FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4223982954> ?p ?o ?g. }

• W4223982954 endingPage "e0010308" @default.
• W4223982954 startingPage "e0010308" @default.
• W4223982954 abstract "Malaria, blood-borne filarial worms and intestinal parasites are all endemic in Gabon. This geographical co-distribution leads to polyparasitism and, consequently, the possibility of immune-mediated interactions among different parasite species. Intestinal protozoa and helminths could modulate antimalarial immunity, for example, thereby potentially increasing or reducing susceptibility to malaria. The aim of the study was to compare the cytokine levels and cytokine ratios according to parasitic profiles of the population to determine the potential role of co-endemic parasites in the malaria susceptibility of populations. Blood and stool samples were collected during cross-sectional surveys in five provinces of Gabon. Parasitological diagnosis was performed to detect plasmodial parasites, Loa loa, Mansonella perstans, intestinal helminths (STHs) and protozoan parasites. Nested PCR was used to detect submicroscopic plasmodial infection in individuals with negative blood smears. A cytometric bead array was used to quantify interleukin (IL)-6, IL-10 and tumour necrosis factor (TNF)-α in the plasma of subjects with different parasitological profiles. Median IL-6 and IL-10 levels and the median IL-10/TNF-α ratio were all significantly higher among individuals with Plasmodium (P.) falciparum infection than among other participants (p<0.0001). The median TNF-α level and IL-10/IL-6 ratio were higher in subjects with STHs (p = 0.09) and P. falciparum-intestinal protozoa co-infection (p = 0.04), respectively. IL-6 (r = -0.37; P<0.01) and IL-10 (r = -0.37; P<0.01) levels and the IL-10/TNF-α ratio (r = -0.36; P<0.01) correlated negatively with age. Among children under five years old, the IL-10/TNF-α and IL-10/IL-6 ratios were higher in those with intestinal protozoan infections than in uninfected children. The IL-10/TNF-α ratio was also higher in children aged 5-15 years and in adults harbouring blood-borne filariae than in their control counterparts, whereas the IL-10/IL-6 ratio was lower in those aged 5-15 years with filariae and intestinal parasites but higher in adults with intestinal parasitic infections. Asymptomatic malaria is associated with a strong polarization towards a regulatory immune response, presenting high circulating levels of IL-10. P. falciparum/intestinal protozoa co-infections were associated with an enhanced IL-10 response. Immunity against malaria could differ according to age and carriage of other parasites. Helminths and intestinal protozoa can play a role in the high susceptibility to malaria currently observed in some areas of Gabon, but further investigations are necessary." @default.
• W4223982954 created "2022-04-19" @default.
• W4223982954 creator A5000564026 @default.
• W4223982954 creator A5015684718 @default.
• W4223982954 creator A5026907973 @default.
• W4223982954 creator A5041114636 @default.
• W4223982954 creator A5044099140 @default.
• W4223982954 creator A5045567311 @default.
• W4223982954 creator A5050214757 @default.
• W4223982954 creator A5061939226 @default.
• W4223982954 creator A5070635636 @default.
• W4223982954 creator A5077199504 @default.
• W4223982954 creator A5077273614 @default.
• W4223982954 date "2022-04-14" @default.
• W4223982954 modified "2023-10-17" @default.
• W4223982954 title "Circulating IL-6, IL-10, and TNF-alpha and IL-10/IL-6 and IL-10/TNF-alpha ratio profiles of polyparasitized individuals in rural and urban areas of gabon" @default.
• W4223982954 cites W1498494733 @default.
• W4223982954 cites W1538459559 @default.
• W4223982954 cites W1698313452 @default.
• W4223982954 cites W1804367091 @default.
• W4223982954 cites W1869362176 @default.
• W4223982954 cites W1970868036 @default.
• W4223982954 cites W1975738543 @default.
• W4223982954 cites W199510873 @default.
• W4223982954 cites W2004943814 @default.
• W4223982954 cites W2011724602 @default.
