FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4224042852> ?p ?o ?g. }

• W4224042852 abstract "Abstract Background Metastasis leads to recurrence and death in colorectal cancer (CRC) patients; however, mechanisms underlying CRC metastasis, especially in its initial stages, remain largely unknown. In this study, we aim to identify long noncoding RNAs (lncRNAs) functionally involved in CRC metastasis initiation and their regulation that could lead to targeted therapeutics. Methods We performed whole transcriptome sequencing using CRC cell lines with divergent spontaneous metastatic properties. The biological roles and mechanisms of lncRNA MIR99AHG were characterized with a series of in vitro and in vivo models and molecular analyses. Results MIR99AHG was upregulated in CRC patients and associated with tumor stage and prognosis. MIR99AHG potently drove migration, invasion and metastasis in CRC cells, and these effects were dependent on its role in promoting invadopodia formation. MIR99AHG interacted with RNA splicing factor PTBP1, which cooperatively modulated alternative splicing of chromatin remodeling gene SMARCA1. Mechanistically, MIR99AHG acted as an address label for PTBP1 to direct its binding to the 5’ splice site of SMARCA1 intron 12, thereby facilitating inclusion of the alternative exon 13 to generate a long isoform (SMARCA1-L). The canonical SMARCA1 inhibited cell migration and invasion and suppressed a core set of genes involved in invadopodia, but the SMARCA1-L was functionally inert in metastasis suppression. Clinically, SMARCA1-L levels were positively correlated with MIR99AHG and PTBP1 in patients with metastatic CRC. Conclusions This study identified that invadopodia was regulated by a splicing switch of SMARCA1 due to the interaction between MIR99AHG and PTBP1, highlighting a novel regulatory mode mediated by lncRNA in alternative splicing of chromatin remodeler during CRC metastasis." @default.
• W4224042852 created "2022-04-19" @default.
• W4224042852 creator A5005706767 @default.
• W4224042852 creator A5007247087 @default.
• W4224042852 creator A5007966510 @default.
• W4224042852 creator A5017032739 @default.
• W4224042852 creator A5019942906 @default.
• W4224042852 creator A5023229396 @default.
• W4224042852 creator A5025435703 @default.
• W4224042852 creator A5029851581 @default.
• W4224042852 creator A5037677450 @default.
• W4224042852 creator A5040284436 @default.
• W4224042852 creator A5044695931 @default.
• W4224042852 creator A5046054581 @default.
• W4224042852 creator A5055801372 @default.
• W4224042852 creator A5057840497 @default.
• W4224042852 creator A5062616205 @default.
• W4224042852 creator A5067538557 @default.
• W4224042852 creator A5072861069 @default.
• W4224042852 creator A5074266150 @default.
• W4224042852 creator A5080177287 @default.
• W4224042852 creator A5082030295 @default.
• W4224042852 creator A5084529927 @default.
• W4224042852 creator A5085028455 @default.
• W4224042852 creator A5088664989 @default.
• W4224042852 creator A5090617575 @default.
• W4224042852 date "2022-04-13" @default.
• W4224042852 modified "2023-10-18" @default.
• W4224042852 title "MIR99AHG promotes invadopodia formation in colorectal cancer metastasis by tuning PTBP1-mediated splicing modulation of SMARCA1" @default.
• W4224042852 doi "https://doi.org/10.21203/rs.3.rs-1538014/v1" @default.
• W4224042852 hasPublicationYear "2022" @default.
• W4224042852 type Work @default.
• W4224042852 citedByCount "0" @default.
• W4224042852 crossrefType "posted-content" @default.
• W4224042852 hasAuthorship W4224042852A5005706767 @default.
• W4224042852 hasAuthorship W4224042852A5007247087 @default.
• W4224042852 hasAuthorship W4224042852A5007966510 @default.
• W4224042852 hasAuthorship W4224042852A5017032739 @default.
• W4224042852 hasAuthorship W4224042852A5019942906 @default.
