Matches in SemOpenAlex for { <https://semopenalex.org/work/W4223982014> ?p ?o ?g. }
- W4223982014 abstract "In psoriatic skin, epidermal keratinocytes (KCs) undergo deregulated inflammatory response that leads to prolonged expression of inflammatory mediators as well as abnormal keratins. Due to immune and genetic factors, KCs get activated and cell balance gets disturbed. This activation is mainly due to deregulated inflammatory response. A vicious cycle of KC-immune response called KC activation cycle leads to psoriasis. In psoriatic skin, epidermal KCs undergo deregulated inflammatory response that leads to prolonged expression of inflammatory mediators as well as abnormal keratins. Methotrexate (MTX) an immunosuppressive agent has been used as a standard drug to treat severe psoriasis. Acanthosis and abnormal terminal differentiation was mainly due to the mutation in epidermal keratins. In turn, disease severity and relapsing of psoriasis are mainly due to the mutation of hyperproliferative keratins. These novel keratin mutations in psoriatic epidermis might be one of the causative factors for psoriasis. MTX strongly regulates the KC activation cycle by deregulated inflammatory markers and maintains normal keratin phenotype on hyperproliferating KC, thereby controlling acanthosis in psoriasis patients." @default.
- W4223982014 created "2022-04-19" @default.
- W4223982014 creator A5012436877 @default.
- W4223982014 creator A5014544648 @default.
- W4223982014 creator A5014817201 @default.
- W4223982014 creator A5033459720 @default.
- W4223982014 creator A5060007038 @default.
- W4223982014 creator A5063105777 @default.
- W4223982014 date "2022-08-31" @default.
- W4223982014 modified "2023-09-26" @default.
- W4223982014 title "Immunomodulatory Effect of Methotrexate Abruptly Controls Keratinocyte Activation in Psoriasis" @default.
- W4223982014 cites W118352842 @default.
- W4223982014 cites W1485133278 @default.
- W4223982014 cites W1495963743 @default.
- W4223982014 cites W1497080894 @default.
- W4223982014 cites W1505277713 @default.
- W4223982014 cites W151446319 @default.
- W4223982014 cites W1532206496 @default.
- W4223982014 cites W1534776554 @default.
- W4223982014 cites W1550569362 @default.
- W4223982014 cites W1556467835 @default.
- W4223982014 cites W1559385801 @default.
- W4223982014 cites W1560488482 @default.
- W4223982014 cites W1574615823 @default.
- W4223982014 cites W1576903429 @default.
- W4223982014 cites W1590318354 @default.
- W4223982014 cites W1594493125 @default.
- W4223982014 cites W1613432327 @default.
- W4223982014 cites W1882211948 @default.
- W4223982014 cites W1890532746 @default.
- W4223982014 cites W1895052772 @default.
- W4223982014 cites W1902683402 @default.
- W4223982014 cites W1908703453 @default.
- W4223982014 cites W1940477445 @default.
- W4223982014 cites W1963765331 @default.
- W4223982014 cites W1964219681 @default.
- W4223982014 cites W1964903324 @default.
- W4223982014 cites W1967660811 @default.
- W4223982014 cites W1970357219 @default.
- W4223982014 cites W1973326314 @default.
- W4223982014 cites W1973869185 @default.
- W4223982014 cites W1975039135 @default.
- W4223982014 cites W1975536411 @default.
- W4223982014 cites W1977648087 @default.
- W4223982014 cites W1979058179 @default.
- W4223982014 cites W1979488067 @default.
- W4223982014 cites W1983698057 @default.
- W4223982014 cites W1983851236 @default.
- W4223982014 cites W1984371682 @default.
- W4223982014 cites W1987015606 @default.
- W4223982014 cites W1987455407 @default.
- W4223982014 cites W1987784314 @default.
- W4223982014 cites W1989089757 @default.
- W4223982014 cites W1989416013 @default.
- W4223982014 cites W1990302146 @default.
- W4223982014 cites W1991048381 @default.
- W4223982014 cites W1991088949 @default.
- W4223982014 cites W1991540423 @default.
- W4223982014 cites W1994030928 @default.
- W4223982014 cites W1996008618 @default.
- W4223982014 cites W1996773947 @default.
- W4223982014 cites W1996921234 @default.
- W4223982014 cites W1998626766 @default.
- W4223982014 cites W1999139669 @default.
- W4223982014 cites W2000076767 @default.
- W4223982014 cites W2000961759 @default.
- W4223982014 cites W2002250623 @default.
- W4223982014 cites W2004439894 @default.
- W4223982014 cites W2004937659 @default.
- W4223982014 cites W2005359518 @default.
- W4223982014 cites W2005492777 @default.
- W4223982014 cites W2011842366 @default.
- W4223982014 cites W2013042452 @default.
- W4223982014 cites W2013748954 @default.
- W4223982014 cites W2013848946 @default.
- W4223982014 cites W2014820886 @default.
- W4223982014 cites W2016087238 @default.
- W4223982014 cites W2018115687 @default.
- W4223982014 cites W2019083095 @default.
- W4223982014 cites W2019720769 @default.
- W4223982014 cites W2019788712 @default.
- W4223982014 cites W2022199433 @default.
- W4223982014 cites W2023076934 @default.
- W4223982014 cites W2023929840 @default.
- W4223982014 cites W2024445459 @default.
- W4223982014 cites W2024514286 @default.
- W4223982014 cites W2027445122 @default.
- W4223982014 cites W2028969057 @default.
- W4223982014 cites W2029292942 @default.
- W4223982014 cites W2029819461 @default.
- W4223982014 cites W2029968450 @default.
- W4223982014 cites W2030627408 @default.
- W4223982014 cites W2032877369 @default.
- W4223982014 cites W2034654881 @default.
- W4223982014 cites W2037850728 @default.
- W4223982014 cites W2037933673 @default.
- W4223982014 cites W2038085058 @default.
- W4223982014 cites W2039396493 @default.
- W4223982014 cites W2040397446 @default.
- W4223982014 cites W2042117992 @default.