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- W4223972310 endingPage "212805" @default.
- W4223972310 startingPage "212805" @default.
- W4223972310 abstract "This study sought to prepare powder hemostats based on iota-carrageenan (ιC), xyloglucan (XYL), l-serine (SER), and tranexamic acid (TA). The powder form was chosen because it enables the hemostat to be used in wounds of any shape and depth. The powder hemostats showed irregular shapes and specific surface areas ranging from 34 to 46 m2/g. Increasing TA amount decreases the specific surface area, bulk density, water and blood absorption, and the antibacterial activities of the powder hemostats, but not the water retention ability. Conversely, in vitro biodegradation was positively impacted by increasing the TA content in the powder hemostats. In both the in vitro and in vivo tests, powder hemostats showed reduced bleeding time, significant adhesion of red blood cells, great hemocompatibility, moderate antioxidant activity, and high biocompatibility. These findings shed new light on designing powder hemostats with intrinsic antibacterial and antioxidant activity and excellent hemostatic performance." @default.
- W4223972310 created "2022-04-19" @default.
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- W4223972310 date "2022-06-01" @default.
- W4223972310 modified "2023-10-18" @default.
- W4223972310 title "Iota-carrageenan/xyloglucan/serine powders loaded with tranexamic acid for simultaneously hemostatic, antibacterial, and antioxidant performance" @default.
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- W4223972310 doi "https://doi.org/10.1016/j.bioadv.2022.212805" @default.
- W4223972310 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35929232" @default.
- W4223972310 hasPublicationYear "2022" @default.
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