FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4224050235> ?p ?o ?g. }

• W4224050235 endingPage "371" @default.
• W4224050235 startingPage "358" @default.
• W4224050235 abstract "Results of several studies during past years suggested that magnesium phosphate cements (MPCs) not only show excellent biocompatibility and osteoconductivity, but they also provide improved regeneration capacity due to higher solubility compared to calcium phosphates. These findings also highlighted that chemical similarity of bone substitutes to the natural bone tissue is not a determinant factor in the success of regenerative strategies. The aim of this study was to further improve the degradation speed of MPCs for a fast bone ingrowth within a few months. We confirmed our hypothesis, that decreasing the powder-liquid ratio (PLR) of cement results in an increased content of highly soluble phases such as struvite (MgNH4PO4⋅6H2O) as well as K-struvite (MgKPO4⋅6H2O). Promising compositions with a low PLR of 1 g ml-1 were implanted in partially-loaded tibia defects in sheep. Both cements were partially degraded and replaced by bone tissue after 4 months. The degradation speed of the K-struvite cement was significantly higher compared to the struvite cement, initially resulting in the formation of a cell-rich resorption zone at the surface of some implants, as determined by histology. Overall, both MPCs investigated in this study seem to be promising as an alternative to the clinically well-established, but slowly degrading calcium phosphate cements, depending on defect size and desired degradation rate. Whereas the K-struvite cement might require further modification towards a slower resorption and reduced inflammatory response in vivo, the struvite cement appears promising for the treatment of bone defects due to its continuous degradation with simultaneous new bone formation. STATEMENT OF SIGNIFICANCE: Cold setting bone cements are used for the treatment of bone defects that exceed a critical size and cannot heal on their own. They are applied pasty into the bone defect and harden afterwards so that the shape adapts to the individual defect. Magnesium phosphates such as magnesium ammonium phosphate hexahydrate (struvite) belong to a new class of these cold setting bone cements. They degrade much faster than the clinically established calcium phosphates. In this study, a magnesium phosphate that has hardly been investigated so far was implanted into partially-loaded defects in sheeps: Potassium magnesium phosphate hexahydrate. This showed even faster resorption compared to the struvite cement: after 4 months, 63% of the cement was already degraded." @default.
• W4224050235 created "2022-04-19" @default.
• W4224050235 creator A5002020544 @default.
• W4224050235 creator A5006657051 @default.
• W4224050235 creator A5012121812 @default.
• W4224050235 creator A5025767254 @default.
• W4224050235 creator A5029447343 @default.
• W4224050235 creator A5042483283 @default.
• W4224050235 creator A5065496991 @default.
• W4224050235 creator A5071274944 @default.
• W4224050235 date "2022-06-01" @default.
• W4224050235 modified "2023-10-13" @default.
• W4224050235 title "Accelerated bone regeneration through rational design of magnesium phosphate cements" @default.
• W4224050235 cites W1562125623 @default.
• W4224050235 cites W1654279680 @default.
• W4224050235 cites W1967365998 @default.
• W4224050235 cites W1967476074 @default.
• W4224050235 cites W1970018299 @default.
• W4224050235 cites W1973633438 @default.
• W4224050235 cites W1981510227 @default.
• W4224050235 cites W1985441897 @default.
• W4224050235 cites W1991222088 @default.
• W4224050235 cites W1992902310 @default.
• W4224050235 cites W1995279546 @default.
• W4224050235 cites W2003832763 @default.
• W4224050235 cites W2004649867 @default.
• W4224050235 cites W2004732395 @default.
• W4224050235 cites W2010695444 @default.
• W4224050235 cites W2011677220 @default.
• W4224050235 cites W2011860418 @default.
• W4224050235 cites W2018203158 @default.
• W4224050235 cites W2022326284 @default.
• W4224050235 cites W2027690360 @default.
• W4224050235 cites W2033843049 @default.
• W4224050235 cites W2037640830 @default.
• W4224050235 cites W2043050807 @default.
• W4224050235 cites W2044502023 @default.
• W4224050235 cites W2045821685 @default.
• W4224050235 cites W2049162853 @default.
• W4224050235 cites W2049559839 @default.
• W4224050235 cites W2068322347 @default.
• W4224050235 cites W2070237981 @default.
• W4224050235 cites W2076311012 @default.
• W4224050235 cites W2096425957 @default.
• W4224050235 cites W2099318358 @default.
• W4224050235 cites W2223796212 @default.
• W4224050235 cites W2293676967 @default.
• W4224050235 cites W2364756455 @default.
• W4224050235 cites W249038985 @default.
• W4224050235 cites W2512642355 @default.
• W4224050235 cites W2555801729 @default.
• W4224050235 cites W2767500376 @default.
• W4224050235 cites W2773490851 @default.
• W4224050235 cites W2791338152 @default.
• W4224050235 cites W2794154320 @default.
• W4224050235 cites W2799427964 @default.
• W4224050235 cites W2898475746 @default.
• W4224050235 cites W2904217374 @default.
• W4224050235 cites W2913025510 @default.
• W4224050235 cites W3007474900 @default.
• W4224050235 cites W4220872393 @default.
• W4224050235 cites W2033989592 @default.
• W4224050235 doi "https://doi.org/10.1016/j.actbio.2022.04.019" @default.
• W4224050235 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35443213" @default.
• W4224050235 hasPublicationYear "2022" @default.
• W4224050235 type Work @default.
• W4224050235 citedByCount "13" @default.
• W4224050235 countsByYear W42240502352022 @default.
• W4224050235 countsByYear W42240502352023 @default.
• W4224050235 crossrefType "journal-article" @default.
• W4224050235 hasAuthorship W4224050235A5002020544 @default.
• W4224050235 hasAuthorship W4224050235A5006657051 @default.
• W4224050235 hasAuthorship W4224050235A5012121812 @default.
• W4224050235 hasAuthorship W4224050235A5025767254 @default.
• W4224050235 hasAuthorship W4224050235A5029447343 @default.
• W4224050235 hasAuthorship W4224050235A5042483283 @default.
• W4224050235 hasAuthorship W4224050235A5065496991 @default.
• W4224050235 hasAuthorship W4224050235A5071274944 @default.
• W4224050235 hasConcept C126322002 @default.
• W4224050235 hasConcept C127413603 @default.
• W4224050235 hasConcept C142724271 @default.
• W4224050235 hasConcept C146562846 @default.
• W4224050235 hasConcept C159985019 @default.
• W4224050235 hasConcept C185592680 @default.
• W4224050235 hasConcept C191897082 @default.
• W4224050235 hasConcept C192562407 @default.
• W4224050235 hasConcept C2777132085 @default.
• W4224050235 hasConcept C2777230088 @default.
• W4224050235 hasConcept C2778891590 @default.
• W4224050235 hasConcept C2778999818 @default.
• W4224050235 hasConcept C42360764 @default.
• W4224050235 hasConcept C42820424 @default.
• W4224050235 hasConcept C519063684 @default.
• W4224050235 hasConcept C523993062 @default.
• W4224050235 hasConcept C543218039 @default.
• W4224050235 hasConcept C55493867 @default.
• W4224050235 hasConcept C673006 @default.
• W4224050235 hasConcept C71924100 @default.

• next