• W4224042852 hasAuthorship W4224042852A5023229396 @default.
• W4224042852 hasAuthorship W4224042852A5025435703 @default.
• W4224042852 hasAuthorship W4224042852A5029851581 @default.
• W4224042852 hasAuthorship W4224042852A5037677450 @default.
• W4224042852 hasAuthorship W4224042852A5040284436 @default.
• W4224042852 hasAuthorship W4224042852A5044695931 @default.
• W4224042852 hasAuthorship W4224042852A5046054581 @default.
• W4224042852 hasAuthorship W4224042852A5055801372 @default.
• W4224042852 hasAuthorship W4224042852A5057840497 @default.
• W4224042852 hasAuthorship W4224042852A5062616205 @default.
• W4224042852 hasAuthorship W4224042852A5067538557 @default.
• W4224042852 hasAuthorship W4224042852A5072861069 @default.
• W4224042852 hasAuthorship W4224042852A5074266150 @default.
• W4224042852 hasAuthorship W4224042852A5080177287 @default.
• W4224042852 hasAuthorship W4224042852A5082030295 @default.
• W4224042852 hasAuthorship W4224042852A5084529927 @default.
• W4224042852 hasAuthorship W4224042852A5085028455 @default.
• W4224042852 hasAuthorship W4224042852A5088664989 @default.
• W4224042852 hasAuthorship W4224042852A5090617575 @default.
• W4224042852 hasBestOaLocation W42240428521 @default.
• W4224042852 hasConcept C104317684 @default.
• W4224042852 hasConcept C121608353 @default.
• W4224042852 hasConcept C127561419 @default.
• W4224042852 hasConcept C150194340 @default.
• W4224042852 hasConcept C162317418 @default.
• W4224042852 hasConcept C194583182 @default.
• W4224042852 hasConcept C200786668 @default.
• W4224042852 hasConcept C2779013556 @default.
• W4224042852 hasConcept C36823959 @default.
• W4224042852 hasConcept C502942594 @default.
• W4224042852 hasConcept C526805850 @default.
• W4224042852 hasConcept C54355233 @default.
• W4224042852 hasConcept C54458228 @default.
• W4224042852 hasConcept C62203573 @default.
• W4224042852 hasConcept C67705224 @default.
• W4224042852 hasConcept C73758832 @default.
• W4224042852 hasConcept C86803240 @default.
• W4224042852 hasConcept C95444343 @default.
• W4224042852 hasConceptScore W4224042852C104317684 @default.
• W4224042852 hasConceptScore W4224042852C121608353 @default.
• W4224042852 hasConceptScore W4224042852C127561419 @default.
• W4224042852 hasConceptScore W4224042852C150194340 @default.
• W4224042852 hasConceptScore W4224042852C162317418 @default.
• W4224042852 hasConceptScore W4224042852C194583182 @default.
• W4224042852 hasConceptScore W4224042852C200786668 @default.
• W4224042852 hasConceptScore W4224042852C2779013556 @default.
• W4224042852 hasConceptScore W4224042852C36823959 @default.
• W4224042852 hasConceptScore W4224042852C502942594 @default.
• W4224042852 hasConceptScore W4224042852C526805850 @default.
• W4224042852 hasConceptScore W4224042852C54355233 @default.
• W4224042852 hasConceptScore W4224042852C54458228 @default.
• W4224042852 hasConceptScore W4224042852C62203573 @default.
• W4224042852 hasConceptScore W4224042852C67705224 @default.
• W4224042852 hasConceptScore W4224042852C73758832 @default.
• W4224042852 hasConceptScore W4224042852C86803240 @default.
• W4224042852 hasConceptScore W4224042852C95444343 @default.
• W4224042852 hasLocation W42240428521 @default.
• W4224042852 hasOpenAccess W4224042852 @default.
• W4224042852 hasPrimaryLocation W42240428521 @default.
• W4224042852 hasRelatedWork W1168651000 @default.
• W4224042852 hasRelatedWork W1532771184 @default.

• next