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- W4223987570 endingPage "110333" @default.
- W4223987570 startingPage "110333" @default.
- W4223987570 abstract "G-protein coupled receptor (GPCR) kinases (GRKs) and β-arrestins play key roles in GPCR and non-GPCR cellular responses. In fact, GRKs and arrestins are involved in a plethora of pathways vital for physiological maintenance of inter- and intracellular communication. Here we review decades of research literature spanning from the discovery, identification of key structural elements, and findings supporting the diverse roles of these proteins in GPCR-mediated pathways. We then describe how GRK2 and β-arrestins partake in non-GPCR signaling and briefly summarize their involvement in various pathologies. We conclude by presenting gaps in knowledge and our prospective on the promising pharmacological potential in targeting these proteins and/or downstream signaling. Future research is warranted and paramount for untangling these novel and promising roles for GRK2 and arrestins in metabolism and disease progression." @default.
- W4223987570 created "2022-04-19" @default.
- W4223987570 creator A5034931929 @default.
- W4223987570 creator A5047490339 @default.
- W4223987570 creator A5066609936 @default.
- W4223987570 creator A5089318838 @default.
- W4223987570 date "2022-06-01" @default.
- W4223987570 modified "2023-09-23" @default.
- W4223987570 title "Double life: How GRK2 and β-arrestin signaling participate in diseases" @default.
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