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- W4224003362 abstract "Higher physical activity levels are associated with reduced cognitive decline among older adults; however, current understanding of underlying brain mechanisms is limited. This cross-sectional study investigated the relationship between actigraphy-estimated total volume of physical activity (TVPA) and magnetic resonance imaging (MRI) measures of white matter hyperintensities (WMH), and functional and structural brain connectivity, measured by resting-state functional MRI and diffusion tensor imaging. Study participants (N = 156, mean age = 71 years) included 136 with normal cognition and 20 with Mild Cognitive Impairment. Higher TVPA was associated with greater functional connectivity within the default-mode network and greater network modularity (a measure of network specialization), as well as with greater anisotropy and lower radial diffusion in white matter, suggesting better structural connectivity. These associations with functional and structural connectivity were independent of one another and independent of the level of vascular risk, APOE-ε4 status, cognitive reserve, and WMH volume, which were not associated with TVPA. Findings suggest that physical activity is beneficial for brain connectivity among older individuals with varying levels of risk for cognitive decline." @default.
- W4224003362 created "2022-04-19" @default.
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- W4224003362 date "2022-08-01" @default.
- W4224003362 modified "2023-09-26" @default.
- W4224003362 title "Actigraphy-estimated physical activity is associated with functional and structural brain connectivity among older adults" @default.
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- W4224003362 doi "https://doi.org/10.1016/j.neurobiolaging.2022.04.006" @default.
- W4224003362 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35551019" @default.
- W4224003362 hasPublicationYear "2022" @default.
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