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- W4224079535 abstract "Mutations in PARK7, the gene encoding the DJ-1 protein, are associated with early onset of Parkinson's disease. The C106 residue of DJ-1 is highly susceptible to oxidation, and its oxidation status is essential for various in vivo neuroprotective roles. Since C106 is readily oxidized to sulfinic acid that is not reduced by dithiothreitol, no method to separate native DJ-1 protein from the oxidized one creates challenges in the in vitro study of the biological relevance of C106-oxidation state. Here, we report an efficient column chromatography method to purify native, C106-sulfinic, and mixed (combination of the priors) forms of DJ-1. This method will be useful for systematic in vitro studies of DJ-1 functions by providing specific native and C106-sulfinic DJ-1 proteins." @default.
- W4224079535 created "2022-04-19" @default.
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- W4224079535 date "2022-08-01" @default.
- W4224079535 modified "2023-10-14" @default.
- W4224079535 title "Separation of native and C106-oxidized DJ-1 proteins by using column chromatography" @default.
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- W4224079535 doi "https://doi.org/10.1016/j.pep.2022.106092" @default.
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