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- W4223997148 abstract "Experience-dependent changes in behavior are mediated by long-term functional modifications in brain circuits. Activity-dependent plasticity of synaptic input is a major underlying cellular process. Although we have a detailed understanding of synaptic and dendritic plasticity in vitro, little is known about the functional and plastic properties of active dendrites in behaving animals. Using deep brain two-photon Ca2+ imaging, we investigated how sensory responses in amygdala principal neurons develop upon classical fear conditioning, a form of associative learning. Fear conditioning induced differential plasticity in dendrites and somas regulated by compartment-specific inhibition. Our results indicate that learning-induced plasticity can be uncoupled between soma and dendrites, reflecting distinct synaptic and microcircuit-level mechanisms that increase the computational capacity of amygdala circuits." @default.
- W4223997148 created "2022-04-19" @default.
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- W4223997148 date "2022-04-15" @default.
- W4223997148 modified "2023-10-10" @default.
- W4223997148 title "Compartmentalized dendritic plasticity during associative learning" @default.
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- W4223997148 doi "https://doi.org/10.1126/science.abf7052" @default.
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