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- W4224046875 endingPage "385" @default.
- W4224046875 startingPage "376" @default.
- W4224046875 abstract "RNA helicases are the largest class of enzymes in eukaryotic RNA metabolism. In cells, protein cofactors regulate RNA helicase functions and impact biochemical helicase activities. Understanding how cofactors affect enzymatic activities of RNA helicases is thus critical for delineating physical roles and regulation of RNA helicases in cells. Here, we discuss approaches and conceptual considerations for the design of experiments to interrogate cofactor effects on RNA helicase activities in vitro. We outline the mechanistic frame for helicase reactions, discuss optimization of experimental setup and reaction parameters for measuring cofactor effects on RNA helicase activities, and provide basic guides to data analysis and interpretation. The described approaches are also instructive for determining the impact of small molecule inhibitors of RNA helicases." @default.
- W4224046875 created "2022-04-19" @default.
- W4224046875 creator A5046027282 @default.
- W4224046875 creator A5077256593 @default.
- W4224046875 date "2022-08-01" @default.
- W4224046875 modified "2023-10-16" @default.
- W4224046875 title "Measuring the impact of cofactors on RNA helicase activities" @default.
- W4224046875 cites W134539665 @default.
- W4224046875 cites W1496462301 @default.
- W4224046875 cites W1513995144 @default.
- W4224046875 cites W1557800628 @default.
- W4224046875 cites W1588519390 @default.
- W4224046875 cites W1732942398 @default.
- W4224046875 cites W1828984543 @default.
- W4224046875 cites W1886707102 @default.
- W4224046875 cites W1934704664 @default.
- W4224046875 cites W1964099889 @default.
- W4224046875 cites W1964233945 @default.
- W4224046875 cites W1964617791 @default.
- W4224046875 cites W1965681005 @default.
- W4224046875 cites W1965892231 @default.
- W4224046875 cites W1969974585 @default.
- W4224046875 cites W1977592786 @default.
- W4224046875 cites W1981848417 @default.
- W4224046875 cites W1998885514 @default.
- W4224046875 cites W2001814758 @default.
- W4224046875 cites W2003993220 @default.
- W4224046875 cites W2015007243 @default.
- W4224046875 cites W2017866593 @default.
- W4224046875 cites W2022193493 @default.
- W4224046875 cites W2024536332 @default.
- W4224046875 cites W2025232919 @default.
- W4224046875 cites W2029971914 @default.
- W4224046875 cites W2030677655 @default.
- W4224046875 cites W2033346520 @default.
- W4224046875 cites W2034737176 @default.
- W4224046875 cites W2035832119 @default.
- W4224046875 cites W2036387553 @default.
- W4224046875 cites W2037978116 @default.
- W4224046875 cites W2038872813 @default.
- W4224046875 cites W2039885485 @default.
- W4224046875 cites W2041008570 @default.
- W4224046875 cites W2041737563 @default.
- W4224046875 cites W2043213657 @default.
- W4224046875 cites W2044199405 @default.
- W4224046875 cites W2047191568 @default.
- W4224046875 cites W2051537724 @default.
- W4224046875 cites W2051848082 @default.
- W4224046875 cites W2055821798 @default.
- W4224046875 cites W2056657474 @default.
- W4224046875 cites W2057990302 @default.
- W4224046875 cites W2065868028 @default.
- W4224046875 cites W2068835587 @default.
- W4224046875 cites W2070394525 @default.
- W4224046875 cites W2072840805 @default.
- W4224046875 cites W2076355407 @default.
- W4224046875 cites W2078532539 @default.
- W4224046875 cites W2085697301 @default.
- W4224046875 cites W2085780952 @default.
- W4224046875 cites W2089572307 @default.
- W4224046875 cites W2090138073 @default.
- W4224046875 cites W2091297785 @default.
- W4224046875 cites W2096365000 @default.
- W4224046875 cites W2104974597 @default.
- W4224046875 cites W2104977828 @default.
- W4224046875 cites W2109702558 @default.
- W4224046875 cites W2113995228 @default.
- W4224046875 cites W2125655241 @default.
- W4224046875 cites W2127003607 @default.
- W4224046875 cites W2129183636 @default.
- W4224046875 cites W2130437495 @default.
- W4224046875 cites W2133168268 @default.
- W4224046875 cites W2135972242 @default.
- W4224046875 cites W2136495792 @default.
- W4224046875 cites W2149550436 @default.
- W4224046875 cites W2158855280 @default.
- W4224046875 cites W2161208925 @default.
- W4224046875 cites W2166288313 @default.
- W4224046875 cites W2171698890 @default.
- W4224046875 cites W2212235774 @default.
- W4224046875 cites W2256482451 @default.
- W4224046875 cites W2272624281 @default.
- W4224046875 cites W2276393280 @default.
- W4224046875 cites W2306300251 @default.
- W4224046875 cites W2319835043 @default.
- W4224046875 cites W2397313273 @default.
- W4224046875 cites W2414203456 @default.
- W4224046875 cites W2415453642 @default.
- W4224046875 cites W2418993505 @default.
- W4224046875 cites W2420304477 @default.
- W4224046875 cites W2425949876 @default.
- W4224046875 cites W2467196689 @default.
- W4224046875 cites W2469205151 @default.
- W4224046875 cites W2486076694 @default.
- W4224046875 cites W2513169865 @default.
- W4224046875 cites W2533071918 @default.
- W4224046875 cites W2553944168 @default.
- W4224046875 cites W2578197308 @default.