• W4223982954 cites W2032010009 @default.
• W4223982954 cites W2039502197 @default.
• W4223982954 cites W2046660752 @default.
• W4223982954 cites W2052203472 @default.
• W4223982954 cites W2053614206 @default.
• W4223982954 cites W2076169546 @default.
• W4223982954 cites W2076685189 @default.
• W4223982954 cites W2082342133 @default.
• W4223982954 cites W2089412223 @default.
• W4223982954 cites W2104239744 @default.
• W4223982954 cites W2105116084 @default.
• W4223982954 cites W2109292543 @default.
• W4223982954 cites W2110313894 @default.
• W4223982954 cites W2114512029 @default.
• W4223982954 cites W2115942810 @default.
• W4223982954 cites W2119700096 @default.
• W4223982954 cites W2120356605 @default.
• W4223982954 cites W2127379971 @default.
• W4223982954 cites W2131855490 @default.
• W4223982954 cites W2135606432 @default.
• W4223982954 cites W2139554478 @default.
• W4223982954 cites W2142395948 @default.
• W4223982954 cites W2145883324 @default.
• W4223982954 cites W2153642463 @default.
• W4223982954 cites W2165150658 @default.
• W4223982954 cites W2191654227 @default.
• W4223982954 cites W2257958774 @default.
• W4223982954 cites W2311703829 @default.
• W4223982954 cites W2312206683 @default.
• W4223982954 cites W2356183854 @default.
• W4223982954 cites W2410103562 @default.
• W4223982954 cites W2412508457 @default.
• W4223982954 cites W2414725590 @default.
• W4223982954 cites W2417120226 @default.
• W4223982954 cites W2507983450 @default.
• W4223982954 cites W2565506014 @default.
• W4223982954 cites W2582692751 @default.
• W4223982954 cites W2781102224 @default.
• W4223982954 cites W2786977234 @default.
• W4223982954 doi "https://doi.org/10.1371/journal.pntd.0010308" @default.
• W4223982954 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35421083" @default.
• W4223982954 hasPublicationYear "2022" @default.
• W4223982954 type Work @default.
• W4223982954 citedByCount "8" @default.
• W4223982954 countsByYear W42239829542022 @default.
• W4223982954 countsByYear W42239829542023 @default.
• W4223982954 crossrefType "journal-article" @default.
• W4223982954 hasAuthorship W4223982954A5000564026 @default.
• W4223982954 hasAuthorship W4223982954A5015684718 @default.
• W4223982954 hasAuthorship W4223982954A5026907973 @default.
• W4223982954 hasAuthorship W4223982954A5041114636 @default.
• W4223982954 hasAuthorship W4223982954A5044099140 @default.
• W4223982954 hasAuthorship W4223982954A5045567311 @default.
• W4223982954 hasAuthorship W4223982954A5050214757 @default.
• W4223982954 hasAuthorship W4223982954A5061939226 @default.
• W4223982954 hasAuthorship W4223982954A5070635636 @default.
• W4223982954 hasAuthorship W4223982954A5077199504 @default.
• W4223982954 hasAuthorship W4223982954A5077273614 @default.
• W4223982954 hasBestOaLocation W42239829541 @default.
• W4223982954 hasConcept C187316574 @default.
• W4223982954 hasConcept C203014093 @default.
• W4223982954 hasConcept C2778048844 @default.
• W4223982954 hasConcept C2778371730 @default.
• W4223982954 hasConcept C2778690821 @default.
• W4223982954 hasConcept C2908647359 @default.
• W4223982954 hasConcept C71924100 @default.
• W4223982954 hasConcept C86803240 @default.
• W4223982954 hasConcept C8891405 @default.
• W4223982954 hasConcept C99454951 @default.
• W4223982954 hasConceptScore W4223982954C187316574 @default.
• W4223982954 hasConceptScore W4223982954C203014093 @default.
• W4223982954 hasConceptScore W4223982954C2778048844 @default.

• next