Matches in SemOpenAlex for { <https://semopenalex.org/work/W4224012292> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W4224012292 endingPage "55" @default.
- W4224012292 startingPage "49" @default.
- W4224012292 abstract "In this study, an experimental protocol has been developed for comparing survival rates of mutant and wild-type zebrafish larvae under extreme starvation. Zebrafish larvae were placed in 96-well plates at fourth day postfertilization (dpf) and larvae were not fed at all from hatching to cease. Zdf1 zebrafish line was used, a strain carrying the (cancer) pathogenic TP53-M214K amino acid substitution. TP53-M214 corresponds to the human TP53-M246 and both residues are located on the DNA-binding domain of the p53 protein. Survival statistical analysis did not show any significant difference in the overall survival rates between homozygous mutant and wild-type larvae. When considering 15 dpf as the endpoint of the experiment (66% of larvae died), a borderline statistical significance was observed for the dominant model of inheritance (p = 0.015; relative hazard = 0.8320). Despite the fact yolk sac of larvae is depleted at 7-8 dpf, 34% of larvae survive until 15 dpf and 1.5% until 17 dpf. Concluding, three main results derive from this study: (1) pathogenic homozygous mutations in TP53 probably do not alter survival rates of zebrafish larvae under starvation; (2) zebrafish larvae can live up to 17 dpf without food, surviving only with their initial nutritional supplies; and (3) an easy and affordable protocol has been developed for estimating survival rates of zebrafish larvae under stressful conditions." @default.
- W4224012292 created "2022-04-19" @default.
- W4224012292 creator A5048901221 @default.
- W4224012292 creator A5084515988 @default.
- W4224012292 creator A5087286581 @default.
- W4224012292 date "2022-04-01" @default.
- W4224012292 modified "2023-09-29" @default.
- W4224012292 title "<i>TP53</i> Mutant Versus Wild-Type Zebrafish Larvae Under Starvation Stress: Larvae Can Live Up to 17 Days Post-Fertilization Without Food" @default.
- W4224012292 cites W1495283866 @default.
- W4224012292 cites W1829094263 @default.
- W4224012292 cites W1971985117 @default.
- W4224012292 cites W1985313868 @default.
- W4224012292 cites W2011881782 @default.
- W4224012292 cites W2037024229 @default.
- W4224012292 cites W2047610979 @default.
- W4224012292 cites W2052568053 @default.
- W4224012292 cites W2057141021 @default.
- W4224012292 cites W2064422983 @default.
- W4224012292 cites W2064653829 @default.
- W4224012292 cites W2079386540 @default.
- W4224012292 cites W2096768072 @default.
- W4224012292 cites W2097260622 @default.
- W4224012292 cites W2117935723 @default.
- W4224012292 cites W2141059025 @default.
- W4224012292 cites W2146366384 @default.
- W4224012292 cites W2155117797 @default.
- W4224012292 cites W2161033160 @default.
- W4224012292 cites W2583111070 @default.
- W4224012292 cites W2751873397 @default.
- W4224012292 cites W2790420126 @default.
- W4224012292 cites W2889777846 @default.
- W4224012292 cites W3029167267 @default.
- W4224012292 cites W3130938392 @default.
- W4224012292 doi "https://doi.org/10.1089/zeb.2022.0003" @default.
- W4224012292 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35417275" @default.
- W4224012292 hasPublicationYear "2022" @default.
- W4224012292 type Work @default.
- W4224012292 citedByCount "4" @default.
- W4224012292 countsByYear W42240122922023 @default.
- W4224012292 crossrefType "journal-article" @default.
- W4224012292 hasAuthorship W4224012292A5048901221 @default.
- W4224012292 hasAuthorship W4224012292A5084515988 @default.
- W4224012292 hasAuthorship W4224012292A5087286581 @default.
- W4224012292 hasConcept C104317684 @default.
- W4224012292 hasConcept C140793950 @default.
- W4224012292 hasConcept C143065580 @default.
- W4224012292 hasConcept C173758957 @default.
- W4224012292 hasConcept C18903297 @default.
- W4224012292 hasConcept C196843134 @default.
- W4224012292 hasConcept C19843653 @default.
- W4224012292 hasConcept C207583985 @default.
- W4224012292 hasConcept C2776878037 @default.
- W4224012292 hasConcept C2777043721 @default.
- W4224012292 hasConcept C2777744765 @default.
- W4224012292 hasConcept C54355233 @default.
- W4224012292 hasConcept C86803240 @default.
- W4224012292 hasConcept C88972607 @default.
- W4224012292 hasConcept C90856448 @default.
- W4224012292 hasConceptScore W4224012292C104317684 @default.
- W4224012292 hasConceptScore W4224012292C140793950 @default.
- W4224012292 hasConceptScore W4224012292C143065580 @default.
- W4224012292 hasConceptScore W4224012292C173758957 @default.
- W4224012292 hasConceptScore W4224012292C18903297 @default.
- W4224012292 hasConceptScore W4224012292C196843134 @default.
- W4224012292 hasConceptScore W4224012292C19843653 @default.
- W4224012292 hasConceptScore W4224012292C207583985 @default.
- W4224012292 hasConceptScore W4224012292C2776878037 @default.
- W4224012292 hasConceptScore W4224012292C2777043721 @default.
- W4224012292 hasConceptScore W4224012292C2777744765 @default.
- W4224012292 hasConceptScore W4224012292C54355233 @default.
- W4224012292 hasConceptScore W4224012292C86803240 @default.
- W4224012292 hasConceptScore W4224012292C88972607 @default.
- W4224012292 hasConceptScore W4224012292C90856448 @default.
- W4224012292 hasIssue "2" @default.
- W4224012292 hasLocation W42240122921 @default.
- W4224012292 hasLocation W42240122922 @default.
- W4224012292 hasOpenAccess W4224012292 @default.
- W4224012292 hasPrimaryLocation W42240122921 @default.
- W4224012292 hasRelatedWork W1969691684 @default.
- W4224012292 hasRelatedWork W2060312105 @default.
- W4224012292 hasRelatedWork W2061239456 @default.
- W4224012292 hasRelatedWork W2074475942 @default.
- W4224012292 hasRelatedWork W2080106883 @default.
- W4224012292 hasRelatedWork W2098399456 @default.
- W4224012292 hasRelatedWork W2124543278 @default.
- W4224012292 hasRelatedWork W2352614228 @default.
- W4224012292 hasRelatedWork W2368081943 @default.
- W4224012292 hasRelatedWork W2904991804 @default.
- W4224012292 hasVolume "19" @default.
- W4224012292 isParatext "false" @default.
- W4224012292 isRetracted "false" @default.
- W4224012292 workType "article" @default.