Matches in SemOpenAlex for { <https://semopenalex.org/work/W4224014784> ?p ?o ?g. }
- W4224014784 endingPage "4359" @default.
- W4224014784 startingPage "4359" @default.
- W4224014784 abstract "The recent development of mRNA vaccines against the SARS-CoV-2 infection has turned the spotlight on the potential of nucleic acids as innovative prophylactic agents and as diagnostic and therapeutic tools. Until now, their use has been severely limited by their reduced half-life in the biological environment and the difficulties related to their transport to target cells. These limiting aspects can now be overcome by resorting to chemical modifications in the drug and using appropriate nanocarriers, respectively. Oligonucleotides can interact with complementary sequences of nucleic acid targets, forming stable complexes and determining their loss of function. An alternative strategy uses nucleic acid aptamers that, like the antibodies, bind to specific proteins to modulate their activity. In this review, the authors will examine the recent literature on nucleic acids-based strategies in the COVID-19 era, focusing the attention on their applications for the prophylaxis of COVID-19, but also on antisense- and aptamer-based strategies directed to the diagnosis and therapy of the coronavirus pandemic." @default.
- W4224014784 created "2022-04-19" @default.
- W4224014784 creator A5006610844 @default.
- W4224014784 creator A5055516982 @default.
- W4224014784 creator A5057021537 @default.
- W4224014784 creator A5066694645 @default.
- W4224014784 creator A5073525219 @default.
- W4224014784 creator A5090690124 @default.
- W4224014784 date "2022-04-14" @default.
- W4224014784 modified "2023-09-25" @default.
- W4224014784 title "Nucleic Acids as Biotools at the Interface between Chemistry and Nanomedicine in the COVID-19 Era" @default.
- W4224014784 cites W1420726270 @default.
- W4224014784 cites W1978433099 @default.
- W4224014784 cites W1989577491 @default.
- W4224014784 cites W2002089022 @default.
- W4224014784 cites W2010006194 @default.
- W4224014784 cites W2026370504 @default.
- W4224014784 cites W2035645019 @default.
- W4224014784 cites W2052626751 @default.
- W4224014784 cites W2064673889 @default.
- W4224014784 cites W2073201361 @default.
- W4224014784 cites W2080940607 @default.
- W4224014784 cites W2086470405 @default.
- W4224014784 cites W2088281232 @default.
- W4224014784 cites W2089477917 @default.
- W4224014784 cites W2117529527 @default.
- W4224014784 cites W2131411258 @default.
- W4224014784 cites W2180304330 @default.
- W4224014784 cites W2255246323 @default.
- W4224014784 cites W2331101989 @default.
- W4224014784 cites W2551596483 @default.
- W4224014784 cites W2732527862 @default.
- W4224014784 cites W2781546028 @default.
- W4224014784 cites W2789285266 @default.
- W4224014784 cites W2794033668 @default.
- W4224014784 cites W2808976233 @default.
- W4224014784 cites W2809411731 @default.
- W4224014784 cites W2885127928 @default.
- W4224014784 cites W2894823011 @default.
- W4224014784 cites W2895155188 @default.
- W4224014784 cites W2897142532 @default.
- W4224014784 cites W2901705732 @default.
- W4224014784 cites W2909415609 @default.
- W4224014784 cites W2914060533 @default.
- W4224014784 cites W2921362401 @default.
- W4224014784 cites W2955541365 @default.
- W4224014784 cites W2983464809 @default.
- W4224014784 cites W2999143653 @default.
- W4224014784 cites W2999860583 @default.
- W4224014784 cites W3000583872 @default.
- W4224014784 cites W3012550011 @default.
- W4224014784 cites W3015464552 @default.
- W4224014784 cites W3015855205 @default.
- W4224014784 cites W3015973618 @default.
- W4224014784 cites W3017680297 @default.
- W4224014784 cites W3017964030 @default.
- W4224014784 cites W3019866779 @default.
- W4224014784 cites W3021028979 @default.
- W4224014784 cites W3025143393 @default.
- W4224014784 cites W3044336785 @default.
- W4224014784 cites W3047091198 @default.
- W4224014784 cites W3047363261 @default.
- W4224014784 cites W3048585700 @default.
- W4224014784 cites W3082246640 @default.
- W4224014784 cites W3091134219 @default.
- W4224014784 cites W3092490057 @default.
- W4224014784 cites W3093378568 @default.
- W4224014784 cites W3094560806 @default.
- W4224014784 cites W3094827588 @default.
- W4224014784 cites W3095878053 @default.
- W4224014784 cites W3102636871 @default.
- W4224014784 cites W3115737775 @default.
- W4224014784 cites W3116163512 @default.
- W4224014784 cites W3116376362 @default.
- W4224014784 cites W3118351707 @default.
- W4224014784 cites W3121703251 @default.
- W4224014784 cites W3122581684 @default.
- W4224014784 cites W3124144456 @default.
- W4224014784 cites W3126017645 @default.
- W4224014784 cites W3126770396 @default.
- W4224014784 cites W3127145950 @default.
- W4224014784 cites W3127353402 @default.
- W4224014784 cites W3127514965 @default.
- W4224014784 cites W3127898627 @default.
- W4224014784 cites W3128109310 @default.
- W4224014784 cites W3128460661 @default.
- W4224014784 cites W3128564782 @default.
- W4224014784 cites W3129268422 @default.
- W4224014784 cites W3129485769 @default.
- W4224014784 cites W3130483557 @default.
- W4224014784 cites W3130729977 @default.
- W4224014784 cites W3132802838 @default.
- W4224014784 cites W3135684667 @default.
- W4224014784 cites W3148255637 @default.
- W4224014784 cites W3150352671 @default.
- W4224014784 cites W3154965281 @default.
- W4224014784 cites W3157625399 @default.
- W4224014784 cites W3158180440 @default.