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- W4224059954 abstract "Herein, we report an on-DNA photoredox-mediated deaminative alkylation method for diversifying DNA-tagged acrylamide substrate with amine-derived radicals. The radicals can be conveniently generated from sterically hindered primary amines, and the deaminative alkylation can tolerate a broad array of radical precursors. Furthermore, the methodology is applicable to Boc-protected diamines, free amino acids, and aryl halides, which bear functional groups enabling additional rounds of diversification. The method is believed to offer a high potential for constructing DNA-encoded libraries, as was demonstrated by the production of a mock library in a 2 × 3 matrix format and confirmation of DNA stability by UPLC-MS and qPCR experiments." @default.
- W4224059954 created "2022-04-19" @default.
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- W4224059954 date "2022-04-01" @default.
- W4224059954 modified "2023-10-16" @default.
- W4224059954 title "Photoredox Deaminative Alkylation in DNA-Encoded Library Synthesis" @default.
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- W4224059954 doi "https://doi.org/10.1021/acs.orglett.2c00697" @default.
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