Matches in SemOpenAlex for { <https://semopenalex.org/work/W4224069203> ?p ?o ?g. }
- W4224069203 abstract "Human culture, biology, and health were shaped dramatically by the onset of agriculture ∼12,000 y B.P. This shift is hypothesized to have resulted in increased individual fitness and population growth as evidenced by archaeological and population genomic data alongside a decline in physiological health as inferred from skeletal remains. Here, we consider osteological and ancient DNA data from the same prehistoric individuals to study human stature variation as a proxy for health across a transition to agriculture. Specifically, we compared “predicted” genetic contributions to height from paleogenomic data and “achieved” adult osteological height estimated from long bone measurements for 167 individuals across Europe spanning the Upper Paleolithic to Iron Age (∼38,000 to 2,400 B.P.). We found that individuals from the Neolithic were shorter than expected (given their individual polygenic height scores) by an average of −3.82 cm relative to individuals from the Upper Paleolithic and Mesolithic (P = 0.040) and −2.21 cm shorter relative to post-Neolithic individuals (P = 0.068), with osteological vs. expected stature steadily increasing across the Copper (+1.95 cm relative to the Neolithic), Bronze (+2.70 cm), and Iron (+3.27 cm) Ages. These results were attenuated when we additionally accounted for genome-wide genetic ancestry variation: for example, with Neolithic individuals −2.82 cm shorter than expected on average relative to pre-Neolithic individuals (P = 0.120). We also incorporated observations of paleopathological indicators of nonspecific stress that can persist from childhood to adulthood in skeletal remains into our model. Overall, our work highlights the potential of integrating disparate datasets to explore proxies of health in prehistory." @default.
- W4224069203 created "2022-04-19" @default.
- W4224069203 creator A5006604802 @default.
- W4224069203 creator A5006627839 @default.
- W4224069203 creator A5007110278 @default.
- W4224069203 creator A5011819951 @default.
- W4224069203 creator A5016621556 @default.
- W4224069203 creator A5016788821 @default.
- W4224069203 creator A5020724836 @default.
- W4224069203 creator A5024225439 @default.
- W4224069203 creator A5029348264 @default.
- W4224069203 creator A5030118753 @default.
- W4224069203 creator A5030559109 @default.
- W4224069203 creator A5031537478 @default.
- W4224069203 creator A5033468334 @default.
- W4224069203 creator A5034106885 @default.
- W4224069203 creator A5034933188 @default.
- W4224069203 creator A5036827132 @default.
- W4224069203 creator A5038378647 @default.
- W4224069203 creator A5040866237 @default.
- W4224069203 creator A5043940506 @default.
- W4224069203 creator A5048800382 @default.
- W4224069203 creator A5049368387 @default.
- W4224069203 creator A5049946900 @default.
- W4224069203 creator A5050191479 @default.
- W4224069203 creator A5050555580 @default.
- W4224069203 creator A5057216266 @default.
- W4224069203 creator A5057772766 @default.
- W4224069203 creator A5058354667 @default.
- W4224069203 creator A5060769578 @default.
- W4224069203 creator A5062554970 @default.
- W4224069203 creator A5064331241 @default.
- W4224069203 creator A5065891126 @default.
- W4224069203 creator A5067396636 @default.
- W4224069203 creator A5071714749 @default.
- W4224069203 creator A5074193113 @default.
- W4224069203 creator A5075152085 @default.
- W4224069203 creator A5075852187 @default.
- W4224069203 creator A5081175849 @default.
- W4224069203 creator A5082338579 @default.
- W4224069203 creator A5083897592 @default.
- W4224069203 creator A5086697466 @default.
- W4224069203 creator A5091560389 @default.
- W4224069203 date "2022-04-06" @default.
- W4224069203 modified "2023-10-14" @default.
- W4224069203 title "An integrative skeletal and paleogenomic analysis of stature variation suggests relatively reduced health for early European farmers" @default.
- W4224069203 cites W1113106786 @default.
- W4224069203 cites W1486022014 @default.
- W4224069203 cites W1490213859 @default.
- W4224069203 cites W1760976735 @default.
- W4224069203 cites W182932705 @default.
- W4224069203 cites W1964332640 @default.
- W4224069203 cites W1976696587 @default.
- W4224069203 cites W1978615674 @default.
- W4224069203 cites W1982113409 @default.
- W4224069203 cites W1984265749 @default.
- W4224069203 cites W1988663703 @default.
- W4224069203 cites W1993435119 @default.
- W4224069203 cites W1997927740 @default.
- W4224069203 cites W2005296173 @default.
- W4224069203 cites W2006861746 @default.
- W4224069203 cites W2011693775 @default.
- W4224069203 cites W2012602188 @default.
- W4224069203 cites W2017489446 @default.
- W4224069203 cites W2019734673 @default.
- W4224069203 cites W2023612345 @default.
- W4224069203 cites W2028765251 @default.
- W4224069203 cites W2029650791 @default.
- W4224069203 cites W2037679873 @default.
- W4224069203 cites W2044935753 @default.
- W4224069203 cites W2048785795 @default.
- W4224069203 cites W2050876420 @default.
- W4224069203 cites W2050967443 @default.
- W4224069203 cites W2055143118 @default.
- W4224069203 cites W2055787045 @default.
- W4224069203 cites W2064792632 @default.
- W4224069203 cites W2068224815 @default.
- W4224069203 cites W2068524195 @default.
- W4224069203 cites W2069909149 @default.
- W4224069203 cites W2079707657 @default.
- W4224069203 cites W2086666095 @default.
- W4224069203 cites W2090819968 @default.
- W4224069203 cites W2092516228 @default.
- W4224069203 cites W2093478783 @default.
- W4224069203 cites W2096367854 @default.
- W4224069203 cites W2099294263 @default.
- W4224069203 cites W2103441770 @default.
- W4224069203 cites W2104549677 @default.
- W4224069203 cites W2106578986 @default.
- W4224069203 cites W2108169091 @default.
- W4224069203 cites W2108234281 @default.
- W4224069203 cites W2110827314 @default.
- W4224069203 cites W2112370047 @default.
- W4224069203 cites W2119180969 @default.
- W4224069203 cites W2120144310 @default.
- W4224069203 cites W2123548894 @default.
- W4224069203 cites W2124031503 @default.
- W4224069203 cites W2136068873 @default.
- W4224069203 cites W2138345444 @default.
- W4224069203 cites W2142046799 @default.