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• W4223995509 abstract "Accumulating evidence suggests that dysregulation of Chordin-like 1 (CHRDL1) is associated with malignant biological behaviors in multiple cancers. However, the exact function and molecular mechanism of CHRDL1 in oral squamous cell carcinoma (OSCC) remain unclear.The expression levels of CHRDL1 in OSCC tissues and CAL27 cells were determined by RT-qPCR. Immunohistochemical staining was applied to detect CHRDL1 protein expression in sample tissues from OSCC patients. Gain of function and knockdown by lentivirus were further used to examine the effects of CHRDL1 on cell proliferation, migration, invasion, and adhesion in OSCC. Tail vein injection of CAL27 cells with dysregulated CHRDL1 expression was further used to examine the effect of CHRDL1 on lung colonization. RNA sequencing was performed to explore the molecular mechanisms of CHRDL1 that underlie the progression of OSCC.CHRDL1 was significantly downregulated in OSCC tissues and CAL27 cells compared to controls. CHRDL1 knockdown enhanced migration, invasion, adhesion, and EMT, but not proliferation, in CAL27 cells. Overexpression of CHRDL1 had the opposite effects. Moreover, CHRDL1 was proven to inhibit tumor metastasis in vivo. Mechanistically, MAPK signaling pathway components, including ERK1/2, p38, and JNK, were found to regulate the malignant biological behaviors of CAL27 cells.Our results suggest that CHRDL1 has an inhibitory effect on OSCC metastasis via the MAPK signaling pathway, which provides a new possible potential therapeutic target against OSCC." @default.
• W4223995509 created "2022-04-19" @default.
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• W4223995509 date "2022-04-14" @default.
• W4223995509 modified "2023-10-16" @default.
• W4223995509 title "Chordin-Like 1 Regulates Epithelial-to-Mesenchymal Transition and Metastasis via the MAPK Signaling Pathway in Oral Squamous Cell Carcinoma" @default.
• W4223995509 cites W1545152283 @default.
• W4223995509 cites W1965684055 @default.
• W4223995509 cites W1967824335 @default.
• W4223995509 cites W1969526995 @default.
• W4223995509 cites W1973612882 @default.
• W4223995509 cites W1981765038 @default.
• W4223995509 cites W1986241711 @default.
• W4223995509 cites W1999748460 @default.
• W4223995509 cites W2001660827 @default.
• W4223995509 cites W2004718663 @default.
• W4223995509 cites W2008165339 @default.
• W4223995509 cites W2012729913 @default.
• W4223995509 cites W2016360721 @default.
• W4223995509 cites W2021881397 @default.
• W4223995509 cites W2027257123 @default.
• W4223995509 cites W2031940984 @default.
• W4223995509 cites W2033247490 @default.
• W4223995509 cites W2034431170 @default.
• W4223995509 cites W2037575576 @default.
• W4223995509 cites W2043103956 @default.
• W4223995509 cites W2062312459 @default.
• W4223995509 cites W2064949716 @default.
• W4223995509 cites W2067154774 @default.
• W4223995509 cites W2067631969 @default.
• W4223995509 cites W2071467611 @default.
• W4223995509 cites W2074941062 @default.
• W4223995509 cites W2088460216 @default.
• W4223995509 cites W2090818324 @default.
• W4223995509 cites W2097642044 @default.
• W4223995509 cites W2115582154 @default.
• W4223995509 cites W2120522790 @default.
• W4223995509 cites W2135938911 @default.
• W4223995509 cites W2151989714 @default.
• W4223995509 cites W2154241060 @default.
• W4223995509 cites W2160751536 @default.
• W4223995509 cites W2163809391 @default.
• W4223995509 cites W2195532968 @default.
• W4223995509 cites W2287472947 @default.
• W4223995509 cites W2345509148 @default.
• W4223995509 cites W2345526647 @default.
• W4223995509 cites W2346530374 @default.
• W4223995509 cites W2495175348 @default.
• W4223995509 cites W2569044346 @default.
• W4223995509 cites W2590499708 @default.
• W4223995509 cites W2600111905 @default.
• W4223995509 cites W2604326916 @default.
• W4223995509 cites W2607129810 @default.
• W4223995509 cites W2768378655 @default.
• W4223995509 cites W2789892633 @default.
• W4223995509 cites W2807021851 @default.
• W4223995509 cites W2905542410 @default.
• W4223995509 cites W2916992870 @default.
• W4223995509 cites W2925248542 @default.
• W4223995509 cites W2934848272 @default.
• W4223995509 cites W2944720621 @default.
• W4223995509 cites W2949398488 @default.
• W4223995509 cites W2954194137 @default.
• W4223995509 cites W2963473092 @default.
• W4223995509 cites W2991367220 @default.
• W4223995509 cites W3014696431 @default.
• W4223995509 cites W3045157556 @default.
• W4223995509 cites W3081196080 @default.
• W4223995509 cites W3083696664 @default.
• W4223995509 cites W3123610678 @default.
• W4223995509 cites W3128646645 @default.
• W4223995509 cites W3132103142 @default.
• W4223995509 cites W3138022145 @default.
• W4223995509 cites W3158974490 @default.
• W4223995509 cites W3163186816 @default.
• W4223995509 cites W3173801647 @default.
• W4223995509 cites W3194413840 @default.
• W4223995509 cites W3217280640 @default.
• W4223995509 cites W4206772208 @default.
• W4223995509 cites W4210298886 @default.
• W4223995509 cites W4232351203 @default.
• W4223995509 cites W835417322 @default.
• W4223995509 cites W896395170 @default.
• W4223995509 doi "https://doi.org/10.3389/fonc.2022.862751" @default.
• W4223995509 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35494000" @default.
• W4223995509 hasPublicationYear "2022" @default.

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