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- W4223988049 abstract "Aim: The aim of this article is to characterize in detail the γδ T lymphocytes from an adult patient with primary cutaneous T-cell lymphoma of γδ subtype (γδ CTCL). Methods: Here this article reports trajectory mapping on high-resolution differentiation trajectories of γδ T lymphocytes digitally extracted from a scRNAseq dataset. Results: In the patch-to-plaque progression of CTCL, the TCRVγnon9 subset of γδ T cells differentiated from naive T cells (Tn) and central memory T cells (Tcm) to abundant effector memory T cells (Tem) while other cutaneous γδ T and CD8 T cells remained unchanged. Conclusions: This transcriptomic switch underlies the emergence of a CTCL-like progression of the TCRVγnon9 γδ T subtype and suggests new routes for treating these diseases." @default.
- W4223988049 created "2022-04-19" @default.
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- W4223988049 date "2022-04-15" @default.
- W4223988049 modified "2023-10-14" @default.
- W4223988049 title "Single-cell differentiation trajectories define early stages of a human cutaneous T-cell lymphoma" @default.
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- W4223988049 doi "https://doi.org/10.37349/ei.2022.00044" @default.
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