Matches in SemOpenAlex for { <https://semopenalex.org/work/W4223981153> ?p ?o ?g. }
- W4223981153 abstract "ABSTRACT Brain and Muscle Arnt-like Protein 1 (BMAL1) is an essential component of the molecular clock underlying circadian rhythmicity. Recently, its function has also been associated with alterations in mood, and reward processing. We investigated the behavioural and neurobiological impact of Bmal1 gene deletion in mice, as well as how these alterations affect rewarding effects of cocaine. Additionally, key clock genes and components of the dopamine system were assessed in several brain areas. Our results evidence behavioural alterations in Bmal1-KO mice including changes in locomotor activity with impaired habituation to environments as well as short term memory and social recognition impairments. In addition, Bmal1-KO mice experienced reduced cocaine-induced sensitization and rewarding effects of cocaine as well as reduced cocaine-seeking behaviour. Furthermore, Bmal1 deletion influenced the expression of other clock-related genes in the mPFC and striatum as well as alterations in the expression of dopaminergic elements. Overall, the present article offers a novel and extensive characterization of Bmal1-KO animals. We suggest that reduced cocaine’s rewarding effects in these mutant mice might be related to Bmal1 role as an expression regulator of MAO and TH, two essential enzymes involved in dopamine metabolism." @default.
- W4223981153 created "2022-04-19" @default.
- W4223981153 creator A5002794866 @default.
- W4223981153 creator A5005979225 @default.
- W4223981153 creator A5028030156 @default.
- W4223981153 creator A5029010793 @default.
- W4223981153 creator A5049974667 @default.
- W4223981153 creator A5051608992 @default.
- W4223981153 creator A5052632566 @default.
- W4223981153 date "2022-04-05" @default.
- W4223981153 modified "2023-10-16" @default.
- W4223981153 title "<i>Bmal1</i>-knockout mice exhibit reduced cocaine-seeking behaviour and cognitive impairments" @default.
- W4223981153 cites W1998157722 @default.
- W4223981153 cites W1998352623 @default.
- W4223981153 cites W2003302378 @default.
- W4223981153 cites W2007140413 @default.
- W4223981153 cites W2012002548 @default.
- W4223981153 cites W2013743740 @default.
- W4223981153 cites W2014181599 @default.
- W4223981153 cites W2016646738 @default.
- W4223981153 cites W2018602168 @default.
- W4223981153 cites W2021569361 @default.
- W4223981153 cites W2040192661 @default.
- W4223981153 cites W2091612932 @default.
- W4223981153 cites W2094589586 @default.
- W4223981153 cites W2104290916 @default.
- W4223981153 cites W2108988707 @default.
- W4223981153 cites W2111274639 @default.
- W4223981153 cites W2120711366 @default.
- W4223981153 cites W2121847288 @default.
- W4223981153 cites W2123427001 @default.
- W4223981153 cites W2131227905 @default.
- W4223981153 cites W2141656485 @default.
- W4223981153 cites W2148780014 @default.
- W4223981153 cites W2151189356 @default.
- W4223981153 cites W2167027322 @default.
- W4223981153 cites W2168271199 @default.
- W4223981153 cites W2169922833 @default.
- W4223981153 cites W2237866086 @default.
- W4223981153 cites W2341411246 @default.
- W4223981153 cites W2346578806 @default.
- W4223981153 cites W2560775451 @default.
- W4223981153 cites W2587245829 @default.
- W4223981153 cites W2610875716 @default.
- W4223981153 cites W2769455380 @default.
- W4223981153 cites W2794385501 @default.
- W4223981153 cites W2805854894 @default.
- W4223981153 cites W2808964483 @default.
- W4223981153 cites W2891492746 @default.
- W4223981153 cites W2893705573 @default.
- W4223981153 cites W2914513283 @default.
- W4223981153 cites W2947638280 @default.
- W4223981153 cites W2986889609 @default.
- W4223981153 cites W2991440671 @default.
- W4223981153 cites W2995328089 @default.
- W4223981153 cites W2999876364 @default.
- W4223981153 cites W3048366096 @default.
- W4223981153 cites W3107116142 @default.
- W4223981153 cites W3124246488 @default.
- W4223981153 cites W3168649029 @default.
- W4223981153 cites W3182087698 @default.
- W4223981153 cites W4210973652 @default.
- W4223981153 cites W4237716260 @default.
- W4223981153 doi "https://doi.org/10.1101/2022.04.01.486740" @default.
- W4223981153 hasPublicationYear "2022" @default.
- W4223981153 type Work @default.
- W4223981153 citedByCount "0" @default.
- W4223981153 crossrefType "posted-content" @default.
- W4223981153 hasAuthorship W4223981153A5002794866 @default.
- W4223981153 hasAuthorship W4223981153A5005979225 @default.
- W4223981153 hasAuthorship W4223981153A5028030156 @default.
- W4223981153 hasAuthorship W4223981153A5029010793 @default.
- W4223981153 hasAuthorship W4223981153A5049974667 @default.
- W4223981153 hasAuthorship W4223981153A5051608992 @default.
- W4223981153 hasAuthorship W4223981153A5052632566 @default.
- W4223981153 hasBestOaLocation W42239811531 @default.
- W4223981153 hasConcept C104317684 @default.
- W4223981153 hasConcept C121446783 @default.
- W4223981153 hasConcept C137183658 @default.
- W4223981153 hasConcept C15744967 @default.
- W4223981153 hasConcept C169760540 @default.
- W4223981153 hasConcept C182704531 @default.
- W4223981153 hasConcept C2776217527 @default.
- W4223981153 hasConcept C2780062018 @default.
- W4223981153 hasConcept C35124327 @default.
- W4223981153 hasConcept C48856860 @default.
- W4223981153 hasConcept C50610925 @default.
- W4223981153 hasConcept C513476851 @default.
- W4223981153 hasConcept C54355233 @default.
- W4223981153 hasConcept C6929976 @default.
- W4223981153 hasConcept C86803240 @default.
- W4223981153 hasConceptScore W4223981153C104317684 @default.
- W4223981153 hasConceptScore W4223981153C121446783 @default.
- W4223981153 hasConceptScore W4223981153C137183658 @default.
- W4223981153 hasConceptScore W4223981153C15744967 @default.
- W4223981153 hasConceptScore W4223981153C169760540 @default.
- W4223981153 hasConceptScore W4223981153C182704531 @default.
- W4223981153 hasConceptScore W4223981153C2776217527 @default.
- W4223981153 hasConceptScore W4223981153C2780062018 @default.
- W4223981153 hasConceptScore W4223981153C35124327 @default.