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- W4224021424 abstract "Abstract Background/Purpose The aim of this study was to assess whether the duration of adjuvant gemcitabine plus S‐1 (GS) chemotherapy has any effect on survival in patients with pancreatic ductal adenocarcinoma (PDAC). Methods Of the 290 patients who received adjuvant GS chemotherapy, 100 (34%) received the standard duration (20‐29 weeks) and 190 (66%) received an extended duration (≥30 weeks). To reduce selection bias, the prognostic impact (recurrence‐free survival [RFS] and overall survival [OS]) based on the duration of adjuvant GS chemotherapy was analyzed using inverse probability of treatment weighting (IPTW). Moreover, to reduce immortal time bias, time‐dependent multivariate analyses in which implementation of adjuvant GS chemotherapy was treated as time‐varying covariate was also performed. Results Extended duration of adjuvant GS chemotherapy was significantly correlated with prolonged RFS ( P < .001) and OS ( P < .001) after IPTW adjustment. Time‐dependent multivariate analyses revealed that extended duration of adjuvant GS chemotherapy was an independent prognostic factor for prolonged RFS (hazard ratio [HR], 0.58, P = .002) and OS (HR, 0.56, P = .005). Conclusion Extended duration (≥30 weeks) of adjuvant GS chemotherapy in patients with PDAC was associated with an improved prognosis. These findings warrant a further prospective trial on PDAC to investigate the survival benefit of extended adjuvant chemotherapy." @default.
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- W4224021424 date "2022-05-09" @default.
- W4224021424 modified "2023-10-02" @default.
- W4224021424 title "Prognosis following an extended duration of adjuvant gemcitabine plus S‐1 chemotherapy in patients with pancreatic ductal adenocarcinoma: Analysis using inverse probability of treatment weighting" @default.
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- W4224021424 doi "https://doi.org/10.1002/jhbp.1151" @default.
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