Matches in SemOpenAlex for { <https://semopenalex.org/work/W4224010140> ?p ?o ?g. }
- W4224010140 endingPage "101916" @default.
- W4224010140 startingPage "101916" @default.
- W4224010140 abstract "Activated Cdc42-associated kinase (ACK) is an oncogenic nonreceptor tyrosine kinase associated with poor prognosis in several human cancers. ACK promotes proliferation, in part by contributing to the activation of Akt, the major effector of class 1A phosphoinositide 3-kinases (PI3Ks), which transduce signals via membrane phosphoinositol lipids. We now show that ACK also interacts with other key components of class 1A PI3K signaling, the PI3K regulatory subunits. We demonstrate ACK binds to all five PI3K regulatory subunit isoforms and directly phosphorylates p85α, p85β, p50α, and p55α on Tyr607 (or analogous residues). We found that phosphorylation of p85β promotes cell proliferation in HEK293T cells. We demonstrate that ACK interacts with p85α exclusively in nuclear-enriched cell fractions, where p85α phosphorylated at Tyr607 (pTyr607) also resides, and identify an interaction between pTyr607 and the N-terminal SH2 domain that supports dimerization of the regulatory subunits. We infer from this that ACK targets p110-independent p85 and further postulate that these regulatory subunit dimers undertake novel nuclear functions underpinning ACK activity. We conclude that these dimers represent a previously undescribed mode of regulation for the class1A PI3K regulatory subunits and potentially reveal additional avenues for therapeutic intervention." @default.
- W4224010140 created "2022-04-19" @default.
- W4224010140 creator A5019262606 @default.
- W4224010140 creator A5021231138 @default.
- W4224010140 creator A5024632241 @default.
- W4224010140 creator A5024695099 @default.
- W4224010140 creator A5024943442 @default.
- W4224010140 creator A5025868708 @default.
- W4224010140 creator A5027021311 @default.
- W4224010140 creator A5031519165 @default.
- W4224010140 creator A5043387899 @default.
- W4224010140 creator A5049217507 @default.
- W4224010140 creator A5058325442 @default.
- W4224010140 date "2022-06-01" @default.
- W4224010140 modified "2023-10-15" @default.
- W4224010140 title "Assembly of nuclear dimers of PI3K regulatory subunits is regulated by the Cdc42-activated tyrosine kinase ACK" @default.
- W4224010140 cites W1526250277 @default.
- W4224010140 cites W1551252878 @default.
- W4224010140 cites W1601620362 @default.
- W4224010140 cites W1947165807 @default.
- W4224010140 cites W1969292035 @default.
- W4224010140 cites W1983001241 @default.
- W4224010140 cites W1985225299 @default.
- W4224010140 cites W1986276126 @default.
- W4224010140 cites W1992477322 @default.
- W4224010140 cites W1994888440 @default.
- W4224010140 cites W2000965396 @default.
- W4224010140 cites W2001847316 @default.
- W4224010140 cites W2016398041 @default.
- W4224010140 cites W2020736452 @default.
- W4224010140 cites W2023568503 @default.
- W4224010140 cites W2029186861 @default.
- W4224010140 cites W2035145212 @default.
- W4224010140 cites W2039815737 @default.
- W4224010140 cites W2047425894 @default.
- W4224010140 cites W2048473455 @default.
- W4224010140 cites W2055013229 @default.
- W4224010140 cites W2061152791 @default.
- W4224010140 cites W2066586943 @default.
- W4224010140 cites W2081511916 @default.
- W4224010140 cites W2097312459 @default.
- W4224010140 cites W2097665491 @default.
- W4224010140 cites W2098922951 @default.
- W4224010140 cites W2104124358 @default.
- W4224010140 cites W2115826043 @default.
- W4224010140 cites W2129221351 @default.
- W4224010140 cites W2132448632 @default.
- W4224010140 cites W2135784953 @default.
- W4224010140 cites W2143327951 @default.
- W4224010140 cites W2154019529 @default.
- W4224010140 cites W2164443997 @default.
- W4224010140 cites W2270742048 @default.
- W4224010140 cites W2397963384 @default.
- W4224010140 cites W2559840336 @default.
- W4224010140 cites W2626401975 @default.
- W4224010140 cites W2900905486 @default.
- W4224010140 cites W2984955289 @default.
- W4224010140 cites W2992907960 @default.
- W4224010140 cites W3015964336 @default.
- W4224010140 cites W3042430614 @default.
- W4224010140 cites W3185197558 @default.
- W4224010140 cites W781001238 @default.
- W4224010140 doi "https://doi.org/10.1016/j.jbc.2022.101916" @default.
- W4224010140 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35429500" @default.
- W4224010140 hasPublicationYear "2022" @default.
- W4224010140 type Work @default.
- W4224010140 citedByCount "7" @default.
- W4224010140 countsByYear W42240101402022 @default.
- W4224010140 countsByYear W42240101402023 @default.
- W4224010140 crossrefType "journal-article" @default.
- W4224010140 hasAuthorship W4224010140A5019262606 @default.
- W4224010140 hasAuthorship W4224010140A5021231138 @default.
- W4224010140 hasAuthorship W4224010140A5024632241 @default.
- W4224010140 hasAuthorship W4224010140A5024695099 @default.
- W4224010140 hasAuthorship W4224010140A5024943442 @default.
- W4224010140 hasAuthorship W4224010140A5025868708 @default.
- W4224010140 hasAuthorship W4224010140A5027021311 @default.
- W4224010140 hasAuthorship W4224010140A5031519165 @default.
- W4224010140 hasAuthorship W4224010140A5043387899 @default.
- W4224010140 hasAuthorship W4224010140A5049217507 @default.
- W4224010140 hasAuthorship W4224010140A5058325442 @default.
- W4224010140 hasBestOaLocation W42240101401 @default.
- W4224010140 hasConcept C104292427 @default.
- W4224010140 hasConcept C104317684 @default.
- W4224010140 hasConcept C108636557 @default.
- W4224010140 hasConcept C11960822 @default.
- W4224010140 hasConcept C170493617 @default.
- W4224010140 hasConcept C174510640 @default.
- W4224010140 hasConcept C184235292 @default.
- W4224010140 hasConcept C185592680 @default.
- W4224010140 hasConcept C197153747 @default.
- W4224010140 hasConcept C2780040266 @default.
- W4224010140 hasConcept C2781322055 @default.
- W4224010140 hasConcept C42362537 @default.
- W4224010140 hasConcept C55493867 @default.
- W4224010140 hasConcept C62478195 @default.
- W4224010140 hasConcept C75217442 @default.
- W4224010140 hasConcept C86554907 @default.