062 cites W2988310131 @default.
- W4223969062 cites W3015526708 @default.
- W4223969062 cites W3106367108 @default.
- W4223969062 cites W3109061137 @default.
- W4223969062 cites W3213070933 @default.
- W4223969062 doi "https://doi.org/10.18632/aging.204015" @default.
- W4223969062 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35417855" @default.
- W4223969062 hasPublicationYear "2022" @default.
- W4223969062 type Work @default.
- W4223969062 citedByCount "0" @default.
- W4223969062 crossrefType "journal-article" @default.
- W4223969062 hasAuthorship W4223969062A5040467127 @default.
- W4223969062 hasAuthorship W4223969062A5075346656 @default.
- W4223969062 hasAuthorship W4223969062A5078174238 @default.
- W4223969062 hasBestOaLocation W42239690621 @default.
- W4223969062 hasConcept C169503297 @default.
- W4223969062 hasConcept C169760540 @default.
- W4223969062 hasConcept C203014093 @default.
- W4223969062 hasConcept C2777380497 @default.
- W4223969062 hasConcept C37291498 @default.
- W4223969062 hasConcept C522857546 @default.
- W4223969062 hasConcept C54355233 @default.
- W4223969062 hasConcept C86803240 @default.
- W4223969062 hasConcept C95444343 @default.
- W4223969062 hasConceptScore W4223969062C169503297 @default.
- W4223969062 hasConceptScore W4223969062C169760540 @default.
- W4223969062 hasConceptScore W4223969062C203014093 @default.
- W4223969062 hasConceptScore W4223969062C2777380497 @default.
- W4223969062 hasConceptScore W4223969062C37291498 @default.
- W4223969062 hasConceptScore W4223969062C522857546 @default.
- W4223969062 hasConceptScore W4223969062C54355233 @default.
- W4223969062 hasConceptScore W4223969062C86803240 @default.
- W4223969062 hasConceptScore W4223969062C95444343 @default.
- W4223969062 hasIssue "7" @default.
- W4223969062 hasLocation W42239690621 @default.
- W4223969062 hasLocation W42239690622 @default.
- W4223969062 hasLocation W42239690623 @default.
- W4223969062 hasOpenAccess W4223969062 @default.
- W4223969062 hasPrimaryLocation W42239690621 @default.
- W4223969062 hasRelatedWork W1818165799 @default.
- W4223969062 hasRelatedWork W1963930378 @default.
- W4223969062 hasRelatedWork W2550166770 @default.
- W4223969062 hasRelatedWork W3117261903 @default.
- W4223969062 hasRelatedWork W3159276004 @default.
- W4223969062 hasRelatedWork W4214948327 @default.
- W4223969062 hasRelatedWork W4223969062 @default.
- W4223969062 hasRelatedWork W4249231812 @default.
- W4223969062 hasRelatedWork W4309903404 @default.
- W4223969062 hasRelatedWork W4385331501 @default.
- W4223969062 hasVolume "14" @default.
- W4223969062 isParatext "false" @default.
- W4223969062 isRetracted "false" @default.
- W4223969062 workType "article" @default.