Matches in SemOpenAlex for { <https://semopenalex.org/work/W4224032924> ?p ?o ?g. }
- W4224032924 endingPage "112495" @default.
- W4224032924 startingPage "112495" @default.
- W4224032924 abstract "A significant bottleneck in the clinical translation of stem cells remains eliciting the desired stem cell behavior once transplanted in the body. In their natural environment, stem cell fate is regulated by their interaction with extracellular matrix (ECM), mainly through integrin-mediated cell adhesion. 2D biointerfaces that selectively present ECM-derived ligands can be used as valuable tools to study and improve our understanding on how stem cells interact with their environment. Here we developed a new type of biointerface based on mesoporous silica nanoparticles (MSN) which are interesting nanomaterials for biointerface engineering because they allow close control over surface physiochemical properties. To create the platform, DNA functionalized MSN (MSN-ssDNA) with varying PEG linker length were developed. Cell adhesion tripeptide RGD was conjugated to a complementary DNA strand, which could specifically bind to MSN-ssDNA to create MSN-dsDNA-RGD films. We showed that MSN-dsDNA-RGD films could promote hMSCs adhesion and spreading, whereas MSN-dsDNA films without RGD resulted in poor cell spreading with round morphology, and low cell adhesion. In addition, we showed that cell adhesion to the films is PEG length-dependent. The design of the platform allows easy incorporation of other and multiple ECM ligands, as well as soluble cues, making MSN-ssDNA based biointerfaces a novel tool to study ligand-stem cell interactions." @default.
- W4224032924 created "2022-04-19" @default.
- W4224032924 creator A5007398191 @default.
- W4224032924 creator A5048157309 @default.
- W4224032924 date "2022-07-01" @default.
- W4224032924 modified "2023-10-18" @default.
- W4224032924 title "DNA modified MSN-films as versatile biointerfaces to study stem cell adhesion processes" @default.
- W4224032924 cites W1558949171 @default.
- W4224032924 cites W1972911951 @default.
- W4224032924 cites W1991280014 @default.
- W4224032924 cites W1993390114 @default.
- W4224032924 cites W2023026872 @default.
- W4224032924 cites W2029378543 @default.
- W4224032924 cites W2031009001 @default.
- W4224032924 cites W2036268826 @default.
- W4224032924 cites W2040810212 @default.
- W4224032924 cites W2046893115 @default.
- W4224032924 cites W2053442544 @default.
- W4224032924 cites W2062957606 @default.
- W4224032924 cites W2077011808 @default.
- W4224032924 cites W2102495865 @default.
- W4224032924 cites W2109137926 @default.
- W4224032924 cites W2141652440 @default.
- W4224032924 cites W2141738357 @default.
- W4224032924 cites W2164275581 @default.
- W4224032924 cites W2165602028 @default.
- W4224032924 cites W2168816644 @default.
- W4224032924 cites W2262093596 @default.
- W4224032924 cites W2422036767 @default.
- W4224032924 cites W2475831462 @default.
- W4224032924 cites W2561709719 @default.
- W4224032924 cites W2590432791 @default.
- W4224032924 cites W2615496904 @default.
- W4224032924 cites W2744141074 @default.
- W4224032924 cites W2799356317 @default.
- W4224032924 cites W2800838020 @default.
- W4224032924 cites W2889342873 @default.
- W4224032924 cites W2889530976 @default.
- W4224032924 cites W2923614429 @default.
- W4224032924 cites W2927890113 @default.
- W4224032924 cites W2940448258 @default.
- W4224032924 cites W2942553366 @default.
- W4224032924 cites W2954307213 @default.
- W4224032924 cites W2977948085 @default.
- W4224032924 cites W2995228706 @default.
- W4224032924 cites W3006172684 @default.
- W4224032924 cites W3033368453 @default.
- W4224032924 cites W3034519122 @default.
- W4224032924 cites W3105734790 @default.
- W4224032924 cites W3119341379 @default.
- W4224032924 cites W3181514280 @default.
- W4224032924 cites W3198772838 @default.
- W4224032924 cites W597290641 @default.
- W4224032924 cites W601597204 @default.
- W4224032924 doi "https://doi.org/10.1016/j.colsurfb.2022.112495" @default.
- W4224032924 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35429737" @default.
- W4224032924 hasPublicationYear "2022" @default.
- W4224032924 type Work @default.
- W4224032924 citedByCount "2" @default.
- W4224032924 countsByYear W42240329242022 @default.
- W4224032924 countsByYear W42240329242023 @default.
- W4224032924 crossrefType "journal-article" @default.
- W4224032924 hasAuthorship W4224032924A5007398191 @default.
- W4224032924 hasAuthorship W4224032924A5048157309 @default.
- W4224032924 hasBestOaLocation W42240329241 @default.
- W4224032924 hasConcept C115537861 @default.
- W4224032924 hasConcept C12554922 @default.
- W4224032924 hasConcept C136229726 @default.
- W4224032924 hasConcept C147789679 @default.
- W4224032924 hasConcept C1491633281 @default.
- W4224032924 hasConcept C171250308 @default.
- W4224032924 hasConcept C178790620 @default.
- W4224032924 hasConcept C185592680 @default.
- W4224032924 hasConcept C189165786 @default.
- W4224032924 hasConcept C192562407 @default.
- W4224032924 hasConcept C2781308654 @default.
- W4224032924 hasConcept C28328180 @default.
- W4224032924 hasConcept C49892992 @default.
- W4224032924 hasConcept C55493867 @default.
- W4224032924 hasConcept C71924100 @default.
- W4224032924 hasConcept C84416704 @default.
- W4224032924 hasConcept C85789140 @default.
- W4224032924 hasConcept C86803240 @default.
- W4224032924 hasConcept C95444343 @default.
- W4224032924 hasConceptScore W4224032924C115537861 @default.
- W4224032924 hasConceptScore W4224032924C12554922 @default.
- W4224032924 hasConceptScore W4224032924C136229726 @default.
- W4224032924 hasConceptScore W4224032924C147789679 @default.
- W4224032924 hasConceptScore W4224032924C1491633281 @default.
- W4224032924 hasConceptScore W4224032924C171250308 @default.
- W4224032924 hasConceptScore W4224032924C178790620 @default.
- W4224032924 hasConceptScore W4224032924C185592680 @default.
- W4224032924 hasConceptScore W4224032924C189165786 @default.
- W4224032924 hasConceptScore W4224032924C192562407 @default.
- W4224032924 hasConceptScore W4224032924C2781308654 @default.
- W4224032924 hasConceptScore W4224032924C28328180 @default.
- W4224032924 hasConceptScore W4224032924C49892992 @default.
- W4224032924 hasConceptScore W4224032924C55493867 @default.