FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4223971377> ?p ?o ?g. }

• W4223971377 abstract "Systemic lupus erythematosus (SLE) is a complex autoimmune disease that affects several organs and causes variable clinical symptoms. Exploring new insights on genetic factors may help reveal SLE etiology and improve the survival of SLE patients. The current study is designed to identify key genes involved in SLE and develop potential diagnostic biomarkers for SLE in clinical practice. Expression data of all genes of SLE and control samples in GSE65391 and GSE72509 datasets were downloaded from the Gene Expression Omnibus (GEO) database. A total of 11 accurate differentially expressed genes (DEGs) were identified by the limma and RobustRankAggreg R package. All these genes were functionally associated with several immune-related biological processes and a single KEGG (Kyoto Encyclopedia of Genes and Genome) pathway of necroptosis. The PPI analysis showed that IFI44, IFI44L, EIF2AK2, IFIT3, IFITM3, ZBP1, TRIM22, PRIC285, XAF1, and PARP9 could interact with each other. In addition, the expression patterns of these DEGs were found to be consistent in GSE39088. Moreover, Receiver operating characteristic (ROC) curves analysis indicated that all these DEGs could serve as potential diagnostic biomarkers according to the area under the ROC curve (AUC) values. Furthermore, we constructed the transcription factor (TF)-diagnostic biomarker-microRNA (miRNA) network composed of 278 nodes and 405 edges, and a drug-diagnostic biomarker network consisting of 218 nodes and 459 edges. To investigate the relationship between diagnostic biomarkers and the immune system, we evaluated the immune infiltration landscape of SLE and control samples from GSE6539. Finally, using a variety of machine learning methods, IFI44 was determined to be the optimal diagnostic biomarker of SLE and then verified by quantitative real-time PCR (qRT-PCR) in an independent cohort. Our findings may benefit the diagnosis of patients with SLE and guide in developing novel targeted therapy in treating SLE patients." @default.
• W4223971377 created "2022-04-19" @default.
• W4223971377 creator A5013876571 @default.
• W4223971377 creator A5018063099 @default.
• W4223971377 creator A5035305864 @default.
• W4223971377 creator A5051226422 @default.
• W4223971377 creator A5062665642 @default.
• W4223971377 date "2022-04-14" @default.
• W4223971377 modified "2023-09-26" @default.
• W4223971377 title "Identification of Diagnostic Biomarkers in Systemic Lupus Erythematosus Based on Bioinformatics Analysis and Machine Learning" @default.
• W4223971377 cites W2005278031 @default.
• W4223971377 cites W2016765135 @default.
• W4223971377 cites W2032624312 @default.
• W4223971377 cites W2032684576 @default.
• W4223971377 cites W2035451872 @default.
• W4223971377 cites W2060218714 @default.
• W4223971377 cites W2078917883 @default.
• W4223971377 cites W2110793425 @default.
• W4223971377 cites W2111935795 @default.
• W4223971377 cites W2335122682 @default.
• W4223971377 cites W2590667571 @default.
• W4223971377 cites W2601428028 @default.
• W4223971377 cites W2753055890 @default.
• W4223971377 cites W2774234526 @default.
• W4223971377 cites W2791943550 @default.
• W4223971377 cites W2804257663 @default.
• W4223971377 cites W2805530493 @default.
• W4223971377 cites W2895024244 @default.
• W4223971377 cites W2944388007 @default.
• W4223971377 cites W2947507617 @default.
• W4223971377 cites W2970860829 @default.
• W4223971377 cites W2980845005 @default.
• W4223971377 cites W2983265730 @default.
• W4223971377 cites W2993314609 @default.
• W4223971377 cites W2994308589 @default.
• W4223971377 cites W2998343095 @default.
• W4223971377 cites W3010274200 @default.
• W4223971377 cites W3020577444 @default.
• W4223971377 cites W3025635158 @default.
• W4223971377 cites W3037439237 @default.
• W4223971377 cites W3089035187 @default.
• W4223971377 cites W3094471786 @default.
• W4223971377 cites W3103341147 @default.
• W4223971377 cites W3107031282 @default.
• W4223971377 cites W3108013492 @default.
• W4223971377 cites W3111410893 @default.
• W4223971377 cites W3120248484 @default.
• W4223971377 cites W3123168575 @default.
• W4223971377 cites W3133294514 @default.
• W4223971377 cites W3138337859 @default.
• W4223971377 cites W3155289645 @default.
• W4223971377 cites W3170414457 @default.
• W4223971377 cites W3176608959 @default.
• W4223971377 cites W3195693521 @default.
• W4223971377 cites W3209232513 @default.
• W4223971377 cites W4211146151 @default.
• W4223971377 doi "https://doi.org/10.3389/fgene.2022.865559" @default.
• W4223971377 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35495164" @default.
• W4223971377 hasPublicationYear "2022" @default.
• W4223971377 type Work @default.
• W4223971377 citedByCount "7" @default.
• W4223971377 countsByYear W42239713772022 @default.
• W4223971377 countsByYear W42239713772023 @default.
• W4223971377 crossrefType "journal-article" @default.
• W4223971377 hasAuthorship W4223971377A5013876571 @default.
• W4223971377 hasAuthorship W4223971377A5018063099 @default.
• W4223971377 hasAuthorship W4223971377A5035305864 @default.
• W4223971377 hasAuthorship W4223971377A5051226422 @default.
• W4223971377 hasAuthorship W4223971377A5062665642 @default.
• W4223971377 hasBestOaLocation W42239713771 @default.
• W4223971377 hasConcept C104317684 @default.
• W4223971377 hasConcept C116834253 @default.
• W4223971377 hasConcept C124535831 @default.
• W4223971377 hasConcept C126322002 @default.
• W4223971377 hasConcept C145059251 @default.
• W4223971377 hasConcept C150194340 @default.
• W4223971377 hasConcept C152724338 @default.
• W4223971377 hasConcept C162317418 @default.
• W4223971377 hasConcept C203014093 @default.
• W4223971377 hasConcept C2779075594 @default.
• W4223971377 hasConcept C2779134260 @default.
• W4223971377 hasConcept C2781197716 @default.
• W4223971377 hasConcept C3017616150 @default.
• W4223971377 hasConcept C46111723 @default.
• W4223971377 hasConcept C54355233 @default.
• W4223971377 hasConcept C58471807 @default.
• W4223971377 hasConcept C59822182 @default.
• W4223971377 hasConcept C60644358 @default.
• W4223971377 hasConcept C70721500 @default.
• W4223971377 hasConcept C71924100 @default.
• W4223971377 hasConcept C86803240 @default.
• W4223971377 hasConcept C8891405 @default.
• W4223971377 hasConceptScore W4223971377C104317684 @default.
• W4223971377 hasConceptScore W4223971377C116834253 @default.
• W4223971377 hasConceptScore W4223971377C124535831 @default.
• W4223971377 hasConceptScore W4223971377C126322002 @default.
• W4223971377 hasConceptScore W4223971377C145059251 @default.
• W4223971377 hasConceptScore W4223971377C150194340 @default.
• W4223971377 hasConceptScore W4223971377C152724338 @default.
• W4223971377 hasConceptScore W4223971377C162317418 @default.

• next