FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4223990468> ?p ?o ?g. }

• W4223990468 abstract "The purpose of the present trial was to determine the feasibility of the daily topical application of the piperidine nitroxide, MTS‑01, combined with chemoradiotherapy in the treatment of patients with anal carcinoma. The secondary study endpoints were the description of the effects of this agent on skin toxicity and rectal‑associated lymphoid tissue. The participants received radiotherapy concurrent with mitomycin‑C and 5‑fluorouracil for carcinoma of the anal canal. MTS‑01 was applied to the bilateral inguinal area and the gluteal cleft. Dermatologic and non‑dermatologic toxicity was graded throughout the treatment period. Circulating lymphocytes were serially collected for phenotyping. Rectal mucosal snag biopsies were collected at baseline and at 1 year of follow‑up. A total of 5 patients received topical MTS‑01. Adverse events attributed to MTS‑01 included asymptomatic grade 1 hypoglycemia and grade 1‑2 diarrhea. Dermatitis within untreated, radiated skin was not more severe than dermatitis in MTS‑01‑treated, unirradiated skin. Circulating CD4+ lymphocyte suppression was noted at >1 year following treatment in human immunodeficiency virus‑negative participants. CD4+ lymphocytes remained suppressed in the irradiated rectal mucosa at 1 year, whereas the CD8+ lymphocyte numbers recovered or increased. On the whole, the present study demonstrates that the MTS‑01 topical application was tolerable with minimal toxicity. Chemoradiation for anal cancer led to prolonged CD4+ lymphocytopenia in the circulation and gut mucosa." @default.
• W4223990468 created "2022-04-19" @default.
• W4223990468 creator A5013765512 @default.
• W4223990468 creator A5023611119 @default.
• W4223990468 creator A5028168099 @default.
• W4223990468 creator A5036663495 @default.
• W4223990468 creator A5042769205 @default.
• W4223990468 creator A5050211879 @default.
• W4223990468 creator A5072939048 @default.
• W4223990468 creator A5076213753 @default.
• W4223990468 creator A5084755258 @default.
• W4223990468 creator A5089780095 @default.
• W4223990468 date "2022-04-15" @default.
• W4223990468 modified "2023-10-18" @default.
• W4223990468 title "Pilot trial of topical MTS‑01 application to reduce dermatitis in patients receiving chemoradiotherapy for stage I‑III carcinoma of the anal canal" @default.
• W4223990468 cites W1974539949 @default.
• W4223990468 cites W1976743732 @default.
• W4223990468 cites W1984270070 @default.
• W4223990468 cites W2035228551 @default.
• W4223990468 cites W2042582442 @default.
• W4223990468 cites W2045804591 @default.
• W4223990468 cites W2046331938 @default.
• W4223990468 cites W2048765702 @default.
• W4223990468 cites W2055442814 @default.
• W4223990468 cites W2063345415 @default.
• W4223990468 cites W2073119484 @default.
• W4223990468 cites W2076341925 @default.
• W4223990468 cites W2098056848 @default.
• W4223990468 cites W2098480747 @default.
• W4223990468 cites W2100037725 @default.
• W4223990468 cites W2113138876 @default.
• W4223990468 cites W2127936550 @default.
• W4223990468 cites W2143865882 @default.
• W4223990468 cites W2171970710 @default.
• W4223990468 cites W2173283967 @default.
• W4223990468 cites W2214926248 @default.
• W4223990468 cites W2313644306 @default.
• W4223990468 cites W2320909684 @default.
• W4223990468 cites W2752659864 @default.
• W4223990468 cites W2769312395 @default.
• W4223990468 cites W2898340040 @default.
• W4223990468 cites W3110938402 @default.
• W4223990468 cites W3119005666 @default.
• W4223990468 cites W3124252419 @default.
• W4223990468 cites W3135227511 @default.
• W4223990468 cites W3136633297 @default.
• W4223990468 doi "https://doi.org/10.3892/ijo.2022.5358" @default.
• W4223990468 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35438186" @default.
• W4223990468 hasPublicationYear "2022" @default.
• W4223990468 type Work @default.
• W4223990468 citedByCount "1" @default.
• W4223990468 countsByYear W42239904682023 @default.
• W4223990468 crossrefType "journal-article" @default.
• W4223990468 hasAuthorship W4223990468A5013765512 @default.
• W4223990468 hasAuthorship W4223990468A5023611119 @default.
• W4223990468 hasAuthorship W4223990468A5028168099 @default.
• W4223990468 hasAuthorship W4223990468A5036663495 @default.
• W4223990468 hasAuthorship W4223990468A5042769205 @default.
• W4223990468 hasAuthorship W4223990468A5050211879 @default.
• W4223990468 hasAuthorship W4223990468A5072939048 @default.
• W4223990468 hasAuthorship W4223990468A5076213753 @default.
• W4223990468 hasAuthorship W4223990468A5084755258 @default.
• W4223990468 hasAuthorship W4223990468A5089780095 @default.
• W4223990468 hasBestOaLocation W42239904681 @default.
• W4223990468 hasConcept C121608353 @default.
• W4223990468 hasConcept C126322002 @default.
• W4223990468 hasConcept C141071460 @default.
• W4223990468 hasConcept C16005928 @default.
• W4223990468 hasConcept C2777546739 @default.
• W4223990468 hasConcept C2778496288 @default.
• W4223990468 hasConcept C2778570526 @default.
• W4223990468 hasConcept C2779840525 @default.
• W4223990468 hasConcept C2780035688 @default.
• W4223990468 hasConcept C2781074409 @default.
• W4223990468 hasConcept C2910643260 @default.
• W4223990468 hasConcept C29730261 @default.
• W4223990468 hasConcept C71924100 @default.
• W4223990468 hasConcept C90924648 @default.
• W4223990468 hasConceptScore W4223990468C121608353 @default.
• W4223990468 hasConceptScore W4223990468C126322002 @default.
• W4223990468 hasConceptScore W4223990468C141071460 @default.
• W4223990468 hasConceptScore W4223990468C16005928 @default.
• W4223990468 hasConceptScore W4223990468C2777546739 @default.
• W4223990468 hasConceptScore W4223990468C2778496288 @default.
• W4223990468 hasConceptScore W4223990468C2778570526 @default.
• W4223990468 hasConceptScore W4223990468C2779840525 @default.
• W4223990468 hasConceptScore W4223990468C2780035688 @default.
• W4223990468 hasConceptScore W4223990468C2781074409 @default.
• W4223990468 hasConceptScore W4223990468C2910643260 @default.
• W4223990468 hasConceptScore W4223990468C29730261 @default.
• W4223990468 hasConceptScore W4223990468C71924100 @default.
• W4223990468 hasConceptScore W4223990468C90924648 @default.
• W4223990468 hasIssue "6" @default.
• W4223990468 hasLocation W42239904681 @default.
• W4223990468 hasLocation W42239904682 @default.
• W4223990468 hasLocation W42239904683 @default.
• W4223990468 hasOpenAccess W4223990468 @default.
• W4223990468 hasPrimaryLocation W42239904681 @default.
• W4223990468 hasRelatedWork W1907241612 @default.
• W4223990468 hasRelatedWork W1995639223 @default.

• next