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- W4224081947 abstract "Abstract Background The aim of this study was to investigate the effects of different thoracic radiotherapy doses on OS and incidence of radiation pneumonia which may provide some basis for optimizing the comprehensive treatment scheme of these patients with advanced EGFR mutant lung adenocarcinoma. Methods Data from 111 patients who received thoracic radiotherapy were included in this retrospective study. Overall survival (OS) was the primary endpoints of the study. Results The mOS rates of the patients, who received radiotherapy dose scheme of less than 50 Gy, 50–60 Gy (including 50 Gy), and 60 Gy or more were 29.1 months, 34.4 months, and 51.0 months, respectively (log-rank P = 0.011). The patients with different levels of radiation pneumonia did not differ in the three different radiotherapy dose scheme groups (χ 2 = 1.331; P = 0.514). The multivariate analysis showed that the thoracic radiotherapy dose schemes were independently associated with the improved OS of patients (adjusted hazard ratio [HR], 0.606; 95% CI, 0.382 to 0.961; P = 0.033;). Conclusions For the patients with advanced EGFR -mutant lung adenocarcinoma, the radical thoracic radiotherapy dose scheme (≥ 60Gy) could significantly prolong the OS of patients without increasing the occurrence of grade 3 radiation pneumonia during the whole course management." @default.
- W4224081947 created "2022-04-19" @default.
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- W4224081947 date "2022-04-15" @default.
- W4224081947 modified "2023-10-16" @default.
- W4224081947 title "Effect of thoracic radiotherapy dose on the prognosis of advanced lung adenocarcinoma harboring EGFR mutations" @default.
- W4224081947 doi "https://doi.org/10.21203/rs.3.rs-1349595/v1" @default.
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