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- W4224032831 abstract "Abstract Dysregulation of protein prenylation has been implicated in many diseases, including Alzheimer’s disease (AD). Prenylomic analysis, the combination of metabolic incorporation of an isoprenoid analogue (C15AlkOPP) into prenylated proteins with a bottom-up proteomic analysis, has allowed identification of prenylated proteins in various cellular models. Here, transgenic AD mice were administered with C15AlkOPP through intracerebroventricular (ICV) infusion over 13 days. Using prenylomic analysis, 36 prenylated proteins were enriched in the brains of AD mice. Importantly, the prenylated forms of 15 proteins were consistently upregulated in AD mice compared to non-transgenic wild-type controls. These results highlight the power of this in vivo metabolic labeling approach to identify multiple post-translationally modified proteins that may serve as potential therapeutic targets for a disease that has proved refractory to treatment thus far. Moreover, this method should be applicable to many other types of protein modifications, significantly broadening its scope." @default.
- W4224032831 created "2022-04-19" @default.
- W4224032831 creator A5032523439 @default.
- W4224032831 creator A5045212838 @default.
- W4224032831 creator A5048332389 @default.
- W4224032831 creator A5056329233 @default.
- W4224032831 creator A5071110237 @default.
- W4224032831 date "2022-04-01" @default.
- W4224032831 modified "2023-10-16" @default.
- W4224032831 title "<i>In vivo</i> prenylomic profiling in the brain of a transgenic mouse model of Alzheimer’s disease reveals increased prenylation of a key set of proteins" @default.
- W4224032831 cites W1622252351 @default.
- W4224032831 cites W1938649209 @default.
- W4224032831 cites W1971235233 @default.
- W4224032831 cites W1974040473 @default.
- W4224032831 cites W1974563225 @default.
- W4224032831 cites W1975141413 @default.
- W4224032831 cites W1977860801 @default.
- W4224032831 cites W1979071042 @default.
- W4224032831 cites W1979120432 @default.
- W4224032831 cites W1993820843 @default.
- W4224032831 cites W2002042549 @default.
- W4224032831 cites W2002156115 @default.
- W4224032831 cites W2003516452 @default.
- W4224032831 cites W2005739560 @default.
- W4224032831 cites W2014194703 @default.
- W4224032831 cites W2015070415 @default.
- W4224032831 cites W2018647432 @default.
- W4224032831 cites W2023060014 @default.
- W4224032831 cites W2026776421 @default.
- W4224032831 cites W2032920422 @default.
- W4224032831 cites W2033505501 @default.
- W4224032831 cites W2040171181 @default.
- W4224032831 cites W2040711118 @default.
- W4224032831 cites W2043616174 @default.
- W4224032831 cites W2045387875 @default.
- W4224032831 cites W2047613132 @default.
- W4224032831 cites W2051748475 @default.
- W4224032831 cites W2055911520 @default.
- W4224032831 cites W2057095204 @default.
- W4224032831 cites W2059346427 @default.
- W4224032831 cites W2063432830 @default.
- W4224032831 cites W2067991812 @default.
- W4224032831 cites W2076495844 @default.
- W4224032831 cites W2078201172 @default.
- W4224032831 cites W2080536654 @default.
- W4224032831 cites W2087980392 @default.
- W4224032831 cites W2090465745 @default.
- W4224032831 cites W2099664947 @default.
- W4224032831 cites W2101468172 @default.
- W4224032831 cites W2110293902 @default.
- W4224032831 cites W2116234410 @default.
- W4224032831 cites W2119961485 @default.
- W4224032831 cites W2130690907 @default.
- W4224032831 cites W2133246053 @default.
- W4224032831 cites W2138178640 @default.
- W4224032831 cites W2145144183 @default.
- W4224032831 cites W2167069331 @default.
- W4224032831 cites W2168947921 @default.
- W4224032831 cites W2169393803 @default.
- W4224032831 cites W2176744910 @default.
- W4224032831 cites W2184141090 @default.
- W4224032831 cites W2235034178 @default.
- W4224032831 cites W2272329318 @default.
- W4224032831 cites W2278258332 @default.
- W4224032831 cites W2324956847 @default.
- W4224032831 cites W2343512682 @default.
- W4224032831 cites W2428905495 @default.
- W4224032831 cites W2440302549 @default.
- W4224032831 cites W2462492481 @default.
- W4224032831 cites W2496155946 @default.
- W4224032831 cites W2516612281 @default.
- W4224032831 cites W2559831276 @default.
- W4224032831 cites W2568696189 @default.
- W4224032831 cites W2582498840 @default.
- W4224032831 cites W2667171523 @default.
- W4224032831 cites W2768580979 @default.
- W4224032831 cites W2768955389 @default.
- W4224032831 cites W2775724624 @default.
- W4224032831 cites W2782354676 @default.
- W4224032831 cites W2793712255 @default.
- W4224032831 cites W2797913249 @default.
- W4224032831 cites W2800620204 @default.
- W4224032831 cites W2802487502 @default.
- W4224032831 cites W2887193453 @default.
- W4224032831 cites W2889255537 @default.
- W4224032831 cites W2890669664 @default.
- W4224032831 cites W2893833768 @default.
- W4224032831 cites W2933803463 @default.
- W4224032831 cites W2947114801 @default.
- W4224032831 cites W2969462190 @default.
- W4224032831 cites W2977367243 @default.
- W4224032831 cites W2984841973 @default.
- W4224032831 cites W2990324610 @default.
- W4224032831 cites W3019435489 @default.
- W4224032831 cites W3038331806 @default.
- W4224032831 cites W3044540488 @default.
- W4224032831 cites W3094281615 @default.
- W4224032831 cites W3124177967 @default.
- W4224032831 cites W3127380522 @default.
- W4224032831 cites W3137972505 @default.